INT91396

From wiki-pain
Revision as of 14:09, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.97
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
lung 2
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 151 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 99.48 Very High Very High Very High
Potency 1 99.16 Very High Very High Very High
Arthritis 4 92.04 High High
Inflammation 3 91.32 High High
Pain 1 90.64 High High
antagonist 1 82.16 Quite High
qutenza 3 80.64 Quite High
COX-2 inhibitor 19 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 3 97.72 Very High Very High Very High
Fibrosarcoma 3 96.08 Very High Very High Very High
Arthritis 4 92.04 High High
INFLAMMATION 3 91.32 High High
Arthralgia 1 90.64 High High
Prostate Cancer 3 83.84 Quite High
Colon Cancer 5 80.64 Quite High
Increased Venous Pressure Under Development 2 75.00 Quite High
Disease 7 69.44 Quite High
Cancer 37 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of MMP-2 increased the amount of intact CGRP in arteries and enhanced vasorelaxation induced by anandamide, which stimulates CGRP release.
Positive_regulation (increased) of Negative_regulation (Inhibition) of MMP-2 associated with metalloproteinase and calcitonin gene-related peptide
1) Confidence 0.33 Published 2000 Journal Circ. Res. Section Abstract Doc Link 11029402 Disease Relevance 0.14 Pain Relevance 1.13
Expression and activity of above MMPs studied suggested SG as a potent MMP inhibitor, and inhibition of MMP-2 and MMP-9 was due to down-regulation of transcription factor, NF-?
Positive_regulation (due) of Negative_regulation (inhibition) of MMP-2 associated with metalloproteinase
2) Confidence 0.33 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.56 Pain Relevance 0.23
Pan et al. [56] showed that NS-398 treatment resulted in a suppression in MMP-2 promoter activity, MMP mRNA and active MMP-2 protein by the A549 lung cancer cell line.
Positive_regulation (resulted) of Negative_regulation (suppression) of MMP-2 promoter in lung associated with lung cancer and metalloproteinase
3) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.26 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox