INT91417

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 18.45
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
Anatomy Link Frequency
endothelial cells 3
chondrocytes 1
dorsal 1
macrophages 1
colon 1
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 449 100.00 Very High Very High Very High
Inflammation 443 99.98 Very High Very High Very High
cINOD 61 99.98 Very High Very High Very High
cytokine 369 99.92 Very High Very High Very High
Central grey 1 99.58 Very High Very High Very High
Inflammatory stimuli 10 99.24 Very High Very High Very High
dexamethasone 3 98.68 Very High Very High Very High
Thermal hyperalgesia 1 97.78 Very High Very High Very High
Arthritis 20 97.40 Very High Very High Very High
cva 3 96.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 192 100.00 Very High Very High Very High
INFLAMMATION 516 99.98 Very High Very High Very High
Infection 448 99.98 Very High Very High Very High
Nociception 2 99.80 Very High Very High Very High
Herpes Simplex Virus 952 99.78 Very High Very High Very High
Urological Neuroanatomy 2 99.58 Very High Very High Very High
Bacterial Infection 7 98.48 Very High Very High Very High
Hyperalgesia 15 97.78 Very High Very High Very High
Arthritis 25 97.40 Very High Very High Very High
Sarcoma 316 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of mPGES-1 associated with inflammation
1) Confidence 0.68 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.49 Pain Relevance 0.34
PGH2, which is synthesized by the action of COX-2, is isomerized to PGE2 by terminal prostaglandin E synthase (PGES), and multiple isoforms of terminal PGES have so far been identified.12,16 The cytosolic PGES (cPGES) is constitutively expressed and functionally coupled to COX-1,17 whereas the microsomal prostaglandin E synthase-1 (mPGES-1) is rapidly induced by various stimuli in a COX-2 expression-related manner.12,16 The physiologic relevance of mPGES-1 expression in vivo has been substantiated recently by the finding that mPGES-1-deficient mice display attenuated responses to inflammation and pain.19 Furthermore, mPGES-1 is constitutively expressed in colon, lung, and gastric cancers,20-22 suggesting that it participates in tumorigenesis.
Positive_regulation (induced) of prostaglandin E synthase in lung associated with pain, inflammation and stomach cancer
2) Confidence 0.67 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.48 Pain Relevance 0.14
Microsomal prostaglandin E synthase-1 (MPGES1) is induced during an inflammatory reaction from low basal levels by pro-inflammatory cytokines and subsequently involved in the production of the important mediator of inflammation, prostaglandin E(2).
Positive_regulation (induced) of MPGES1 associated with inflammation and cytokine
3) Confidence 0.67 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20605783 Disease Relevance 0.37 Pain Relevance 0.35
Induction of mPGES-1 and its modulation by cytokines were confirmed at the protein level and correlated with PGE(2) production.
Positive_regulation (Induction) of mPGES-1 associated with cytokine
4) Confidence 0.66 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.42 Pain Relevance 0.36
Emerging evidence has disclosed that the transcriptional induction of mPGES-1 is primarily controlled by Egr-1 through two Egr-1 binding motifs identified in the proximal promoter region of mPGES-1 [36,37].
Positive_regulation (induction) of mPGES-1 in proximal
5) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.21 Pain Relevance 0.18
Induction of mPGES-1 protein and mRNA expression by single or repeated HNE treatments
Positive_regulation (Induction) of mPGES-1 protein
6) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.17 Pain Relevance 0.04
The transcription factor Egr-1 is believed to mediate the induction of a host of target genes such as mPGES-1, as suggested by Cheng and colleagues [8].
Positive_regulation (induction) of mPGES-1
7) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0
Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of microsomal prostaglandin E synthase-1 associated with inflammation
8) Confidence 0.59 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.49 Pain Relevance 0.34
Microsomal prostaglandin E synthase-1 (MPGES1) is induced during an inflammatory reaction from low basal levels by pro-inflammatory cytokines and subsequently involved in the production of the important mediator of inflammation, prostaglandin E(2).
Positive_regulation (induced) of Microsomal prostaglandin E synthase-1 associated with inflammation and cytokine
9) Confidence 0.58 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20605783 Disease Relevance 0.37 Pain Relevance 0.35
This profile of mPGES-1 inhibition, distinct from COX-2 inhibition in cells, validates mPGES-1 as an attractive target for therapeutic intervention.
Positive_regulation (validates) of mPGES-1
10) Confidence 0.49 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.29 Pain Relevance 0.19
B, C/EBP, AP-1, and Egr-1 transcription factors are involved in PGE2 synthesis catalyzed by induction of either COX-2 or mPGES-1.
Positive_regulation (induction) of mPGES-1
11) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.28 Pain Relevance 0.17
mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators".
Positive_regulation (mediators) of mPGES-1 associated with cancer
12) Confidence 0.48 Published 2010 Journal Biochimie Section Title Doc Link 20159031 Disease Relevance 0.73 Pain Relevance 0.21
Nuclear factor-kappa B regulates inducible prostaglandin E synthase expression in human amnion mesenchymal cells.
Positive_regulation (inducible) of prostaglandin E synthase in amnion associated with cytokine
13) Confidence 0.47 Published 2008 Journal Biol. Reprod. Section Title Doc Link 17928629 Disease Relevance 0.19 Pain Relevance 0.31
In endometriosis patients, sPLA(2)-IIA, mPGES-1 and 15-PGDH mRNA was significantly enhanced in peritoneal lesions compared with matched eutopic endometrium (P < 0.001, P < 0.001 and P = 0.005, respectively).
Positive_regulation (enhanced) of mPGES-1 in endometrium
14) Confidence 0.45 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20023295 Disease Relevance 0.07 Pain Relevance 0
In contrast to these conventional drugs, a new generation of NSAIDs targets the terminal enzyme MPGES1.
Positive_regulation (targets) of MPGES1 associated with cinod
15) Confidence 0.39 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20605783 Disease Relevance 0.36 Pain Relevance 0.37
PTGES induction was blocked both in the presence of pharmacological NFkappaB inhibitors and following adenovirus-mediated overexpression of a dominant-negative NFkappaB pathway protein.
Positive_regulation (induction) of PTGES
16) Confidence 0.38 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.13 Pain Relevance 0.22
In particular, the transcript encoding the inducible microsomal prostaglandin E synthase PTGES that catalyzes the conversion of prostaglandin PGH2 to PGE2 in the COX-2 sub-pathway, and thought to play a pathogenic role in a number of inflammatory processes [88] is significantly increased and has the highest statistical association with the disease phenotype (62% of gene variance explained by the disease phenotype according to multi-way ANOVA).
Positive_regulation (inducible) of microsomal prostaglandin E synthase associated with inflammation and disease
17) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 0.93 Pain Relevance 0.23
De novo KSHV infection induces COX-2 and m-PGES-1 in endothelial cells
Positive_regulation (induces) of m-PGES-1 in endothelial cells associated with herpes simplex virus and infection
18) Confidence 0.26 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.34 Pain Relevance 0
In addition, we also observed the concomitant induction of m-PGES-1, an enzyme converting PGH2 to PGE2, with about 13, 12.5, 11.3, 13, 10,11, 9, and 7-fold induction at 2 h, 4 h, 8 h, 1d, 2d, 3d, 4d and 5d PI, respectively (Figure 1D).
Positive_regulation (induction) of m-PGES-1
19) Confidence 0.26 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.27 Pain Relevance 0
The observed induction of PGES protein correlated with microsomal PGES activity.
Positive_regulation (induction) of PGES
20) Confidence 0.24 Published 2000 Journal Eur. J. Biochem. Section Abstract Doc Link 11029586 Disease Relevance 0.23 Pain Relevance 0.14

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