INT91432

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 9.79
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
ECM 6
chondrocyte 3
neural 2
spine 1
TMJ 1
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 77 99.56 Very High Very High Very High
Snapping jaw 7 99.48 Very High Very High Very High
Central nervous system 29 98.80 Very High Very High Very High
Osteoarthritis 141 97.78 Very High Very High Very High
metalloproteinase 112 96.12 Very High Very High Very High
cva 15 92.64 High High
Peripheral nervous system 3 90.96 High High
antagonist 9 89.92 High High
cytokine 30 83.76 Quite High
cINOD 13 78.88 Quite High
Disease Link Frequency Relevance Heat
Adhesions 201 99.84 Very High Very High Very High
Rheumatoid Arthritis 77 99.56 Very High Very High Very High
Temporomandibular Joint Syndrome 7 99.48 Very High Very High Very High
Cancer 170 99.46 Very High Very High Very High
Apoptosis 98 99.44 Very High Very High Very High
Death 38 98.48 Very High Very High Very High
Arthritis 5 98.12 Very High Very High Very High
Pancreatic Cancer 142 98.00 Very High Very High Very High
Knee Osteoarthritis 72 97.78 Very High Very High Very High
Infection 20 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In combination with other ECM proteins found in our analysis, PAI-1 and uPA, the association with DFI and OS became even more significant (p < 0.001).
ECM Binding (combination) of
1) Confidence 0.36 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499618 Disease Relevance 0.52 Pain Relevance 0.06
Overall, these results suggest that CD44H mediates the binding of some ECM proteins in TMJ disc cells.
ECM Binding (binding) of in TMJ associated with snapping jaw
2) Confidence 0.15 Published 2000 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11030403 Disease Relevance 0.85 Pain Relevance 0.54
Heparan sulfate proteoglycan 2 (perlecan) is an ECM protein closely associated with vascular endothelia, and has been shown to play a key role in vasculogenesis.
ECM protein Binding (associated) of in vascular endothelia
3) Confidence 0.11 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.41 Pain Relevance 0.04
This is due to the reduction in movement of the electrodes; from the interaction between the ECM of the neural tissue and that of the implant (Moxon et al., 2004).
ECM Binding (interaction) of in neural
4) Confidence 0.09 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2972680 Disease Relevance 0.09 Pain Relevance 0
Integrin molecular structure, heterodimerization, and intra- and extracellular interactions with cytoplasmic regulatory proteins and ECM ligands provide tremendous potential for variation among cell types, well beyond that available through quantitative variation in integrin expression level alone [63].
ECM Binding (interactions) of
5) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.53 Pain Relevance 0.08
The final component to this story includes the protease-receptor complexes, which are also molecular organizers of cell-to-ECM interactions.
ECM Binding (interactions) of
6) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.60 Pain Relevance 0.03
Recently there has been much speculation about the reason for this genetic heterogeneity, and a number of hypotheses have been suggested; i.e., 1) some mutations disrupt specific interactions between matrilin-3, type IX collagen, and COMP in the cartilage ECM [Briggs and Chapman, 2002]; 2) the blocked/delayed secretion of one mutant protein results in a cascade of protein retention within the rER of chondrocytes [Unger and Hecht, 2001]; or 3) a combination of both mechanisms [Dinser et al., 2002].
ECM Binding (interactions) of in chondrocytes
7) Confidence 0.06 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.38 Pain Relevance 0
After 4–5 days, when the cultures had reached confluence and the formation of an ECM had started, fresh medium was added containing 1 ?
ECM Binding (formation) of
8) Confidence 0.06 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.08 Pain Relevance 0
The ability of embryonic stem (ES) cells to generate neural cell types in vitro offers a powerful tool to study how the cell-ECM interactions regulate neural stem cell specification and lineage choice.
ECM Binding (interactions) of in neural
9) Confidence 0.04 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.06 Pain Relevance 0.16
The diversity of cell interactions with complex ECM components in the developing CNS challenges us to understand the role of cell-matrix interactions in neural differentiation of stem cells.
ECM Binding (interactions) of in stem cells associated with central nervous system
10) Confidence 0.04 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.07 Pain Relevance 0.18
Interactions of cells with the extracellular matrix (ECM) are critical for the establishment and maintenance of stem cell self-renewal and differentiation.
ECM Binding (Interactions) of in extracellular matrix
11) Confidence 0.04 Published 2008 Journal BMC Dev Biol Section Abstract Doc Link PMC2570688 Disease Relevance 0 Pain Relevance 0
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [4].
ECM Binding (interactions) of in chondrocyte
12) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 1.03 Pain Relevance 0.46
In OA, beta1 integrin expression is significantly reduced in damaged cartilage [5] and this would alter chondrocyte/ECM interactions and disrupt beta1 integrin/GFr synergy leading to activation of catabolic pathways, increase of MMPs expression and induction of chondrocyte apoptosis.
ECM Binding (interactions) of in chondrocyte associated with metalloproteinase, apoptosis and osteoarthritis
13) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.57 Pain Relevance 0.49
Targeted therapy against FAK by methods such as using specific phosphorylation inhibitors could potentially be used to inhibit the cell-ECM interaction and thus suppress CAM-DR.
ECM Binding (interaction) of
14) Confidence 0.04 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.33 Pain Relevance 0
Adrenomedullin increased RA-FLSs adhesion to the ECM proteins vitronectin, fibronectin, and Coll.I, which are abundant in the rheumatoid pannus.
ECM Binding (abundant) of associated with rheumatoid arthritis and adhesions
15) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.87 Pain Relevance 0.36
Chondrocyte phenotype and function are partially controlled by their interactions with the surrounding ECM.
ECM Binding (interactions) of in ECM
16) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.22 Pain Relevance 0.04
FAK is a key molecule in signal transduction from extracellular matrix (ECM) to cells, and it has been reported in recent years that the intrinsic chemoresistance of tumor cells could be induced by ECM-integrin interactions, named cell adhesion-mediated drug resistance (CAM-DR) [23].
ECM Binding (interactions) of in ECM associated with cancer and adhesions
17) Confidence 0.03 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.47 Pain Relevance 0
Collagen sponges supported the most abundant ECM formation, whether the ECM production was nearly absent in fibrin gel.
ECM Binding (formation) of
18) Confidence 0.02 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0 Pain Relevance 0
TGFBIp interacts with several extracellular matrix (ECM) proteins, including fibronectin, biglycan, decorin, and several types of collagen [32].
ECM Binding (interacts) of in extracellular matrix
19) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927433 Disease Relevance 0.06 Pain Relevance 0
Moreover, it retains its mitogenic capacity in spine tissues while decreasing ECM formation, leading to clustering of cells often seen in arthritic states.
ECM Binding (formation) of in spine associated with arthritis
20) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453768 Disease Relevance 0.10 Pain Relevance 0.04

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