INT91467

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COX5A) small molecule metabolic process (COX5A)
COX5A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 98.52 Very High Very High Very High
Inflammation 8 90.64 High High
Pain 1 89.28 High High
COX-2 inhibitor 3 75.00 Quite High
Potency 1 39.12 Quite Low
COX2 2 25.00 Low Low
cytokine 1 25.00 Low Low
tolerance 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 98.32 Very High Very High Very High
Toxicity 3 93.08 High High
Pain 1 89.28 High High
Injury 1 84.16 Quite High
Cancer 6 75.00 Quite High
Apoptosis 2 61.12 Quite High
Pancreatic Cancer 3 25.00 Low Low
Metastasis 1 25.00 Low Low
Solid Tumor 1 25.00 Low Low
Malignant Neoplastic Disease 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of prostaglandin biosynthesis via inhibition of the fatty acid cyclooxygenase (COX) is the mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs).
Negative_regulation (Inhibition) of Negative_regulation (inhibition) of COX associated with inflammation and cinod
1) Confidence 0.41 Published 2000 Journal Curr. Med. Chem. Section Abstract Doc Link 11032962 Disease Relevance 0.44 Pain Relevance 0.40
For more than a century, inhibition of prostaglandin biosynthesis via inhibition of the fatty acid cyclooxygenase (COX) has been achieved by non-steroidal anti-inflammatory drugs (NSAIDs), which targets both COX-1 and COX-2 and as such could be responsible for causing gastrointestinal (GI) toxicity.
Negative_regulation (inhibition) of Negative_regulation (inhibition) of COX associated with toxicity, inflammation and cinod
2) Confidence 0.41 Published 2007 Journal Mini Rev Med Chem Section Abstract Doc Link 17584158 Disease Relevance 0.45 Pain Relevance 0.23

General Comments

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