INT91544

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 60
Total Number 70
Disease Relevance 77.72
Pain Relevance 13.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
plasma 9
adipose tissue 8
macrophages 6
cartilage 4
smooth muscle 2
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 32 100.00 Very High Very High Very High
rheumatoid arthritis 573 99.98 Very High Very High Very High
Arthritis 244 99.56 Very High Very High Very High
Inflammation 825 99.24 Very High Very High Very High
tolerance 280 98.20 Very High Very High Very High
Chronic pancreatitis 24 97.96 Very High Very High Very High
spinal inflammation 48 96.84 Very High Very High Very High
Osteoarthritis 88 95.88 Very High Very High Very High
Pain 26 94.76 High High
Taxol 1 94.08 High High
Disease Link Frequency Relevance Heat
Obesity 1689 100.00 Very High Very High Very High
Calcification 930 100.00 Very High Very High Very High
INFLAMMATION 888 100.00 Very High Very High Very High
Insulin Resistance 145 100.00 Very High Very High Very High
Pancreatic Cancer 20 100.00 Very High Very High Very High
Rheumatoid Arthritis 652 99.98 Very High Very High Very High
Diabetes Mellitus 1399 99.76 Very High Very High Very High
Coronary Artery Disease 760 99.58 Very High Very High Very High
Arthritis 166 99.56 Very High Very High Very High
Cancer 195 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Soluble Fas ligand (CD178) inhibited synovial VEGF production and angiogenesis [16].
Gene_expression (production) of synovial
1) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.91 Pain Relevance 0.41
YKL-40 (chitinase-3-like-1 [CHI3L1], human cartilage glycoprotein-39), is a heparin-, chitin-, and collagen-binding lectin produced by immunologically active cells such as macrophages (1) and neutrophils (2).
Gene_expression (produced) of YKL-40 in neutrophils
2) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.15 Pain Relevance 0
In the present study, using plasma and adipose tissue biopsy material from 103 healthy control subjects and 96 patients with type 2 diabetes with a wide range of BMI, we studied the possible relationship between plasma YKL-40 and adipose tissue expression of YKL-40 on the one hand and obesity, insulin resistance, and inflammation on the other.
Gene_expression (expression) of YKL-40 in adipose tissue associated with inflammation, diabetes mellitus, obesity and insulin resistance
3) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.26 Pain Relevance 0.34
It cannot be excluded that adipose tissue is a source of YKL-40 production, though the production of YKL-40 may be attributed to different cells.
Gene_expression (production) of YKL-40 in adipose tissue associated with obesity
4) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.12 Pain Relevance 0.03
Given that YKL-40 is produced by macrophages, it is surprising that CD68 mRNA expression in adipose tissue did not correlate with plasma YKL-40.
Gene_expression (produced) of YKL-40 in plasma associated with obesity
5) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.11 Pain Relevance 0.05
Studying adipose tissue biopsies, we were not able to distinguish between the roles of macrophages and, for example, endothelial cells or smooth muscle cells with regard to the production of YKL-40.
Gene_expression (production) of YKL-40 in macrophages associated with obesity
6) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.04 Pain Relevance 0.03
The mean level of synovial CXCL10 in the autoimmune arthritis patients was comparable with that measured in septic arthritis [11].
Gene_expression (level) of synovial associated with infectious arthritis and arthritis
7) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.64 Pain Relevance 0.97
A recent report by Persiani et al. [29] showed that synovial GlcN concentration varied between 3 and 18 ?
Gene_expression (concentration) of synovial
8) Confidence 0.65 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0 Pain Relevance 0
We could confirm our hypothesis that the level of synovial TNF?
Gene_expression (level) of synovial
9) Confidence 0.65 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.43 Pain Relevance 0.21
In contrast, the synovial sRAGE levels in RA patients with erosive disease correlated significantly with synovial white blood cell counts (rs = 0.53, P < 0.04), whereas no association was found between synovial fluid sRAGE and synovial IL-6 levels in RA patients.


Gene_expression (levels) of synovial in white blood cell associated with rheumatoid arthritis and disease
10) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.18 Pain Relevance 0.50
In contrast to CXCL10, synovial CXCL8 concentrations were only significantly (P < 0.05) enhanced in RA patients, and not in PsA or AS patients, in comparison with CA patients (Figure 11).
Gene_expression (concentrations) of synovial associated with spinal inflammation, rheumatoid arthritis and arthritis
11) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 1.67 Pain Relevance 1.03
In this study we provide, to our knowledge, the first demonstration that AID is invariably expressed within rheumatoid synovial T/B cell aggregates containing CD21+ FDC networks, with a distribution closely recapitulating that seen in secondary lymphoid organs, providing direct evidence that ectopic GC-like structures represent a functional tertiary lymphoid organ capable of activating the molecular machinery necessary to sustain SHM and CSR within the synovial membrane.
Gene_expression (aggregates) of synovial in B cell
12) Confidence 0.65 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.41 Pain Relevance 0.17
These data support the DAMAGE study, which showed that synovial tissue IL-17 mRNA levels strongly correlate with CRP, and in synergy with TNF?
Gene_expression (levels) of synovial
13) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.87 Pain Relevance 0.38
Enrichment of total immunoglobulin in rheumatoid arthritis synovial tissue
Gene_expression (tissue) of synovial associated with rheumatoid arthritis
14) Confidence 0.65 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 1.79 Pain Relevance 0.80
It cannot be excluded that adipose tissue is a source of YKL-40 production, though the production of YKL-40 may be attributed to different cells.
Gene_expression (production) of YKL-40 in adipose tissue associated with obesity
15) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.07 Pain Relevance 0.03
Furthermore, visceral adipose tissue is more inflamed than subcutaneous adipose tissue and is a possible source of plasma YKL-40, but our study design did not allow for the illumination of the role of visceral fat.
Spec (possible) Gene_expression (source) of plasma YKL-40 in plasma associated with obesity
16) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.15 Pain Relevance 0.06
However, YKL-40 may only be produced by a subgroup of macrophages (CD14+ and CD16+) in adipose tissue, as seen in other diseases (1), in contrast with CD68, which is produced by all monocytes and macrophages.
Gene_expression (produced) of YKL-40 in macrophages associated with obesity and disease
17) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.22 Pain Relevance 0.04
In the present study, using plasma and adipose tissue biopsy material from 103 healthy control subjects and 96 patients with type 2 diabetes with a wide range of BMI, we studied the possible relationship between plasma YKL-40 and adipose tissue expression of YKL-40 on the one hand and obesity, insulin resistance, and inflammation on the other.
Gene_expression (expression) of plasma YKL-40 in adipose tissue associated with inflammation, diabetes mellitus, obesity and insulin resistance
18) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 2.28 Pain Relevance 0.34
However, here we demonstrate that YKL-40 levels do not fluctuate with acute changes in plasma glucose or plasma insulin.
Gene_expression (levels) of YKL-40 in plasma
19) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.09 Pain Relevance 0.04
YKL-40 (chitinase-3-like-1 [CHI3L1], human cartilage glycoprotein-39), is a heparin-, chitin-, and collagen-binding lectin produced by immunologically active cells such as macrophages (1) and neutrophils (2).
Gene_expression (produced) of chitinase-3-like-1 in neutrophils
20) Confidence 0.58 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.15 Pain Relevance 0

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