INT91555

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Context Info
Confidence 0.40
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.63
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr18) plasma membrane (Gpr18) signal transducer activity (Gpr18)
Anatomy Link Frequency
microglia 4
neuronal 1
Gpr18 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 99.00 Very High Very High Very High
antagonist 49 96.16 Very High Very High Very High
Nicotine 15 95.52 Very High Very High Very High
agonist 71 90.32 High High
Potency 25 90.32 High High
Cannabinoid 45 84.64 Quite High
Calcium channel 1 75.00 Quite High
IPN 6 70.88 Quite High
Analgesic 1 68.72 Quite High
Inflammatory response 6 67.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 61 99.00 Very High Very High Very High
Death 10 92.28 High High
Necrosis 2 89.88 High High
Cancer 2 89.52 High High
Inflammatory Pain 6 70.88 Quite High
Mycobacterial Infection 3 55.24 Quite High
Adhesions 1 41.52 Quite Low
Targeted Disruption 5 30.32 Quite Low
Bordatella Infection 10 24.92 Low Low
Neurodegenerative Disease 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, in subsequent experiments with HEK293 cells, which do not express CB2 receptors, we found that 100 nM SR144528 had no effect on HEK293 cells stably transfected with GPR18 induced in response to 1 ?
Positive_regulation (induced) of GPR18
1) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0.09 Pain Relevance 0
To further examine the hypothesis that NAGly is acting through GPR18 to mediate its migratory effects in BV-2 microglia, and in light of there being no known GPR18 antagonists, we modelled BV-2 microglial migratory observations using wildtype or HEK293 cells stably transfected with HA11-tagged GPR18 (HEK293-GPR18).
Positive_regulation (acting) of GPR18 in microglia associated with antagonist
2) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.05
Gpr18 was induced 52-fold in BMM following 6 h LPS exposure, while it remained unchanged in TEPM.
Positive_regulation (induced) of Gpr18
3) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.47 Pain Relevance 0.25
The NAGly-induced p44/42 MAPK activation observed with BV-2 microglia too was reproduced in HEK293-GPR18 cells (Figure 7E).
Positive_regulation (induced) of NAGly in microglia
4) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.16
Given the association between cell migration and proliferation, and that both are MAPK-dependent, 'Abn-CBD' receptor-activated phosphorylation of p44/42 and JNK MAPK in response to NAGly likely underlies the migratory and proliferative phenomena in BV-2 microglia.
Spec (likely) Positive_regulation (response) of NAGly in microglia
5) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0.07 Pain Relevance 0.05
To further examine the hypothesis that NAGly is acting through GPR18 to mediate its migratory effects in BV-2 microglia, and in light of there being no known GPR18 antagonists, we modelled BV-2 microglial migratory observations using wildtype or HEK293 cells stably transfected with HA11-tagged GPR18 (HEK293-GPR18).
Positive_regulation (acting) of NAGly in microglia associated with antagonist
6) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2865488 Disease Relevance 0 Pain Relevance 0.05
These results suggest that the nicotine-stimulated increase in DBI mRNA expression is mediated by CAM II kinase activation resulting from the increase in intracellular Ca(2+) through L-type VDCCs subsequent to the neuronal membrane depolarization associated with nACh receptor activation.
Positive_regulation (activation) of nACh receptor in neuronal associated with nicotine
7) Confidence 0.03 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.59

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