INT91659

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Context Info
Confidence 0.14
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.90
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
dendritic cells 6
plasma 2
macrophages 2
monocytes 2
lymphocytes 2
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 447 100.00 Very High Very High Very High
aspirin 12 91.96 High High
cINOD 10 87.88 High High
Inflammation 440 81.72 Quite High
chemokine 94 79.56 Quite High
Pain 1 68.48 Quite High
Inflammatory response 30 57.40 Quite High
bradykinin 1 23.84 Low Low
antagonist 136 5.00 Very Low Very Low Very Low
agonist 82 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 22 95.92 Very High Very High Very High
Organ Transplantation 4 94.08 High High
Apoptosis 38 87.92 High High
INFLAMMATION 477 86.28 High High
Asthma 1263 84.28 Quite High
Occupational Lung Diseases 60 76.24 Quite High
Leishmaniasis 33 73.80 Quite High
Weight Loss 1 65.72 Quite High
Anaemia 5 65.08 Quite High
Sepsis 62 63.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Negative_regulation (inhibition) of Localization (release) of IL-12 in monocytes
1) Confidence 0.14 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38
Insignificant decrease of plasma IL-12 and IL-10, negligible increase of Th1-cytokines, and persistence of IL-10, despite decrease in TGF-?
Negative_regulation (decrease) of Localization (decrease) of IL-12 in plasma associated with cytokine
2) Confidence 0.10 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.61 Pain Relevance 0.16
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Negative_regulation (inhibit) of Localization (secretion) of IL-12 in dendritic cells
3) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.68 Pain Relevance 0.24
expression occurred after inhibition of p38 MAPK in the presence of IL-12, indicating that the p38 MAPK pathway is involved in mediating IL-12-induced IFN-?
Negative_regulation (inhibition) of Localization (presence) of IL-12
4) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.03
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Negative_regulation (decrease) of Localization (secretion) of IL-12 in dendritic cells
5) Confidence 0.06 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.63 Pain Relevance 0.24
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Negative_regulation (inhibit) of in macrophages Localization (secretion) of IL-12 in dendritic cells
6) Confidence 0.03 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.68 Pain Relevance 0.24
Glucocorticoids, in vitro (a) inhibit IL-12 secretion from monocyte-macrophages and dendritic cells, (b) decrease IL-12 receptor 1- and 2-chain expression, thereby inhibiting IL-12 signaling, and (c) inhibit IL-12-induced STAT-4 (transcription factor that drives Th1 differentiation) phosphorylation without affecting STAT-6 (transcription factor that drives Th2 differentiation) phosphorylation (d), and thereby deviate the immune response predominantly toward the Th2 phenotype [8,12].
Negative_regulation (decrease) of in macrophages Localization (secretion) of IL-12 in dendritic cells
7) Confidence 0.02 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.63 Pain Relevance 0.24
Inhibition of IL-12 secretion and of the expression of its receptors on T and natural killer lymphocytes favours IL-4 production and lifts the suppressive effects of IL-12 on Th2 activity.
Negative_regulation (Inhibition) of Localization (secretion) of IL-12 in lymphocytes
8) Confidence 0.01 Published 2004 Journal Crit Care Section Body Doc Link PMC420022 Disease Relevance 0.42 Pain Relevance 0.21

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