INT91764

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.43
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLA2G4A) aging (PLA2G4A) Golgi apparatus (PLA2G4A)
endoplasmic reticulum (PLA2G4A) cytoplasmic membrane-bounded vesicle (PLA2G4A) nucleus (PLA2G4A)
Anatomy Link Frequency
fibroblasts 6
brain 2
PLA2G4A (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 99.32 Very High Very High Very High
COX2 3 98.04 Very High Very High Very High
cINOD 25 97.08 Very High Very High Very High
Inflammation 136 96.72 Very High Very High Very High
fibrosis 14 92.00 High High
chemokine 15 83.80 Quite High
cytokine 41 83.20 Quite High
antagonist 5 82.40 Quite High
Pain 1 79.64 Quite High
Inflammatory response 12 76.32 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 6 99.78 Very High Very High Very High
Cv General 4 Under Development 1 99.68 Very High Very High Very High
Injury 2 98.80 Very High Very High Very High
Epilepsy 1 98.48 Very High Very High Very High
Disease 59 97.96 Very High Very High Very High
INFLAMMATION 150 96.84 Very High Very High Very High
Cancer 25 94.96 High High
Brain Injury 1 94.80 High High
Sepsis 2 94.16 High High
Lung Injury 2 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was designed to examine the molecular mechanisms underlying glucocorticoid-induced PLA2G4A expression in human amnion fibroblasts.
Positive_regulation (induced) of Gene_expression (expression) of PLA2G4A in fibroblasts
1) Confidence 0.69 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.20 Pain Relevance 0.16
Paradoxically, GCs are reported to stimulate cytosolic phosphoplipase A2 group IVA (PLA2G4A) and prostaglandin-endoperoxide synthase 2 (PTGS2) expression in human amnion fibroblasts.
Positive_regulation (stimulate) of Gene_expression (expression) of PLA2G4A in fibroblasts
2) Confidence 0.50 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.10 Pain Relevance 0.16
Paradoxically, GCs are reported to stimulate cytosolic phosphoplipase A2 group IVA (PLA2G4A) and prostaglandin-endoperoxide synthase 2 (PTGS2) expression in human amnion fibroblasts.
Positive_regulation (stimulate) of Gene_expression (expression) of phosphoplipase A2 group IVA in fibroblasts
3) Confidence 0.50 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.10 Pain Relevance 0.16
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Positive_regulation (increase) of Gene_expression (expression) of cPLA2alpha
4) Confidence 0.49 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.58 Pain Relevance 0.21
Expression of the inducible oxidoreductase cyclooxygenase-2 and cytosolic phospholipase A2 (cPLA2) are strongly activated during cerebral ischemia and trauma, epilepsy and AD, indicating the induction of proinflammatory gene pathways as a response to brain injury.
Positive_regulation (activated) of Gene_expression (Expression) of cPLA2 in brain associated with epilepsy, cv general 4 under development, ischemia, injury, disease and brain injury
5) Confidence 0.34 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.43 Pain Relevance 0.26
It has been shown that cPLA2 overexpression significantly increased the PPAR-?
Positive_regulation (increased) of Gene_expression (overexpression) of cPLA2
6) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 1.14 Pain Relevance 0.12
It has been shown that cPLA2 overexpression significantly increased the PPAR-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of cPLA2
7) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 1.12 Pain Relevance 0.12
An analysis of eight colorectal cancer cell lines and 65 colorectal cancers showed an overexpression of cPLA2 in about 50% of the cases which correlated with COX2 expression in a positive manner [72].
Positive_regulation (overexpression) of Gene_expression (overexpression) of cPLA2 associated with colon cancer and cox2
8) Confidence 0.20 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.76 Pain Relevance 0.32

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