INT91773

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.40
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLA2G4A) aging (PLA2G4A) Golgi apparatus (PLA2G4A)
endoplasmic reticulum (PLA2G4A) cytoplasmic membrane-bounded vesicle (PLA2G4A) nucleus (PLA2G4A)
Anatomy Link Frequency
fibroblasts 2
brain 1
PLA2G4A (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 99.32 Very High Very High Very High
Inflammation 163 98.32 Very High Very High Very High
COX2 5 96.56 Very High Very High Very High
antagonist 8 95.68 Very High Very High Very High
Analgesic 6 91.12 High High
cytokine 20 90.04 High High
agonist 12 88.48 High High
Inflammatory mediators 7 84.64 Quite High
cINOD 25 83.08 Quite High
chemokine 1 80.12 Quite High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 1 99.68 Very High Very High Very High
Stress 11 99.04 Very High Very High Very High
Injury 24 98.80 Very High Very High Very High
Epilepsy 1 98.48 Very High Very High Very High
INFLAMMATION 181 98.32 Very High Very High Very High
Disease 61 97.96 Very High Very High Very High
Brain Injury 1 94.80 High High
Colon Cancer 21 93.08 High High
Pressure Volume 2 Under Development 2 92.32 High High
Cancer 20 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we demonstrated in this study that cortisol increased PLA2G4A mRNA level via GR-dependent ongoing transcription in human amnion fibroblasts by activating the binding of GR to PLA2G4A promoter directly, and this effect appeared unlikely to be secondary to the effect of cortisol on the expression of proinflammatory cytokines in human amnion fibroblasts.
Positive_regulation (increased) of PLA2G4A mRNA in fibroblasts associated with cytokine
1) Confidence 0.50 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.14 Pain Relevance 0.11
Expression of the inducible oxidoreductase cyclooxygenase-2 and cytosolic phospholipase A2 (cPLA2) are strongly activated during cerebral ischemia and trauma, epilepsy and AD, indicating the induction of proinflammatory gene pathways as a response to brain injury.
Positive_regulation (activated) of cPLA2 in brain associated with epilepsy, cv general 4 under development, ischemia, injury, disease and brain injury
2) Confidence 0.47 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.40 Pain Relevance 0.25
Our data showed that cortisol (0.01 approximately 1 microM) increased PLA2G4A mRNA level in a dose-dependent manner in human amnion fibroblasts, which was blocked by glucocorticoid receptor antagonist RU486 (1 microM) as well as by the mRNA transcription inhibitor 5,6-dichlorobenzimidazole riboside (DRB; 75 microM).
Positive_regulation (increased) of PLA2G4A mRNA in fibroblasts associated with antagonist
3) Confidence 0.46 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.21 Pain Relevance 0.17
Fluocinolone acetonide (D01825) (Emerit et al., 1983) and fluocinonide (D00325) (Schlessinger et al., 2006) are known to act on human cytosolic calcium-dependent phospholipase A2 (PLA2G4A), which is involved in lipid metabolism and related to various signal transductions (Balsinde et al., 1999).
Positive_regulation (dependent) of PLA2G4A
4) Confidence 0.45 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2881361 Disease Relevance 0 Pain Relevance 0.34
Thus, cPLA2 is not required for translocation of cytosolic factors to membranes [139, 140].
Neg (not) Positive_regulation (required) of cPLA2
5) Confidence 0.27 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.03
is required for cPLA2 activity [145], supporting evidence that Ca2+ regulates NADPH oxidase through the PKC/cPLA2/arachidonic acid pathway.
Positive_regulation (required) of cPLA2
6) Confidence 0.27 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Several PLA2 isoforms have been described including a cPLA2, which is activated rapidly by increased [Ca2+]c.
Positive_regulation (activated) of cPLA2
7) Confidence 0.27 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.04
Ultraviolet radiation (both UVA and UVB) is known to increase levels of oxidative stress within cells (Malorni et al., 1996), which can activate cytoplasmic phospholipase A2 (cPLA2) (Chen et al., 1996).
Positive_regulation (activate) of cPLA2 associated with stress
8) Confidence 0.20 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.62 Pain Relevance 0.11
Taken together, experimental findings show the involvement of cPLA2?
Positive_regulation (involvement) of cPLA2
9) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.87 Pain Relevance 0.38
In human, an adult male with inherited cPLA2?
Positive_regulation (inherited) of cPLA2
10) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.66 Pain Relevance 0.12
Classically, activation of cytosolic phospholipase A2 has been considered as the rate-limiting step in the generation of AA.
Positive_regulation (activation) of cytosolic phospholipase A2
11) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.50 Pain Relevance 0

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