INT91836

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.59
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L1) mitochondrion (BCL2L1) growth (BCL2L1)
cytoskeleton (BCL2L1) nucleus (BCL2L1) intracellular (BCL2L1)
Anatomy Link Frequency
B cells 2
colon 2
heart 2
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 15 99.98 Very High Very High Very High
Paracetamol 12 98.28 Very High Very High Very High
ischemia 3 65.44 Quite High
Pain 2 62.04 Quite High
qutenza 3 50.00 Quite Low
Analgesic 1 47.76 Quite Low
cytokine 5 19.92 Low Low
addiction 1 16.48 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 2 100.00 Very High Very High Very High
Apoptosis 136 99.90 Very High Very High Very High
Colon Cancer 21 99.68 Very High Very High Very High
INFLAMMATION 5 99.04 Very High Very High Very High
B-cell Lymphoma 3 98.72 Very High Very High Very High
Hypothermia 13 98.48 Very High Very High Very High
Hodgkin's Disease 1 98.36 Very High Very High Very High
Death 26 97.92 Very High Very High Very High
Breast Cancer 7 93.92 High High
Cerebral Hypoxia 1 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs inhibited the expression of the antiapoptotic protein Bcl-XL, resulting in an altered ratio of BAX to Bcl-XL and subsequent mitochondria-mediated cell death.
Negative_regulation (inhibited) of Gene_expression (expression) of Bcl-XL associated with cinod and death
1) Confidence 0.49 Published 2000 Journal Science Section Abstract Doc Link 11062132 Disease Relevance 0.89 Pain Relevance 0.30
Our previous study demonstrated that NSAIDs require the proapoptotic B-cell non-Hodgkin lymphoma-2 (Bcl-2) family member Bcl-2-associated x protein (BAX) to induce apoptosis and inhibit the expression of antiapoptotic basal cell lymphoma-extra large (Bcl-X(L)) in colon cancer cells.
Negative_regulation (inhibit) of Gene_expression (expression) of Bcl-X in colon associated with lymphatic system cancer, colon cancer, cinod, hodgkin's disease and apoptosis
2) Confidence 0.42 Published 2008 Journal Nutr Cancer Section Abstract Doc Link 19003586 Disease Relevance 1.18 Pain Relevance 0.90
Overexpression of the antiapoptotic protein Bcl-XL prevented these various apoptotic events induced by acetaminophen in Jurkat cells.
Negative_regulation (prevented) of Gene_expression (Overexpression) of Bcl-XL associated with paracetamol and apoptosis
3) Confidence 0.33 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12005112 Disease Relevance 0.60 Pain Relevance 0.85
Chimeric anti-CD20 antibody (rituximab) sensitizes B cells in NHL to inducing apoptosis by cytotoxic substances, for example, by diminishing the Bcl-x expression [23].
Negative_regulation (diminishing) of Gene_expression (expression) of Bcl-x in B cells associated with b-cell lymphoma and apoptosis
4) Confidence 0.25 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.75 Pain Relevance 0.06
We additionally demonstrate that TRAIL/Apo2L-induced death of p53(+/+)- or p53(-/-)- BAX-proficient but not BAX-deficient colorectal cancer cells is augmented by reducing nuclear factor-kappaB-dependent expression of Bcl-x(L) with either a peptide that disrupts the inhibitor of kappaB kinase complex or the nonsteroidal anti-inflammatory drug, sulindac sulfide.
Negative_regulation (reducing) of Gene_expression (expression) of Bcl-x associated with inflammation, colon cancer, cinod and death
5) Confidence 0.20 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11912124 Disease Relevance 1.60 Pain Relevance 0.10
HSF1-silenced cells showed dramatically elevated levels of JNK1 phosphorylation, which is a trigger for apoptosis, as well as decreased levels of Bcl-xL, which is an inhibitor of apoptosis.
Negative_regulation (decreased) of Gene_expression (levels) of Bcl-xL associated with apoptosis
6) Confidence 0.11 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.76 Pain Relevance 0
Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.
Negative_regulation (down-regulated) of Gene_expression (expression) of Bcl-xL
7) Confidence 0.10 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.06 Pain Relevance 0
B with a subsequent reduction in Bcl-xL expression [79].
Negative_regulation (reduction) of Gene_expression (expression) of Bcl-xL
8) Confidence 0.08 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.62 Pain Relevance 0
Other authors, on the contrary, have assessed by gene array analysis a protective effect of hypothermia (30°C) on the cardioplegia-arrested rabbit heart, based on its ability for decreasing the expression of proapoptotic proteins (p53, bak) and promoting antiapoptotic factors (Bcl-x) [19].
Negative_regulation (decreasing) of Gene_expression (expression) of Bcl-x in heart associated with hypothermia
9) Confidence 0.08 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 1.12 Pain Relevance 0.03

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