INT91872

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.28
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RPA1) chromosome organization (RPA1) nucleolus (RPA1)
nucleus (RPA1) DNA binding (RPA1) cytoplasm (RPA1)
Anatomy Link Frequency
endothelial cells 2
liver 1
skin 1
kidney 1
placenta 1
RPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 87 92.76 High High
Arthritis 28 86.72 High High
Angina 6 82.04 Quite High
Inflammation 10 80.24 Quite High
alcohol 7 59.12 Quite High
Paracetamol 2 52.64 Quite High
Osteoarthritis 7 51.24 Quite High
backache 2 44.20 Quite Low
spastic colon 2 43.16 Quite Low
antagonist 7 14.00 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 87 92.76 High High
Autoimmune Hepatitis 20 92.72 High High
Gallstones 2 87.36 High High
Cognitive Disorder 1 87.24 High High
Arthritis 24 86.72 High High
Myocardial Infarction 3 83.08 Quite High
Hepatitis 37 82.12 Quite High
Cv General 3 Under Development 6 82.04 Quite High
Necrosis 9 81.84 Quite High
Spasticity 6 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human umbilical vein endothelial cells, inhibition of RPA1 expression using antisense oligonucleotide restored transcription driven by the mutated promoter sequence, whereas, conversely, overexpression of RPA1 further reduced it.
Gene_expression (expression) of RPA1 in endothelial cells
1) Confidence 0.77 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.40 Pain Relevance 0.16
In human umbilical vein endothelial cells, inhibition of RPA1 expression using antisense oligonucleotide restored transcription driven by the mutated promoter sequence, whereas, conversely, overexpression of RPA1 further reduced it.
Gene_expression (overexpression) of RPA1 in endothelial cells
2) Confidence 0.77 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.38 Pain Relevance 0.15
RPA1 was similarly detected in placenta and eNOS mRNA levels in placentas carrying the -786T-->C mutation were significantly lower than in placentas without it.
Gene_expression (detected) of RPA1 in placenta
3) Confidence 0.60 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.38 Pain Relevance 0.15
Our results suggest that human skin might respond to RF-EMF and change protein expression profile.
Gene_expression (expression) of RF-EMF in skin
4) Confidence 0.56 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2258283 Disease Relevance 0.16 Pain Relevance 0
In this study, a mid-range sensitivity and excellent diagnostic specificity were documented for the simultaneous detection of anti-MCV antibodies and RF-IgG using POCT.
Gene_expression (detection) of RF-IgG
5) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911914 Disease Relevance 0.45 Pain Relevance 0.17
Having defined the ELISA results as the gold standard these results led to an overall sensitivity of 69.3% for detection of anti MCV antibodies and of 55.6% for RF-IgG as well as to a specificity of 99.7% for MCV and of 97.2% for RF-IgG.
Gene_expression (detection) of RF-IgG
6) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911914 Disease Relevance 0.46 Pain Relevance 0.14
Similar phenotypes were reported when levels of MTSSB-1, mitochondrial single-stranded DNA binding protein, were highly reduced after RNAi using a continuous feeding over generations (27).
Gene_expression (levels) of single-stranded DNA binding protein
7) Confidence 0.03 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.41 Pain Relevance 0
Double stranded DNA antibodies, anti-mitochondrial antibodies and liver/kidney microsomal antibodies were not detected.
Neg (not) Gene_expression (detected) of stranded in kidney
8) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2955056 Disease Relevance 1.16 Pain Relevance 0.12
This limitation is that genes within single-stranded AAV genomes cannot be expressed unless the host cells successfully undertake second-strand synthesis.
Neg (cannot) Gene_expression (expressed) of single-stranded
9) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483436 Disease Relevance 0.32 Pain Relevance 0.10
Double stranded DNA antibodies, anti-mitochondrial antibodies and liver/kidney microsomal antibodies were not detected.
Neg (not) Gene_expression (detected) of stranded in liver
10) Confidence 0.00 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2955056 Disease Relevance 1.16 Pain Relevance 0.12

General Comments

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