INT9188

Context Info Confidence 0.75 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 12 Total Number 12 Disease Relevance 8.14 Pain Relevance 2.24

cytosol (HBG1) transport (HBG1)

Anatomy Link Frequency blood 1 erythrocytes 1 urine 1 14.2 1 HBG1 (Homo sapiens)

Pain Link Frequency Relevance Heat abdominal pain 7 99.54 Opioid 4 99.34 anesthesia 17 98.36 Inflammation 23 85.76 iatrogenic 1 84.72 lidocaine 4 81.64 cINOD 12 80.04 peptic ulcer disease 3 68.88 alcohol 2 57.76 ischemia 4 56.88

Disease Link Frequency Relevance Heat Hemolysis 7 99.78 Abdominal Pain 7 99.54 Ecchymosis 5 99.32 Anaemia 85 98.90 Vomiting 27 98.84 Heart Rate Under Development 6 98.12 Cancer 23 97.14 Acute Abdomen 5 96.68 Fever 4 96.68 Hematoma 29 95.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inspiratory mask pressure, arterial O2 saturation of hemoglobin, and end-tidal PCO2 during occlusions were similar before and after UA anesthesia.

Localization (saturation) of hemoglobin associated with anesthesia

1) Confidence 0.75 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1399992 Disease Relevance 0 Pain Relevance 1.07

In the calorimetric profiles observed during hemolysis by anionic drugs, two stages were seen: the first, an exothermic process, arising from drug binding to the erythrocytes; the second, an endothermic process, corresponding to the heat of dilution of hemoglobin released from erythrocytes.

Localization (released) of hemoglobin in erythrocytes associated with hemolysis

2) Confidence 0.63 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1986737 Disease Relevance 0.35 Pain Relevance 0.08

The hemorphins are peptides with opioid activity, which are enzymatically released from hemoglobin.

Localization (released) of hemoglobin associated with opioid

3) Confidence 0.63 Published 1992 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1575724 Disease Relevance 0 Pain Relevance 0.17

Common presenting signs and syptoms are abdominal pain, abdominal wall mass, decrease in hemoglobin, abdominal wall ecchymosis, nausea, vomiting, tachycardia, peritoneal irritation, fever, abdominal distention and abdominal cramping [7].

Localization (decrease) of hemoglobin associated with heart rate under development, ecchymosis, abdominal pain, vomiting and fever

4) Confidence 0.42 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2254639 Disease Relevance 1.66 Pain Relevance 0.27

Immediate preoperative as well as postoperative hemoglobin, hematocrite, serum sodium and potassium, blood urea, serum creatinine, random blood glucose, serum osmolarity, arterial blood gas, as well as serum troponin-I as a cardiac cell injury marker were measured.

Localization (preoperative) of hemoglobin in blood associated with injury

5) Confidence 0.30 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2891743 Disease Relevance 0.63 Pain Relevance 0.10

Release of hemorphin-5 from human hemoglobin by pancreatic elastase.

Localization (Release) of hemoglobin

6) Confidence 0.26 Published 2002 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 12092829 Disease Relevance 0 Pain Relevance 0.10

Opioid peptide hemorphin-5 (YPWTQ) was released from human hemoglobin by the action of pancreatic elastase.

Localization (released) of hemoglobin associated with opioid

7) Confidence 0.26 Published 2002 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 12092829 Disease Relevance 0 Pain Relevance 0.10

His hemoglobin had decreased from a value of 14.2 g/dL 8 months previously to a value of 11.4 g/dL on admission.

Localization (decreased) of hemoglobin in 14.2

8) Confidence 0.18 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC1852910 Disease Relevance 0.75 Pain Relevance 0.11

Hemoglobin decrease was 1,2 mg/ml and there existed no need for transfusion.

Localization (decrease) of Hemoglobin

9) Confidence 0.16 Published 2002 Journal BMC Urol Section Body Doc Link PMC130023 Disease Relevance 0.13 Pain Relevance 0

T) and thus are incomplete nonsecretors, producing small amounts of ABO and Leb HBGA in secretions.

Localization (secretions) of HBGA

10) Confidence 0.06 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874438 Disease Relevance 1.08 Pain Relevance 0

An exception can be tumors or lesions of the urothelium, which can bleed occultly prior to producing symptoms, or more rarely, chronic intravascular hemolysis, in which hemoglobin is released from damaged red cells into the plasma, where it is excreted in the urine, detectable as hemosiderin in the urine sediment.

Localization (released) of hemoglobin in urine associated with cancer and hemolysis

11) Confidence 0.03 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 1.91 Pain Relevance 0.12

Correcting anemia improves the quality of life in anemic patients, with normalization of hemoglobin and ferritin being the treatment goals.

Localization (normalization) of hemoglobin associated with anaemia

12) Confidence 0.01 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 1.63 Pain Relevance 0.11

General Comments

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