INT91891

Context Info Confidence 0.78 First Reported 2000 Last Reported 2010 Negated 10 Speculated 2 Reported most in Body Documents 268 Total Number 270 Disease Relevance 158.89 Pain Relevance 22.67

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit) plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)

Anatomy Link Frequency epidermis 14 mast cells 9 interstitial cells 7 liver 5 stem cell 5 Kit (Mus musculus) Kit - D816V (1) Kit - V654A (1)

Pain Link Frequency Relevance Heat rheumatoid arthritis 877 100.00 Calcitonin gene-related peptide 48 100.00 addiction 8 99.96 Spinal cord 135 99.88 COX2 2 99.64 Somatostatin 4 99.56 chemokine 155 99.36 substance P 101 99.28 qutenza 35 99.06 spastic colon 385 98.94

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 879 100.00 Sprains And Strains 267 100.00 Cancer 5331 99.98 Gastrointestinal Stromal Tumor 3749 99.98 Targeted Disruption 396 99.86 Muscle Tissue Neoplasms 6 99.82 Anaemia 208 99.80 Uterine Fibroids 103 99.54 Rhinitis 134 99.40 Renal Cancer 15 99.28

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Event

Anatomy

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Speculation

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Disease term

Kit expression was detected in a large number of cells in the liver from 0.5 to 2.5 dpp, as a reminiscence of fetal hematopoiesis (Figure 5A).

Gene_expression (expression) of Kit in liver associated with hematological disease

1) Confidence 0.78 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.30 Pain Relevance 0

Consistent with the phenotype, Kit gene expression was detected during post-natal development in the liver by using the lacZ reporter gene inserted in the first exon of Kit from the Kittm1Alf/+ mouse [8].

Gene_expression (expression) of Kit in liver

2) Confidence 0.78 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.31 Pain Relevance 0

Based on several features, including KIT expression and KIT dependence, ICC-like cells were identified in nongastrointestinal tissues.

Gene_expression (expression) of KIT associated with addiction

3) Confidence 0.78 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18480468 Disease Relevance 0.16 Pain Relevance 0.25

These tumors are identified by expression of CD117 or CD34 antigen.

Gene_expression (expression) of CD117

4) Confidence 0.77 Published 2008 Journal J Egypt Natl Canc Inst Section Abstract Doc Link 19847285 Disease Relevance 0.94 Pain Relevance 0.10

After stem cell kinase receptor CD117 (c-Kit) was introduced, the GISTs presumed to derive from stem cells differentiating to the GI pacemaker cells, known as interstitial cells of Cajal (ICC), because nearly all GISTs are implicated with c-Kit gene abnormality and CD117 (c-Kit) overexpression (1).

Gene_expression (overexpression) of Kit in interstitial cells

5) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.32 Pain Relevance 0.03

After stem cell kinase receptor CD117 (c-Kit) was introduced, the GISTs presumed to derive from stem cells differentiating to the GI pacemaker cells, known as interstitial cells of Cajal (ICC), because nearly all GISTs are implicated with c-Kit gene abnormality and CD117 (c-Kit) overexpression (1).

Gene_expression (overexpression) of CD117 in interstitial cells

6) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.32 Pain Relevance 0.03

The exceptions were very clearly described in the paper of Christopher et al.; including fixation artifact, technical error of immunostaining, sampling error, cessation of Kit expression perhaps following STI-571 therapy and very rare cases (2%) with real lack of Kit mutation and/or Kit expression (15).

Gene_expression (expression) of Kit

7) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.31 Pain Relevance 0

Tumors of our cases also showed variable histology, but immunohistochemically, our cases were compatible with GISTs or GANTs based on expression of vimentin (100%), CD117 (100%), and CD34 (66.7%).

Gene_expression (expression) of CD117 associated with cancer

8) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 0.91 Pain Relevance 0

g of total RNA were subsequently used to synthesize cDNA using the First Strand cDNA synthesis kit (Roche, Switzerland).

Gene_expression (synthesize) of kit

9) Confidence 0.75 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.88 Pain Relevance 0.14

The proliferation of the KIT-expressing and imatinib-sensitive and KIT-expressing but imatinib-resistant cell lines was inhibited by 17-AAG, but that of the KIT-non-expressing and imatinib-resistant cell line was not.

Gene_expression (expressing) of KIT

10) Confidence 0.75 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.57 Pain Relevance 0

The proliferation of the KIT-expressing and imatinib-sensitive and KIT-expressing but imatinib-resistant cell lines was inhibited by 17-AAG, but that of the KIT-non-expressing and imatinib-resistant cell line was not.

Gene_expression (expressing) of KIT

11) Confidence 0.75 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.56 Pain Relevance 0

Gastrointestinal stromal tumors of the small intestine that expressed c-kit protein.

Gene_expression (expressed) of c-kit protein in small intestine associated with gastrointestinal stromal tumor

12) Confidence 0.74 Published 2000 Journal Intern. Med. Section Title Doc Link 11065242 Disease Relevance 0.88 Pain Relevance 0.08

We report two patients with gastrointestinal stromal tumors (GISTs) of the small intestine that expressed c-kit protein (CD117).

Gene_expression (expressed) of c-kit protein in small intestine associated with gastrointestinal stromal tumor

13) Confidence 0.74 Published 2000 Journal Intern. Med. Section Abstract Doc Link 11065242 Disease Relevance 0.82 Pain Relevance 0.08

We report two patients with gastrointestinal stromal tumors (GISTs) of the small intestine that expressed c-kit protein (CD117).

Gene_expression (expressed) of CD117 in small intestine associated with gastrointestinal stromal tumor

14) Confidence 0.74 Published 2000 Journal Intern. Med. Section Abstract Doc Link 11065242 Disease Relevance 0.82 Pain Relevance 0.08

The immunohistochemical detection of the protein CD 117 (c-kit) is an important diagnostic tool.

Gene_expression (detection) of c-kit

15) Confidence 0.73 Published 2006 Journal Med. Klin. (Munich) Section Abstract Doc Link 16418817 Disease Relevance 1.35 Pain Relevance 0.11

point mutation and protein activation, superimposed on the original mutation in that gene. 2) KIT genomic amplification with overexpression of the KIT oncoprotein, without a new point mutation. 3) Target modulation – activation of an alternate receptor tyrosine kinase protein, accompanied by loss of KIT oncoprotein expression. 4) Functional resistance – KIT or PDGFR?

Gene_expression (overexpression) of KIT oncoprotein

16) Confidence 0.69 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.19 Pain Relevance 0

KIT overexpression is common in a variety of tumor types including GISTs, seminomas, adenoid cystic carcinomas, malignant melanomas, and lung carcinomas (non-small cell and small cell types) (Takahashi et al 1995; Went et al 2004).

Gene_expression (overexpression) of KIT in lung associated with seminoma, lung cancer, melanoma, cancer and adenoid cystic carcinoma

17) Confidence 0.69 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.98 Pain Relevance 0

The KIT proto-oncogene on chromosome 4 (4q11–q12) encodes for the KIT protein, which is also expressed on mast cells, germ cells, and hemopoietic cells.

Gene_expression (expressed) of KIT in hemopoietic cells

18) Confidence 0.69 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.61 Pain Relevance 0

Thereafter, Kit expression was confined to a few cells located in the hepatic parenchyma and was also found in the epithelial cells of the biliary canals at later stages and in adults.

Gene_expression (expression) of Kit in canals

19) Confidence 0.68 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.29 Pain Relevance 0

Consistently, KIT and KITL were found to be expressed in the rat cholangiocytes [9] and several mouse mutants of Kitl displayed comparable low post-natal viability [46,47].

Gene_expression (expressed) of KIT

20) Confidence 0.68 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.37 Pain Relevance 0

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