INT91995

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Context Info
Confidence 0.14
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.84
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
neurons 1
hippocampus 1
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 11 99.60 Very High Very High Very High
antidepressant 3 98.80 Very High Very High Very High
Hippocampus 6 96.28 Very High Very High Very High
carbamazepine 9 90.44 High High
Glutamate 34 86.44 High High
Serotonin 3 83.44 Quite High
Raphe 1 78.72 Quite High
agonist 42 77.68 Quite High
bDMF 16 63.04 Quite High
Pain 7 56.28 Quite High
Disease Link Frequency Relevance Heat
Depression 14 99.60 Very High Very High Very High
Peripheral Arterial Disease 6 99.14 Very High Very High Very High
Convulsion 11 98.42 Very High Very High Very High
Apoptosis 82 97.20 Very High Very High Very High
Shock 1 91.84 High High
Death 37 89.80 High High
Neurodegenerative Disease 10 85.28 High High
Diabetes Mellitus 4 75.00 Quite High
Increased Venous Pressure Under Development 4 75.00 Quite High
Pain 7 56.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among different potential GSK3 targets, Bax, a protein of the intrinsic apoptotic cascade that is involved in mitochondrial pore formation, has been reported to become phosphorylated and translocated to mitochondria upon GSK3 activation in granule neurons [15].
Positive_regulation (activation) of GSK3 in neurons associated with apoptosis
1) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.73 Pain Relevance 0.07
The activation of both these nucleotide receptors resulted in an increase in the phosphorylation levels of GSK3 at specific Ser residues that were associated with the inhibition of its catalytic activity [9].
Positive_regulation (increase) of GSK3
2) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
P2Y13 receptors were coupled to the well characterized PI3K/Akt dependent pathway, described for growth factors of the insulin family [10], resulting in the stabilization of the GSK3 substrate ?
Positive_regulation (stabilization) of GSK3
3) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.24 Pain Relevance 0.07
Indeed, the intracellular signals activated by NMDA, such as ERK and Akt, are partially dependent on TrkB activation, as also observed for GSK3 signalling in the present study [30].
Positive_regulation (observed) of GSK3
4) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
In subsequent experiments we analyzed in more detail the intracellular signalling mechanism of GSK3 phosphorylation induced by the three stimuli, employing inhibitors of different signal transducing proteins that can be upstream of GSK3.
Positive_regulation (upstream) of GSK3
5) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0
However, these nucleotide receptors displayed different intracellular mechanisms to reach GSK3.
Positive_regulation (reach) of GSK3
6) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.06 Pain Relevance 0.07
This evidence led to the hypothesis of an involvement of GSK-3?
Positive_regulation (involvement) of GSK-3
7) Confidence 0.05 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.45 Pain Relevance 0.36
Multiple logistic regression analysis indicated that the presence of PVD symptoms was associated more closely with increased FA-stiffness beta than with increased FA-IMT, whereas reduced ABI was associated more closely with FA-IMT than with FA-stiffness beta.
Positive_regulation (increased) of FA-stiffness beta associated with peripheral arterial disease
8) Confidence 0.02 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11500193 Disease Relevance 0.80 Pain Relevance 0.11
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Positive_regulation (line-derived) of factor in hippocampus associated with antidepressant, convulsion and hippocampus
9) Confidence 0.02 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.55 Pain Relevance 0.10

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