INT92000

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Context Info
Confidence 0.18
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 4.12
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
neurons 3
neuronal 1
nerve 1
astrocytes 1
hippocampus 1
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 14 100.00 Very High Very High Very High
Nerve growth factor 3 100.00 Very High Very High Very High
antidepressant 3 99.60 Very High Very High Very High
ischemia 133 99.16 Very High Very High Very High
withdrawal 15 97.88 Very High Very High Very High
Paracetamol 60 97.04 Very High Very High Very High
Hippocampus 9 96.28 Very High Very High Very High
Neuronal nitric oxide synthase 1 96.16 Very High Very High Very High
agonist 60 95.76 Very High Very High Very High
depression 22 93.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 17 100.00 Very High Very High Very High
Shock 4 100.00 Very High Very High Very High
Convulsion 11 99.22 Very High Very High Very High
Apoptosis 99 99.20 Very High Very High Very High
Cv Unclassified Under Development 123 99.16 Very High Very High Very High
Death 45 98.08 Very High Very High Very High
Depression 25 93.92 High High
Neurodegenerative Disease 11 87.96 High High
Aging 42 85.64 High High
Fibrosis 1 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylation levels of GSK3?
Gene_expression (levels) of GSK3
1) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.09 Pain Relevance 0.59
Following the same line of evidence, the sole expression of the dominant negative GSK3 mutant is able to rescue cortical neurons from death induced by serum deprivation [19].
Gene_expression (expression) of GSK3 in neurons associated with death
2) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.77 Pain Relevance 0.08
Among different potential GSK3 targets, Bax, a protein of the intrinsic apoptotic cascade that is involved in mitochondrial pore formation, has been reported to become phosphorylated and translocated to mitochondria upon GSK3 activation in granule neurons [15].
Gene_expression (targets) of GSK3 in neurons associated with apoptosis
3) Confidence 0.13 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.61 Pain Relevance 0.04
BDNF was the fastest and most potent signal, producing the highest levels of GSK3 phosphorylation at as early as 5 min of stimulation.
Gene_expression (producing) of GSK3
4) Confidence 0.13 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.12
In addition, GSK3 cooperates and contributes to apoptotic signalling, such as JNK activation, during trophic deprivation [16].
Gene_expression (cooperates) of GSK3 associated with apoptosis
5) Confidence 0.13 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.74 Pain Relevance 0.07
In addition, MAPKs were also involved in the survival signalling mechanism triggered by BDNF (Fig. 6).Fig. 5Effect of PKC and MAPK inhibition on GSK3 phosphorylation levels under conditions of PI3K inhibition.
Gene_expression (levels) of GSK3
6) Confidence 0.13 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.06 Pain Relevance 0
It can be observed that when suboptimal concentrations of both effectors were added together, the levels of GSK3 phosphorylation were higher with respect to that obtained with either BzATP or NMDA alone.
Gene_expression (levels) of GSK3
7) Confidence 0.12 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.15
It has been shown that the serotonergic pathway is a downstream target of GSK-3?
Gene_expression (target) of GSK-3
8) Confidence 0.06 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.45 Pain Relevance 0.35
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Gene_expression (expression) of factor in hippocampus associated with antidepressant, convulsion and hippocampus
9) Confidence 0.04 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.56 Pain Relevance 0.10
iNOS is expressed following inflammatory or growth factor stimulation of cells unlike its counterpart eNOS (endothelial nitric oxide synthase) and nNOS (neuronal nitric oxide synthase) which are constitutively expressed.
Gene_expression (expressed) of factor in neuronal associated with inflammation and neuronal nitric oxide synthase
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.17 Pain Relevance 0.22
Several immediate-early genes (c-fos, c-jun), growth factors (brain-derived neurotrophic factor, nerve growth factor), and heat shock protein 70 were overexpressed during early latent ischemia-tolerant state [212].
Gene_expression (overexpressed) of factor in nerve associated with nerve growth factor, ischemia and shock
11) Confidence 0.01 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.58 Pain Relevance 0.69
is found extensively in the brain and is a member of the epidermal growth factor (EGF) family produced by both neurons and astrocytes [223].
Gene_expression (produced) of factor in astrocytes
12) Confidence 0.01 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.06 Pain Relevance 0
is found extensively in the brain and is a member of the epidermal growth factor (EGF) family produced by both neurons and astrocytes [223].
Gene_expression (produced) of factor in neurons
13) Confidence 0.00 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.06 Pain Relevance 0

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