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Context Info
Confidence 0.31
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.23
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Smad4) nucleus (Smad4) intracellular (Smad4)
DNA binding (Smad4) protein complex (Smad4) cytoplasm (Smad4)
Anatomy Link Frequency
nucleus 2
synapse 1
Smad4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 2 86.20 High High
Somatostatin 1 81.96 Quite High
Bile 3 75.00 Quite High
peptic ulcer disease 1 55.44 Quite High
pruritus 1 53.56 Quite High
Hippocampus 16 52.64 Quite High
Neurotransmitter 4 38.16 Quite Low
Inflammation 9 8.92 Low Low
Pyramidal cell 7 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoid 8 99.46 Very High Very High Very High
Cancer 66 90.80 High High
Apoptosis 55 90.28 High High
Metastasis 13 73.20 Quite High
Disease 11 68.00 Quite High
Obstructive Jaundice 1 57.08 Quite High
Ulcers 1 55.12 Quite High
Malignant Neoplastic Disease 3 53.60 Quite High
Pruritus 1 53.56 Quite High
Jaundice 1 52.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
pathway, interact with Smad4 and translocate to the nucleus to regulate transcription of downstream target genes [20].
Smad4 Binding (interact) of in nucleus
1) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.09 Pain Relevance 0
induces a rapid activation of Smad pathway, characterized by increased phosphorylation of the regulatory Smads (Smad2/3) after 20 min, binding to Smad4 and nuclear translocation of the complex [4].
Smad4 Binding (binding) of
2) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.37 Pain Relevance 0
R-SMADs interact with SMAD-4, the only known common mediator SMAD (CoSMAD) in mammals, and form heteromeric complexes which translocate to the nucleus where they influence gene expression (by binding to the DNA and acting as transcription factors, coactivators, and corepressors) [14–17].
SMAD-4 Binding (interact) of in nucleus
3) Confidence 0.07 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0.11 Pain Relevance 0
Besides, dysbindin also binds to the dystrophin-associated protein complex (DPC), a component of the synapse (Benson et al., 2001).
DPC Binding (binds) of in synapse
4) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0 Pain Relevance 0.03
A mutation in codon 12 of K-ras was found in one carcinoid tumor whereas two of two showed immunoreactivity for Dpc4 protein.
Dpc4 protein Binding (immunoreactivity) of associated with carcinoid
5) Confidence 0.01 Published 2000 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11075851 Disease Relevance 1.66 Pain Relevance 0.27

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