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Context Info
Confidence 0.59
First Reported 1991
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 171
Total Number 172
Disease Relevance 101.61
Pain Relevance 53.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
monocyte 17
PGE2 6
joint 6
osteoblast 6
blood 5
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1891 100.00 Very High Very High Very High
cytokine 1278 100.00 Very High Very High Very High
rheumatoid arthritis 840 100.00 Very High Very High Very High
Inflammatory response 165 100.00 Very High Very High Very High
chemokine 158 100.00 Very High Very High Very High
Pain 141 100.00 Very High Very High Very High
bradykinin 27 100.00 Very High Very High Very High
qutenza 22 100.00 Very High Very High Very High
neuralgia 7 100.00 Very High Very High Very High
cINOD 173 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2370 100.00 Very High Very High Very High
Rheumatoid Arthritis 1061 100.00 Very High Very High Very High
Cancer 955 100.00 Very High Very High Very High
Obesity 457 100.00 Very High Very High Very High
Osteoporosis 393 100.00 Very High Very High Very High
Adhesions 212 100.00 Very High Very High Very High
Necrosis 175 100.00 Very High Very High Very High
Pain 108 100.00 Very High Very High Very High
Stroke 66 100.00 Very High Very High Very High
Alzheimer's Dementia 43 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antiviral effects of tenidap may be independent of its ability to reduce IL-6 production based on the observations that these effects were as prominent in IL-6 nonresponsive lines as in IL-6 responsive lines and that the inhibition of p24 production was not reversed by exogenous IL-6.
Negative_regulation (reduce) of Gene_expression (production) of IL-6
1) Confidence 0.59 Published 1997 Journal J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. Section Abstract Doc Link 8989205 Disease Relevance 0.45 Pain Relevance 0.08
Tenidap, a structurally and functionally novel antirheumatic drug affecting diverse biologic processes, has been shown to reduce IL-6 production by peripheral blood mononuclear cells stimulated with lipopolysaccharide.
Negative_regulation (reduce) of Gene_expression (production) of IL-6 in mononuclear cells
2) Confidence 0.59 Published 1997 Journal J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. Section Abstract Doc Link 8989205 Disease Relevance 0.39 Pain Relevance 0.07
Previous studies have shown that tenidap is able to inhibit the production and action of cytokines such as interleukin-1, interleukin-6 (IL-6) and tumour necrosis factor alpha.
Negative_regulation (inhibit) of Gene_expression (production) of interleukin-6 associated with necrosis, cancer and cytokine
3) Confidence 0.58 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.46 Pain Relevance 0.24
Potent inhibition of interleukin-6 expression in a human astrocytoma cell line by tenidap.
Negative_regulation (inhibition) of Gene_expression (expression) of interleukin-6 associated with anaplastic astrocytoma
4) Confidence 0.58 Published 1997 Journal Cell Tissue Res. Section Title Doc Link 9082960 Disease Relevance 0.56 Pain Relevance 0.28
We investigated in the human astrocytoma cell line U373 whether tenidap inhibits IL-6 synthesis by inhibition of certain signal transduction processes leading to IL-6 synthesis.
Spec (whether) Negative_regulation (inhibits) of Gene_expression (synthesis) of IL-6 associated with anaplastic astrocytoma
5) Confidence 0.58 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.50 Pain Relevance 0.22
Tenidap was a very potent inhibitor of IL-6 synthesis independent of the stimuli used, suggesting an inhibitory mechanism other than inhibition of a certain signal transduction pathway.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of IL-6
6) Confidence 0.58 Published 1997 Journal Cell Tissue Res. Section Abstract Doc Link 9082960 Disease Relevance 0.54 Pain Relevance 0.26
Tenidap, naproxen and meloxicam inhibited the IL-1 beta-induced synthesis of IL-6, whereas ibuprofen, piroxicam, diclofenac and indomethacin had no effect.
Negative_regulation (inhibited) of Gene_expression (synthesis) of IL-6 associated with diclofenac
7) Confidence 0.58 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.60 Pain Relevance 0.51
While the effects of naproxen and meloxicam were small and restricted to protein synthesis, tenidap strongly inhibited IL-6 protein synthesis and also affected IL-6 mRNA levels.
Negative_regulation (inhibited) of Gene_expression (synthesis) of IL-6
8) Confidence 0.58 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.55 Pain Relevance 0.50
They fully blocked PGE2 production, inhibited IL-6 synthesis, and increased aggrecan synthesis.
Negative_regulation (inhibited) of Gene_expression (synthesis) of IL-6 in PGE2
9) Confidence 0.57 Published 2002 Journal J. Rheumatol. Section Body Doc Link 11950021 Disease Relevance 0 Pain Relevance 0
Ibuprofen suppressed sputum-stimulated IL-6 production to levels above control and effect levelled off at 50-100 microg/mi, contrasting the dose-dependent suppression to control level with MK-663 (0.1-10 microg/ml) and to sub-control levels with triptolide (20-1000 ng/ml).
Negative_regulation (suppressed) of Gene_expression (production) of IL-6 in sputum
10) Confidence 0.57 Published 2004 Journal Respir Med Section Abstract Doc Link 15072174 Disease Relevance 0.84 Pain Relevance 0.36
In contrast, flurbiprofen completely abolished IL-6 production by both cell lines and substantially inhibited IL-1 beta and TNF alpha production.
Negative_regulation (abolished) of Gene_expression (production) of IL-6
11) Confidence 0.55 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1404130 Disease Relevance 0.35 Pain Relevance 0.37
Moreover, inclusion of indomethacin caused a 20% reduction in IL-6 production and totally eliminated PGE2 production.
Negative_regulation (reduction) of Gene_expression (production) of IL-6
12) Confidence 0.54 Published 1996 Journal J. Clin. Periodontol. Section Abstract Doc Link 8841895 Disease Relevance 0.17 Pain Relevance 0.23
The two drugs, at therapeutic concentrations, exerted a stimulatory effect on the synthesis of PAI-1 whereas the synthesis of IL-6 was significantly reduced by both NSAIDs.
Negative_regulation (reduced) of Gene_expression (synthesis) of IL-6
13) Confidence 0.54 Published 1997 Journal Clin. Exp. Rheumatol. Section Body Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0
Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts.
Negative_regulation (reduce) of Gene_expression (synthesis) of IL-6 in fibroblasts associated with cinod
14) Confidence 0.54 Published 1997 Journal Clin. Exp. Rheumatol. Section Title Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0.33
Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production.
Negative_regulation (decreased) of Gene_expression (production) of IL-6 in chondrocytes
15) Confidence 0.54 Published 1999 Journal Clin. Exp. Rheumatol. Section Body Doc Link 10342040 Disease Relevance 0 Pain Relevance 0
The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.
Negative_regulation (suppressed) of Gene_expression (production) of IL-6 associated with noradrenaline and clonidine
16) Confidence 0.53 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084220 Disease Relevance 0.15 Pain Relevance 0.62
Cyclooxygenase-2 inhibitors decrease interleukin-1beta-stimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts.
Negative_regulation (decrease) of Gene_expression (production) of IL-6 in fibroblasts associated with cox2
17) Confidence 0.52 Published 2003 Journal J. Periodontol. Section Title Doc Link 14974816 Disease Relevance 0.45 Pain Relevance 0.31
Estrogen's ability to repress IL-6 expression was first recognized in human endometrial stromal cells [152].
Negative_regulation (repress) of Gene_expression (expression) of IL-6 in stromal cells
18) Confidence 0.50 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 1.69 Pain Relevance 0.22
Estrogen blocks the osteoblast's synthesis of Interleukin 6.
Negative_regulation (blocks) of Gene_expression (synthesis) of Interleukin 6 in osteoblast associated with osteoporosis
19) Confidence 0.50 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 2.20 Pain Relevance 0.36
Further evidence for estrogen's ability to repress IL-6 expression is derived from studies, which demonstrated that estradiol inhibits bone marrow stromal cell and osteoblastic cell IL-6 protein and mRNA production in vitro [158] and that estradiol was as effective as neutralizing antibody to IL-6 in suppressing osteoclast development in murine bone cell cultures [159]or in ovariectomized mice [160].


Negative_regulation (repress) of Gene_expression (expression) of IL-6 in bone marrow associated with osteoporosis
20) Confidence 0.50 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 1.42 Pain Relevance 0.07

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