INT9235

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2011
Negated 15
Speculated 9
Reported most in Body
Documents 346
Total Number 355
Disease Relevance 252.98
Pain Relevance 118.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 52
monocytes 24
blood 18
T cell 17
leukocyte 16
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4577 100.00 Very High Very High Very High
cytokine 3265 100.00 Very High Very High Very High
rheumatoid arthritis 1928 100.00 Very High Very High Very High
Inflammatory response 457 100.00 Very High Very High Very High
antagonist 350 100.00 Very High Very High Very High
cva 279 100.00 Very High Very High Very High
Spinal cord 247 100.00 Very High Very High Very High
Inflammatory mediators 216 100.00 Very High Very High Very High
depression 190 100.00 Very High Very High Very High
Eae 105 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5249 100.00 Very High Very High Very High
Rheumatoid Arthritis 2046 100.00 Very High Very High Very High
Cancer 1299 100.00 Very High Very High Very High
Injury 909 100.00 Very High Very High Very High
Necrosis 663 100.00 Very High Very High Very High
Targeted Disruption 471 100.00 Very High Very High Very High
Hemorrhage 253 100.00 Very High Very High Very High
Adhesions 241 100.00 Very High Very High Very High
Depression 222 100.00 Very High Very High Very High
Diabetes Mellitus 195 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More interestingly, thalidomide has shown the ability to suppress tumor necrosis factor alpha (TNF alpha) production and to modify the expression of TNF alpha induced adhesion molecules on endothelial cells and on human leukocytes.
Negative_regulation (suppress) of Gene_expression (production) of tumor necrosis factor alpha in leukocytes associated with necrosis, cancer and adhesions
1) Confidence 0.59 Published 2002 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 12412207 Disease Relevance 0.91 Pain Relevance 0.15
Similar results were obtained using the membrane-permeable cAMP analogue db-cAMP, which caused preferential inhibition of TNFalpha expression.
Negative_regulation (inhibition) of Gene_expression (expression) of TNFalpha
2) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.17 Pain Relevance 0.25
Pentoxifilne (PTX) is a non specific inhibitor of cytokines release, which suppress mainly TNF production.
Negative_regulation (suppress) of Gene_expression (production) of TNF associated with cytokine
3) Confidence 0.58 Published 2008 Journal Folia Med Cracov Section Abstract Doc Link 20050583 Disease Relevance 0.34 Pain Relevance 0.42
Taken together these findings suggest that pentoxifylline can down-regulate TNF expression and improve the sense of well-being in cancer patients.
Negative_regulation (down) of Gene_expression (expression) of TNF associated with cancer
4) Confidence 0.58 Published 1993 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7678547 Disease Relevance 1.18 Pain Relevance 0.11
The addition of sera from healthy controls to the co-cultures was found to inhibit T cell induced production of TNF-?
Negative_regulation (inhibit) of Gene_expression (production) of TNF in T cell
5) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.80 Pain Relevance 0.36
The experiments presented here also indicate that the reduced production of TNF-?
Negative_regulation (reduced) of Gene_expression (production) of TNF
6) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.71 Pain Relevance 0.46
As for mechanisms of action, KT-90 and morphine induced apoptosis, and inhibited tumor necrosis factor alpha (TNF-alpha) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF-kappaB DNA binding activity.
Negative_regulation (inhibited) of Gene_expression (expression) of tumor necrosis factor alpha associated with necrosis, cancer, apoptosis and morphine
7) Confidence 0.57 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9837747 Disease Relevance 0.65 Pain Relevance 0.79
In fact, a decrease in TNF RI gene and protein expression was seen in degenerate and herniated IVDs compared to non-degenerate IVDs, suggesting that the biological activity of TNF?
Negative_regulation (decrease) of Gene_expression (expression) of TNF
8) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206382 Disease Relevance 0 Pain Relevance 0.03
It suppresses the human leukocyte elasetase activity and inhibits the production of proinflammatory cytokines, such as TNF-?
Negative_regulation (inhibits) of Gene_expression (production) of TNF in leukocyte associated with cytokine
9) Confidence 0.57 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876852 Disease Relevance 1.67 Pain Relevance 0.78
For instance, 2-AG inhibits the production of TNF-?
Negative_regulation (inhibits) of Gene_expression (production) of TNF
10) Confidence 0.57 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2631501 Disease Relevance 0.78 Pain Relevance 0.14
IL-4 inhibits the activation of Th1 cells, which in turn decreases the production of TNF-?
Negative_regulation (decreases) of Gene_expression (production) of TNF in Th1 cells
11) Confidence 0.57 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 0.95 Pain Relevance 0.40
Pretreatment with BQ-123 or BQ-788 (i.a.; 15 pmol/cavity) also decreased zymosan-induced TNF-alpha production within 6 h, keratinocyte-derived chemokine/CXCL1 production within 24 h, and leukotriene B(4) at both time-points.
Negative_regulation (decreased) of Gene_expression (production) of TNF-alpha in keratinocyte associated with chemokine
12) Confidence 0.57 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18515326 Disease Relevance 1.12 Pain Relevance 0.50
In the ferret model with 27% mortality based on the >20% weight loss following infection with A/California/07/2009 pandemic influenza virus [22], sequential lung sampling documented decreased gene expression of CCL2, CXCL10, TNFA and IL1B on day 7 when animals show highest weight loss.
Negative_regulation (decreased) of Gene_expression (expression) of TNF in lung associated with weight loss, influenza virus infection and infection
13) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.04 Pain Relevance 0.21
Prostaglandin E3 also inhibits the synthesis of TNF-?
Negative_regulation (inhibits) of Gene_expression (synthesis) of TNF
14) Confidence 0.57 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 1.06 Pain Relevance 0.48
In animal models, bacterial PAMP, such as lipopolysaccharide (a TLR4 ligand), have been used to stimulate macrophages in older mice; the results have shown decreased expression of proinflammatory cytokines: TNF-?
Negative_regulation (decreased) of Gene_expression (expression) of TNF in macrophages associated with cytokine
15) Confidence 0.57 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.54 Pain Relevance 0.14
In vivo studies with BMS-470539 demonstrated that subcutaneous administration of BMS-470539 resulted in a dose-dependent inhibition of LPS-induced TNF-alpha production in BALB/c mice.
Negative_regulation (inhibition) of Gene_expression (production) of TNF-alpha
16) Confidence 0.57 Published 2006 Journal J. Leukoc. Biol. Section Abstract Doc Link 16888084 Disease Relevance 0.52 Pain Relevance 0.41
In 1988, Jacob and McDevitt [9] reported that NZB/W mice showed diminished production of TNF, a defect stemming from the otherwise healthy NZW parent, and proved that NZB/W disease was at least partly reversible by administration of recombinant TNF early in life.
Negative_regulation (diminished) of Gene_expression (production) of TNF associated with disease
17) Confidence 0.56 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374473 Disease Relevance 1.62 Pain Relevance 0.07
The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.
Negative_regulation (suppressed) of Gene_expression (production) of TNF alpha associated with noradrenaline and clonidine
18) Confidence 0.56 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084220 Disease Relevance 0.13 Pain Relevance 0.61
Among the various agents, (-)-epigallocatechin gallate (EGCG) and green tea polyphenols inhibited TNF-alpha gene expression in the cells induced by tumor promoter, mediated through inhibition of NF-kappaB activation.
Negative_regulation (inhibited) of Gene_expression (expression) of TNF-alpha associated with cancer
19) Confidence 0.56 Published 2002 Journal Mech. Ageing Dev. Section Abstract Doc Link 12470903 Disease Relevance 1.27 Pain Relevance 0.51
Flurbiprofen caused moderate inhibition of IL-1 beta and TNF alpha production by stimulated monocytes, but did not affect IL-6 production.
Negative_regulation (inhibition) of Gene_expression (production) of TNF alpha in monocytes
20) Confidence 0.56 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1404130 Disease Relevance 0.38 Pain Relevance 0.39

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