INT92355

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Marcks) cytoplasm (Marcks)
Anatomy Link Frequency
LGN 2
synapses 1
neurites 1
Marcks (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 12 100.00 Very High Very High Very High
narcan 2 99.72 Very High Very High Very High
tetrodotoxin 2 99.28 Very High Very High Very High
Clonidine 7 98.32 Very High Very High Very High
tramadol 9 95.60 Very High Very High Very High
butorphanol 7 94.80 High High
gABA 4 82.92 Quite High
opioid receptor 1 78.88 Quite High
substance P 2 76.96 Quite High
Opioid 1 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After monocular deprivation for 5 to 30 days, MARCKS mRNA was down-regulated in the LGN, but not in area 17.
Negative_regulation (deprivation) of MARCKS in LGN
1) Confidence 0.48 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.28
Naloxone reversed the reductions in MACs.
Negative_regulation (reductions) of MACs associated with narcan
2) Confidence 0.37 Published 2008 Journal J. Am. Vet. Med. Assoc. Section Abstract Doc Link 18598152 Disease Relevance 0 Pain Relevance 1.48
After monocular deprivation for 5 to 30 days, MARCKS mRNA was down-regulated in the LGN, but not in area 17.
Negative_regulation (down-regulated) of MARCKS in LGN
3) Confidence 0.35 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.27
We performed in situ hybridization histochemistry on the monkey basal ganglia to investigate the mRNA localization of three protein kinase C substrates (GAP-43, MARCKS, and neurogranin), of which expression plays a role in structural changes in neurites and synapses.
Spec (investigate) Negative_regulation (localization) of MARCKS in neurites associated with kinase c
4) Confidence 0.22 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17029258 Disease Relevance 0 Pain Relevance 0.23
We performed in situ hybridization histochemistry on the monkey basal ganglia to investigate the mRNA localization of three protein kinase C substrates (GAP-43, MARCKS, and neurogranin), of which expression plays a role in structural changes in neurites and synapses.
Spec (investigate) Negative_regulation (localization) of MARCKS in synapses associated with kinase c
5) Confidence 0.08 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17029258 Disease Relevance 0 Pain Relevance 0.23
The MACEIs and MACs decreased dose-dependently.
Negative_regulation (decreased) of MACs
6) Confidence 0.06 Published 2000 Journal Br J Anaesth Section Abstract Doc Link 11094583 Disease Relevance 0 Pain Relevance 0.58

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