INT9239

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2010
Negated 19
Speculated 18
Reported most in Abstract
Documents 106
Total Number 124
Disease Relevance 75.24
Pain Relevance 36.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
monocyte 13
plasma 10
blood 10
cartilage 6
adipocyte 6
IL6 (Homo sapiens)
IL6 - R753Q (1)
Pain Link Frequency Relevance Heat
cytokine 1603 100.00 Very High Very High Very High
Inflammation 1381 100.00 Very High Very High Very High
imagery 270 100.00 Very High Very High Very High
Osteoarthritis 256 100.00 Very High Very High Very High
antagonist 133 100.00 Very High Very High Very High
cINOD 86 100.00 Very High Very High Very High
agonist 85 100.00 Very High Very High Very High
dexamethasone 64 100.00 Very High Very High Very High
qutenza 29 100.00 Very High Very High Very High
lidocaine 24 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1817 100.00 Very High Very High Very High
Cancer 757 100.00 Very High Very High Very High
Osteoarthritis 261 100.00 Very High Very High Very High
Radiation Pneumonitis 224 100.00 Very High Very High Very High
Stress 143 100.00 Very High Very High Very High
Necrosis 133 100.00 Very High Very High Very High
Adhesions 70 100.00 Very High Very High Very High
Adenocarcinoma 61 100.00 Very High Very High Very High
Yersinia Infection 18 100.00 Very High Very High Very High
Renal Disease 13 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the effects of seven non-steroidal anti-inflammatory drugs (NSAIDs) on interleukin-1 beta (IL-1 beta)-induced IL-6 mRNA expression and protein synthesis in a human astrocytoma cell line were investigated.
Spec (investigated) Regulation (effects) of Gene_expression (synthesis) of IL-6 associated with anaplastic astrocytoma, inflammation and cinod
1) Confidence 0.61 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.65 Pain Relevance 0.51
In this study we investigated at cellular level the influence of two anti-inflammatory drugs-dexamethasone and indomethacin--and an experimental specific cyclooxygenase-2 inhibitor, BF389, on the production of the pro-inflammatory cytokine IL-6 and the inflammatory mediator PGE2 by human astrocytes.
Spec (investigated) Regulation (influence) of Gene_expression (production) of IL-6 in astrocytes associated with inflammation, cinod, dexamethasone and cytokine
2) Confidence 0.60 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 1.01 Pain Relevance 0.57
In order to clarify whether or not TRPV1 acts as a functional receptor, we examined the effects of capsaicin on the production of IL-6 from primary cultured human airway epithelial cells at both protein and mRNA levels.
Spec (examined) Regulation (effects) of Gene_expression (production) of IL-6 in epithelial cells associated with qutenza
3) Confidence 0.60 Published 2007 Journal Life Sci. Section Abstract Doc Link 17306835 Disease Relevance 0.17 Pain Relevance 0.52
Apart from dexamethasone, the other drugs exerted inhibitory effects on IL-6 production.
Regulation (effects) of Gene_expression (production) of IL-6 associated with dexamethasone
4) Confidence 0.60 Published 2004 Journal Respir Med Section Abstract Doc Link 15072174 Disease Relevance 0.85 Pain Relevance 0.36
In vitro study of regulation of IL-6 production in bronchiectasis.
Regulation (regulation) of Gene_expression (production) of IL-6 associated with bronchiectasis
5) Confidence 0.60 Published 2004 Journal Respir Med Section Title Doc Link 15072174 Disease Relevance 0.91 Pain Relevance 0.35
Flurbiprofen caused moderate inhibition of IL-1 beta and TNF alpha production by stimulated monocytes, but did not affect IL-6 production.
Neg (not) Regulation (affect) of Gene_expression (production) of IL-6 in monocytes
6) Confidence 0.58 Published 1992 Journal J. Rheumatol. Section Abstract Doc Link 1404130 Disease Relevance 0.36 Pain Relevance 0.38
Furthermore, expression of IL-6 and COX-2 genes in this cell seems to be differentially regulated by cytokines through prostaglandin-dependent and -independent pathways.
Regulation (regulated) of Gene_expression (expression) of IL-6 associated with cytokine
7) Confidence 0.55 Published 2002 Journal J Endod Section Abstract Doc Link 12017180 Disease Relevance 0.34 Pain Relevance 0.37
Role of endogenous pro-enkephalin A-derived peptides in human T cell proliferation and monocyte IL-6 production.
Regulation (Role) of in T cell Gene_expression (production) of IL-6 in monocyte associated with enkephalin and cytokine
8) Confidence 0.52 Published 1998 Journal J. Neuroimmunol. Section Title Doc Link 9600708 Disease Relevance 0 Pain Relevance 1.50
We investigated the effects of lidocaine on activated human umbilical vein endothelial cell (HUVEC) interleukin (IL)-1beta, IL-6, and IL-8 concentrations and intercellular adhesion molecule-1 (ICAM-1) expression.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of IL-6 in endothelial cell associated with lidocaine and adhesions
9) Confidence 0.47 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.46 Pain Relevance 0.42
Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined.
Regulation (Effects) of Gene_expression (levels) of interleukin-6 associated with nociception, stress, qutenza and inflammatory stimuli
10) Confidence 0.45 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 14651947 Disease Relevance 0.62 Pain Relevance 0.38
Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined.
Regulation (Effects) of Gene_expression (levels) of IL-6 associated with nociception, stress, qutenza and inflammatory stimuli
11) Confidence 0.45 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 14651947 Disease Relevance 0.62 Pain Relevance 0.38
The results confirm that changes in parameters such as ATP viability, cytokine expression (IL-6), cell proliferation (alkaline phosphatase enzyme activity) and DNA damage can be observed directly after the laser irradiation.
Regulation (changes) of Gene_expression (expression) of IL-6
12) Confidence 0.45 Published 2008 Journal Photodermatol Photoimmunol Photomed Section Body Doc Link 18717961 Disease Relevance 0 Pain Relevance 0
The effects of a muscle resistance program on the functional capacity, knee extensor muscle strength and plasma levels of IL-6 and TNF-?
Regulation (effects) of Gene_expression (levels) of IL-6 in plasma
13) Confidence 0.44 Published 2010 Journal Trials Section Title Doc Link PMC2919525 Disease Relevance 0.48 Pain Relevance 0.08
Given this information, it can be postulated that interventions that promote the strengthening of large muscle groups may modify the plasma levels of IL-6 and TNF-?
Spec (may) Regulation (modify) of Gene_expression (levels) of IL-6 in plasma
14) Confidence 0.44 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.33 Pain Relevance 0.15
However, the literature is unanimous in pointing out that new studies should be conducted to verify the type of muscle contraction and the ideal intensity and duration of an exercise program to increase muscle strength, and to investigate its impact on the plasma levels of IL-6 and TNF-?
Spec (investigate) Regulation (impact) of Gene_expression (levels) of IL-6 in muscle
15) Confidence 0.44 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.56 Pain Relevance 0.13
We found no association between serum IL-1beta level and age, sex, consumption of cardioactive drugs and serum levels of IL-1Ra, IL-6, sIL-6R, IL-10 and TNF-alpha.
Neg (no) Regulation (association) of Gene_expression (levels) of IL-6
16) Confidence 0.44 Published 2003 Journal Cytokine Section Abstract Doc Link 12890453 Disease Relevance 0.40 Pain Relevance 0.17
Effects of nimesulide and sodium diclofenac on interleukin-6, interleukin-8, proteoglycans and prostaglandin E2 production by human articular chondrocytes in vitro.
Regulation (Effects) of Gene_expression (production) of interleukin-6 in chondrocytes associated with diclofenac
17) Confidence 0.44 Published 1999 Journal Clin. Exp. Rheumatol. Section Title Doc Link 10342040 Disease Relevance 0.10 Pain Relevance 0.33
We aimed to determine the action of sputum from patients with bronchiectasis on IL-6 production from cultured normal human bronchial epithelial (NHBE) cells and its modulation by anti-inflammatory drugs in vitro.
Regulation (modulation) of Gene_expression (production) of IL-6 in sputum associated with inflammation, bronchiectasis and cinod
18) Confidence 0.44 Published 2004 Journal Respir Med Section Abstract Doc Link 15072174 Disease Relevance 0.95 Pain Relevance 0.36
For co-immunofluorescent staining for Pax7 and IL-6, Pax7 and IL-6R?
Regulation (immunofluorescent) of Gene_expression (staining) of IL-6
19) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
The pleiotropic roles of IL-6 appear to be dependent on the stimuli, nature of the immune and local tissue responses, and the temporal expression of IL-6 in inducing different phenotypic traits [17], [21], [23].
Regulation (dependent) of Gene_expression (expression) of IL-6
20) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.35 Pain Relevance 0

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