INT92446

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.68
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TACR1) cytoplasm (TACR1) signal transducer activity (TACR1)
Anatomy Link Frequency
blood vessels 2
neurons 2
lymphocytes 2
TACR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 16 100.00 Very High Very High Very High
Inflammation 9 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
Morphine 17 99.98 Very High Very High Very High
Chronic pancreatitis 9 99.76 Very High Very High Very High
Pain 13 99.16 Very High Very High Very High
opioid receptor 3 97.68 Very High Very High Very High
antagonist 3 95.68 Very High Very High Very High
Neuropeptide 3 90.64 High High
Rostral ventrolateral medulla 1 90.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 100.00 Very High Very High Very High
Pancreatitis 9 99.76 Very High Very High Very High
Complex Regional Pain Syndromes 2 99.52 Very High Very High Very High
Hypertension 3 98.24 Very High Very High Very High
Pain 9 94.16 High High
Stress 2 90.68 High High
Anxiety Disorder 1 87.00 High High
Depression 1 86.64 High High
Adverse Drug Reaction 1 84.12 Quite High
Sleep Disorders 1 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of NK-1R in inflammatory cells and blood vessels also points to an interaction of immunoreactive substance P nerves, inflammatory cells and blood vessels, and further supports the existence of a neuroimmune interaction that probably influences the pain syndrome and chronic inflammatory changes so characteristic of CP.
Positive_regulation (supports) of Gene_expression (expression) of NK-1R in blood vessels associated with pain, inflammation, chronic pancreatitis and substance p
1) Confidence 0.35 Published 2001 Journal Pain Section Abstract Doc Link 11275376 Disease Relevance 1.90 Pain Relevance 1.65
In addition, morphine induced SP receptor (NK-1R) expression in human lymphocytes.
Positive_regulation (induced) of Gene_expression (expression) of NK-1R in lymphocytes associated with substance p and morphine
2) Confidence 0.23 Published 2000 Journal Cell. Immunol. Section Abstract Doc Link 11104584 Disease Relevance 0.08 Pain Relevance 1.36
Morphine enhanced NK-1R expression in the cortical neurons at both the mRNA and protein levels.
Positive_regulation (enhanced) of Gene_expression (expression) of NK-1R in neurons associated with morphine
3) Confidence 0.07 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16983662 Disease Relevance 0.35 Pain Relevance 1.21
Centrally acting imidazoline I1-receptor agonists: do they have a place in the management of hypertension?
Positive_regulation (acting) of Gene_expression (agonists) of I1-receptor associated with hypertension and agonist
4) Confidence 0.00 Published 2001 Journal Am J Cardiovasc Drugs Section Title Doc Link 14728014 Disease Relevance 0.35 Pain Relevance 0.29

General Comments

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