INT9257

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.57
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELPLG) plasma membrane (SELPLG)
Anatomy Link Frequency
lymphocytes 1
Knee 1
SELPLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 105 96.92 Very High Very High Very High
Angina 5 91.48 High High
ischemia 14 88.08 High High
metalloproteinase 1 79.48 Quite High
cytokine 13 79.12 Quite High
chemokine 1 76.44 Quite High
Inflammation 32 72.64 Quite High
fibrosis 1 67.88 Quite High
lidocaine 2 12.12 Low Low
psoriasis 35 5.48 Low Low
Disease Link Frequency Relevance Heat
Adhesions 4 100.00 Very High Very High Very High
Psoriasis 45 99.24 Very High Very High Very High
Thrombosis 3 99.20 Very High Very High Very High
Pathologic Constriction 22 98.04 Very High Very High Very High
Seronegative Spondarthritis 92 96.92 Very High Very High Very High
Myocardial Infarction 8 96.72 Very High Very High Very High
Stress 42 95.28 Very High Very High Very High
Cv General 3 Under Development 5 91.48 High High
Cv Unclassified Under Development 20 88.08 High High
Hypercalcemia 2 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of IgG CLa were increased in 78% of patients with history of MI and in 32% without MI history.
Positive_regulation (increased) of CLa
1) Confidence 0.45 Published 1992 Journal Kardiologiia Section Abstract Doc Link 1405256 Disease Relevance 0.95 Pain Relevance 0.42
Interestingly the concomitant increase of CD16:2/CLA and DIN/IP ratios are suggestive of an increased peroxisomal beta oxidation as a physiological response to oxidative stress resulting in a decrease of PUFAHP and IP 2 hours after reperfusion.
Positive_regulation (increase) of CLA associated with stress
2) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.54 Pain Relevance 0.12
The ratios CD 16:2/CLA and DIN/IP (figure 3) increased significantly in a similar fashion as PUFAHP and IP.
Positive_regulation (increased) of CLA
3) Confidence 0.14 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.31 Pain Relevance 0
For example, cutaneous lymphocyte associated (CLA) antigen, an adhesion molecule that identifies lymphocytes that preferentially traffic to the skin, is upregulated on lymphocytes in psoriatic skin but is minimally expressed on cells in the PsA synovium [36].


Positive_regulation (upregulated) of CLA in lymphocytes associated with psoriasis, adhesions and arthritis
4) Confidence 0.11 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.27 Pain Relevance 0.52
Normally, naturally increase in 9c,11t-CLA in milk also results in increased concentration of VA [85].
Positive_regulation (increase) of CLA
5) Confidence 0.05 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2039733 Disease Relevance 0.50 Pain Relevance 0.11
Knee extension strength was the only strength outcome that showed a sex difference with greater increases for women on CrM+CLA after training compared to all other groups.
Positive_regulation (increases) of CLA in Knee
6) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994592 Disease Relevance 0 Pain Relevance 0

General Comments

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