INT92590

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1R) plasma membrane (IGF1R)
Anatomy Link Frequency
Caco-2 2
IGF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 92.72 High High
cINOD 1 71.44 Quite High
Chronic pancreatitis 1 25.00 Low Low
COX2 1 25.00 Low Low
Bile 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 3 99.80 Very High Very High Very High
Malignant Neoplastic Disease 5 98.92 Very High Very High Very High
Cholangiocarcinoma 74 94.00 High High
Adenocarcinoma 7 84.80 Quite High
Colon Cancer 4 84.48 Quite High
Apoptosis 15 76.08 Quite High
Cancer 29 71.52 Quite High
INFLAMMATION 2 71.20 Quite High
Carcinoma 6 67.08 Quite High
Colorectal Cancer 9 28.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been postulated that c-Src may induce transformation by causing the overexpression of the insulinlike growth factor-1 receptor (IGF-1R) in pancreatic tumor cell lines.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-1R associated with pancreatic cancer
1) Confidence 0.57 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14627343 Disease Relevance 0.51 Pain Relevance 0
Up-regulation of COX-2 expression by IGF-II is mediated through activation of IGF-I receptor because: (i) treatment of Caco-2 cells with a blocking antibody to the IGF-I receptor inhibits COX-2 mRNA expression; (ii) transfection of Caco-2 cells with a dominant negative IGF-I receptor reduces COX-2 expression and activity.
Positive_regulation (transfection) of Gene_expression (transfection) of IGF-I receptor in Caco-2
2) Confidence 0.38 Published 2000 Journal Oncogene Section Abstract Doc Link 11114729 Disease Relevance 0.44 Pain Relevance 0.07
Increased expression of IGF1R promotes ligand-dependent malignant transformation in various cell systems [48].
Positive_regulation (Increased) of Gene_expression (expression) of IGF1R associated with malignant neoplastic disease
3) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.36 Pain Relevance 0.05

General Comments

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