INT92797

From wiki-pain
Revision as of 22:50, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2000
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.81
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) transport (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
spinal cord 1
striatum 1
hippocampus 1
Arrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 13 99.74 Very High Very High Very High
opioid receptor 24 99.56 Very High Very High Very High
tail-flick 1 99.48 Very High Very High Very High
Morphine 14 98.80 Very High Very High Very High
Kappa opioid receptor 2 97.64 Very High Very High Very High
Hippocampus 4 96.72 Very High Very High Very High
Spinal cord 2 96.64 Very High Very High Very High
Antinociceptive 2 94.92 High High
tolerance 5 94.28 High High
Physical dependence 1 92.76 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.96 Very High Very High Very High
Drug Dependence 1 92.76 High High
Pain 2 84.16 Quite High
Ganglion Cysts 2 75.00 Quite High
Urological Neuroanatomy 4 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a knockout mouse lacking beta-arrestin-2 (beta arr2-/-), we have assessed the contribution of desensitization of the mu-opioid receptor to the development of morphine antinociceptive tolerance and the subsequent onset of physical dependence.
Regulation (lacking) of beta-arrestin-2 associated with targeted disruption, physical dependence, tolerance, opioid receptor, antinociceptive and morphine
1) Confidence 0.44 Published 2000 Journal Nature Section Abstract Doc Link 11130073 Disease Relevance 0.35 Pain Relevance 1.22
In the present study, we examined the effects of pretreatment with beta-arrestin-2 antibody on tail-flick inhibition induced by opioid receptor agonists in the mouse spinal cord.
Spec (examined) Regulation (effects) of beta-arrestin-2 in spinal cord associated with agonist, tail-flick, opioid receptor and spinal cord
2) Confidence 0.40 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12850536 Disease Relevance 0 Pain Relevance 0.88
We propose that beta-arrestin2 is required to target c-Src to constitutively active mu receptors, resulting in their internalization, providing another dimension to the complex role of beta-arrestin2 and c-Src in G-protein-coupled receptor function.
Regulation (role) of beta-arrestin2
3) Confidence 0.27 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17494695 Disease Relevance 0.07 Pain Relevance 0.25
Furthermore, a single, distinct, and highly significant quantitative trait locus for Arrb2 expression in hippocampus and striatum was identified at the locus of this gene, providing evidence that genetic variation may affect a cis-regulatory mechanism for expression and regional control of Arrb2.
Regulation (control) of Arrb2 in striatum associated with hippocampus
4) Confidence 0.26 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.18
DOPr agonists also had no effect on miniature IPSCs in beta-arrestin-2 knock-out mice after chronic morphine.
Neg (no) Regulation (effect) of beta-arrestin-2 associated with targeted disruption, agonist, opioid receptor and morphine
5) Confidence 0.20 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15788776 Disease Relevance 0.38 Pain Relevance 1.57
Furthermore, a single, distinct, and highly significant quantitative trait locus for Arrb2 expression in hippocampus and striatum was identified at the locus of this gene, providing evidence that genetic variation may affect a cis-regulatory mechanism for expression and regional control of Arrb2.
Regulation (control) of Arrb2 in hippocampus associated with hippocampus
6) Confidence 0.09 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox