INT92822

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 36
Total Number 39
Disease Relevance 29.50
Pain Relevance 8.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
plasma 6
joint 6
blood 4
hepatocytes 2
platelet 2
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 533 100.00 Very High Very High Very High
cytokine 99 100.00 Very High Very High Very High
Inflammatory marker 67 100.00 Very High Very High Very High
rheumatoid arthritis 114 99.80 Very High Very High Very High
Opioid 6 99.52 Very High Very High Very High
bradykinin 2 99.36 Very High Very High Very High
methotrexate 66 99.12 Very High Very High Very High
adenocard 2 99.12 Very High Very High Very High
sSRI 9 99.10 Very High Very High Very High
imagery 84 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 674 100.00 Very High Very High Very High
Disease 418 100.00 Very High Very High Very High
Cancer 22 100.00 Very High Very High Very High
Necrosis 21 100.00 Very High Very High Very High
Weight Loss 20 99.96 Very High Very High Very High
Acute Coronary Syndrome 40 99.84 Very High Very High Very High
Rheumatoid Arthritis 116 99.80 Very High Very High Very High
Cardiovascular Disease 93 99.54 Very High Very High Very High
Osteomyelitis 2 99.48 Very High Very High Very High
Hyperlipidemia 22 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, we determined that the inhibition of CRP expression was because of a dose-dependent inhibition of phosphorylation and degradation of inhibitor kappaB(I-kappaB), which resulted in a reduction of p65NF-kappaB nuclear translocation.
Negative_regulation (inhibition) of Gene_expression (expression) of CRP
1) Confidence 0.49 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.39 Pain Relevance 0.36
In contrast, our patient's commencement on quetiapine treatment, while her SSRI medication was maintained, was related to a reduction in her CRP levels and a clinical improvement in all other areas.
Negative_regulation (reduction) of Gene_expression (levels) of CRP associated with ssri
2) Confidence 0.43 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2821395 Disease Relevance 1.17 Pain Relevance 0.67
[Fluctuation of C-reactive protein levels in acute coronary syndrome].
Negative_regulation ([Fluctuation) of Gene_expression (levels) of C-reactive protein associated with acute coronary syndrome
3) Confidence 0.40 Published 2005 Journal Georgian Med News Section Title Doc Link 16369062 Disease Relevance 0.43 Pain Relevance 0.13
Berberine also reduced the levels of expression of mRNA for pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha, IL-6, CRP and haptoglobin [20].
Negative_regulation (reduced) of Gene_expression (expression) of CRP associated with necrosis, inflammation, cancer and cytokine
4) Confidence 0.40 Published 2009 Journal Nutr J Section Body Doc Link PMC2739863 Disease Relevance 1.27 Pain Relevance 0.28
In patients with diabetes and hypercholesterolemia, simvastatin combined with the angiotensin converting enzyme (ACE) inhibitor ramipril significantly reduced CRP levels more than monotherapy (Koh et al 2005b).
Negative_regulation (reduced) of Gene_expression (levels) of CRP associated with diabetes mellitus and hyperlipidemia
5) Confidence 0.39 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.23 Pain Relevance 0.17
Although a correlation was found between CRP levels and DeltaT (R=0.29, P<0.01), in certain groups a discrepancy between CRP levels and DeltaT was observed.
Negative_regulation (discrepancy) of Gene_expression (levels) of CRP
6) Confidence 0.36 Published 2007 Journal Atherosclerosis Section Abstract Doc Link 16820148 Disease Relevance 1.43 Pain Relevance 0.57
The results indicated that puerarin inhibited the expression of the protein and mRNA levels of CRP in LPS-induced peripheral blood mononuclear cells.
Negative_regulation (inhibited) of Gene_expression (expression) of CRP in mononuclear cells
7) Confidence 0.36 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.41 Pain Relevance 0.37
Within each CRP subgroup (?
Negative_regulation (Within) of Gene_expression (subgroup) of CRP
8) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911906 Disease Relevance 0.10 Pain Relevance 0.10
Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris.
Negative_regulation (suppression) of Gene_expression (expression) of C-reactive protein in blood associated with stable angina pectoris and angina
9) Confidence 0.35 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Title Doc Link 20346059 Disease Relevance 0.41 Pain Relevance 0.32
Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris.
Negative_regulation (inhibits) of Gene_expression (expression) of C-reactive protein in blood associated with stable angina pectoris and angina
10) Confidence 0.35 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Title Doc Link 20346059 Disease Relevance 0.41 Pain Relevance 0.32
Fenofibrate lowered hsCRP levels in patients with hypertriglyceridemia or combined hyperlipidemia (Koh et al 2005a).
Negative_regulation (lowered) of Gene_expression (levels) of hsCRP associated with hyperlipidemia
11) Confidence 0.34 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.31 Pain Relevance 0.10
Exercise training, together with weight loss, reduced hsCRP levels significantly, although not in proportion to weight reduction (Obisesan et al 2004).
Negative_regulation (reduced) of Gene_expression (levels) of hsCRP associated with weight loss
12) Confidence 0.34 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 1.23 Pain Relevance 0.18
So is CRP good or bad?
Negative_regulation (is) of Gene_expression (good) of CRP
13) Confidence 0.32 Published 2004 Journal Crit Care Section Body Doc Link PMC420058 Disease Relevance 0.67 Pain Relevance 0.10
CRP levels were ?
Negative_regulation (were) of Gene_expression (levels) of CRP
14) Confidence 0.32 Published 2004 Journal Crit Care Section Body Doc Link PMC420058 Disease Relevance 0.78 Pain Relevance 0
Statin treatment appears to reduce vascular expression of CRP and TF.


Spec (appears) Negative_regulation (reduce) of Gene_expression (expression) of CRP
15) Confidence 0.32 Published 2009 Journal Atherosclerosis Section Body Doc Link 18508060 Disease Relevance 0.12 Pain Relevance 0
It was concluded that in addition to the established involvement of adenosine, bradykinin, opioid and other receptors, a suppression of myocardial CRP/complement production might be involved in the biological mechanism of preconditioning.
Negative_regulation (suppression) of Gene_expression (production) of CRP associated with adenocard, opioid and bradykinin
16) Confidence 0.24 Published 2004 Journal Life Sci. Section Abstract Doc Link 15193950 Disease Relevance 0.77 Pain Relevance 0.48
The circulating levels of CRP, SAA, and HSP70 decreased in elderly women in response to the present exercise training program (Table 3).
Negative_regulation (decreased) of Gene_expression (levels) of CRP
17) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3022197 Disease Relevance 0.66 Pain Relevance 0.21
It has also been reported that genetics associated with reduced CRP production predispose to the development of systemic lupus erytematosus [35].
Negative_regulation (reduced) of Gene_expression (production) of CRP associated with systemic lupus erythematosus
18) Confidence 0.22 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2885391 Disease Relevance 1.65 Pain Relevance 0
In all patients, Spearman Rank correlation coefficients among baseline biomarker levels showed a strong and statistically significant relationship between IL-6 and CRP levels (0.698, p<0.001).
Negative_regulation (relationship) of Gene_expression (levels) of CRP
19) Confidence 0.17 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564765 Disease Relevance 0.19 Pain Relevance 0.30
Thus, decreases from baseline to week 2 and 24 in IL-6, CRP and VEGF levels were significantly correlated with improvement in MRI activity and BASDAI scores.
Negative_regulation (decreases) of Gene_expression (levels) of CRP associated with imagery
20) Confidence 0.17 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564765 Disease Relevance 0.15 Pain Relevance 0.41

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