INT92839

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 36
Total Number 41
Disease Relevance 13.19
Pain Relevance 15.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
neurons 4
dorsal root ganglia 3
plasma 1
P19 1
spinal nerve 1
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 115 100.00 Very High Very High Very High
Inflammation 51 100.00 Very High Very High Very High
Cannabinoid 18 100.00 Very High Very High Very High
addiction 6 100.00 Very High Very High Very High
vanilloid receptor subtype 1 2 100.00 Very High Very High Very High
Kinase C 367 99.92 Very High Very High Very High
agonist 180 99.84 Very High Very High Very High
Neurotransmitter 32 99.70 Very High Very High Very High
qutenza 21 99.60 Very High Very High Very High
Analgesic 15 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 176 99.32 Very High Very High Very High
Pain 191 99.04 Very High Very High Very High
Nervous System Injury 81 99.00 Very High Very High Very High
Ganglion Cysts 308 98.84 Very High Very High Very High
INFLAMMATION 55 98.80 Very High Very High Very High
Nociception 141 98.44 Very High Very High Very High
Embryonal Carcinoma 14 98.16 Very High Very High Very High
Hypersensitivity 20 98.08 Very High Very High Very High
Hyperalgesia 29 97.84 Very High Very High Very High
Convulsion 6 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, there is significant interest in a better understanding of the mechanisms involved in the short-term and long-term regulation of P2X receptors.
Regulation (regulation) of P2X
1) Confidence 0.45 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0.09 Pain Relevance 0.41
We have examined the effect of cannabinoids on the slow P2X2 and P2X2/3 receptors in the cells isolated from nodosal and dorsal root ganglia of rat.
Spec (examined) Regulation (effect) of P2X2 in dorsal root ganglia associated with cannabinoid
2) Confidence 0.44 Published 2006 Journal Pflugers Arch. Section Abstract Doc Link 16741755 Disease Relevance 0.38 Pain Relevance 0.38
We have examined the effect of cannabinoids on the slow P2X2 and P2X2/3 receptors in the cells isolated from nodosal and dorsal root ganglia of rat.
Spec (examined) Regulation (effect) of P2X2 in dorsal root ganglia associated with cannabinoid
3) Confidence 0.44 Published 2006 Journal Pflugers Arch. Section Abstract Doc Link 16741755 Disease Relevance 0.38 Pain Relevance 0.41
P2X receptors, particularly the P2X(3) subtype, are identified as targets for novel analgesics.
Regulation (targets) of P2X associated with analgesic
4) Confidence 0.37 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 0.91 Pain Relevance 0.53
Functional data supporting a role of PKC in P2X receptor regulation have been detailed above.
Regulation (regulation) of P2X associated with kinase c
5) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.44
Evidence against a control of P2X receptor channel function by PKC-mediated phosphorylation
Regulation (function) of P2X associated with kinase c
6) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.26
P2X receptors, particularly the P2X(3) subtype, are identified as targets for novel analgesics.
Regulation (targets) of P2X associated with analgesic
7) Confidence 0.32 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 0.91 Pain Relevance 0.53
Close to the FT motif is a nearby conserved lysine residue that has been shown to be involved in regulating ATP potency (Lys190 in P2X1 and Lys188 in P2X2 that when mutated to alanine resulted in ?
Regulation (regulating) of P2X2 associated with potency
8) Confidence 0.32 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2459275 Disease Relevance 0 Pain Relevance 0.39
Protons can also regulate P2X receptors with the effect dependent on the channel subtype (Stoop et al., 1997).
Regulation (regulate) of P2X
9) Confidence 0.29 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.12
It is unclear how phosphorylation of the conserved PKA site changes P2X receptor activity.
Regulation (changes) of P2X
10) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.13 Pain Relevance 0.18
The effects of the MTS reagents on the P2X2 receptor mutants were the same following washout of the compounds showing that they irreversibly modified the receptors.
Regulation (effects) of P2X2
11) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2459275 Disease Relevance 0 Pain Relevance 0.12
Besides P2X3, the regulation of other P2X receptors also changes following nerve injury.
Regulation (regulation) of P2X in nerve associated with nervous system injury
12) Confidence 0.25 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.93 Pain Relevance 0.46
GABAA receptors mediated modulation of expression of both P2X2 and P2X4 receptors, which may play an important role in the regulation of seizure activity in the gerbil hippocampus [139].
Regulation (modulation) of P2X2 in hippocampus associated with convulsion and hippocampus
13) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.79 Pain Relevance 0.45
Evidence for a control of P2X receptor channel function by PKC-mediated phosphorylation
Regulation (control) of P2X associated with kinase c
14) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0.31 Pain Relevance 0.22
Accordingly, all current recordings were done within a time window of 10 min after PMA application to prevent any contribution of receptor internalization to the PMA effect on P2X receptor-dependent currents.
Regulation (effect) of P2X
15) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.06
However, taking into consideration lipid binding to recombinant C-terminal P2X2 channel constructs, they proposed that PI(3)P and PI(3,5)P2, rather than PIP2 or PIP3, are the main regulators of homomeric P2X2 function.
Regulation (regulators) of P2X2
16) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.06 Pain Relevance 0.03
As an example, we have used suramin, PPADS, and reactive blue 2 to study the participation of P2Y1, P2Y2, and P2X2 receptors in neuronal differentiation of P19 EC cells [38].
Regulation (participation) of P2X2 in P19 associated with embryonal carcinoma
17) Confidence 0.13 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.15 Pain Relevance 0.21
The effect of A-317491 (5-([(3-Phenoxybenzyl)[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl)-1,2,4-benzenetricarboxylic acid), a recently described selective P2X3 and P2X(2/3) receptor antagonist, on inflammatory mechanical hyperalgesia was examined.
Spec (examined) Regulation (effect) of P2X associated with hyperalgesia, inflammation and antagonist
18) Confidence 0.13 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15507220 Disease Relevance 0.52 Pain Relevance 0.55
Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors

Background

Regulation (regulation) of P2X2 in nociceptors associated with nociceptor
19) Confidence 0.09 Published 2009 Journal Mol Pain Section Title Doc Link PMC2734547 Disease Relevance 0.50 Pain Relevance 0.38
While the homomeric P2X3 receptor is sensitive to changes in PIP2 levels only, the P2X2/3 heteromeric receptor is sensitive to changes in both PIP2 and PIP3 levels.
Regulation (sensitive) of P2X2
20) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.64 Pain Relevance 0.46

General Comments

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