INT92876

Context Info Confidence 0.45 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.71 Pain Relevance 0

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)

PDE5A (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 2 39.28 ischemia 2 25.00

Disease Link Frequency Relevance Heat Coronary Heart Disease 4 97.92 Cardiovascular Disease 2 86.92 Reprotox - General 2 6 85.08 Myocardial Infarction 6 41.52 Cv General 3 Under Development 2 39.28 Stroke 2 37.92 Heart Disease 2 25.00 Infarction 2 25.00 Cv Unclassified Under Development 2 25.00 Stress 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sildenafil is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5), the enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP).

Regulation (responsible) of Protein_catabolism (degradation) of PDE5

1) Confidence 0.45 Published 2000 Journal Am. J. Med. Section Abstract Doc Link 11137498 Disease Relevance 0.35 Pain Relevance 0

Sildenafil is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5), the enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP).

Regulation (responsible) of Protein_catabolism (degradation) of phosphodiesterase type 5

2) Confidence 0.39 Published 2000 Journal Am. J. Med. Section Abstract Doc Link 11137498 Disease Relevance 0.35 Pain Relevance 0

General Comments

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