INT93056

Context Info Confidence 0.44 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.42 Pain Relevance 0.34

cellular_component (C2)

Anatomy Link Frequency DRGs 1 dorsal horn 1 C2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dorsal horn 1 100.00 headache 2 98.02 midbrain 1 82.00 parabrachial 1 77.60 spinal dorsal horn 1 75.00 medulla 1 75.00 Periaqueductal grey 1 73.52 Facet joint 2 50.00 Pain 4 10.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 15 100.00 Disease 31 99.32 Headache 2 98.02 Cardiovascular Disease 43 81.52 Urological Neuroanatomy 1 73.52 Edema 5 5.00 Obesity 3 5.00 Thrombosis 2 5.00 Telangiectasia 2 5.00 Venous Stasis Ulcers 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To examine the ascending projections from the headache-related trigeminocervical complex in rats, biotinylated dextran amine (BDA) was injected into the ventrolateral dorsal horn of segments C1 and C2, a region previously demonstrated to receive input from sensory nerves in cranial blood vessels.

Regulation (ventrolateral) of C2 in dorsal horn associated with dorsal horn and headache

1) Confidence 0.44 Published 2009 Journal Cephalalgia Section Abstract Doc Link 19250290 Disease Relevance 0.17 Pain Relevance 0.34

The number of the labeled neurons after sympathectomy was not significantly different in the C1, C2, and C3 DRGs in the C1-C2 group, in the C3 and C4 DRGs in the C3-C4 group, and in the C5 and C6 DRGs in the C5-C6 group from that in the groups without sympathectomy.

Regulation (different) of C2 in DRGs

2) Confidence 0.31 Published 2001 Journal Spine Section Body Doc Link 11154533 Disease Relevance 0 Pain Relevance 0

Patients affected by simple VV (C2) were first affected at 35.8 years compared to 30.7 years for patients with CVI (C3 to C5&C6).

Regulation (affected) of C2 associated with increased venous pressure under development

3) Confidence 0.03 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 1.25 Pain Relevance 0

General Comments

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