INT93182

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.96
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
glial cell 5
peripheral nervous system 1
mere 1
Gdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 123 100.00 Very High Very High Very High
Peripheral nervous system 3 98.96 Very High Very High Very High
nociceptor 62 93.76 High High
dorsal root ganglion 2 93.76 High High
unmyelinated 20 93.44 High High
diabetic neuropathy 2 89.52 High High
alcohol 8 85.52 High High
agonist 52 84.24 Quite High
Spinal cord 16 77.44 Quite High
Calcitonin gene-related peptide 67 69.84 Quite High
Disease Link Frequency Relevance Heat
Toxicity 32 99.36 Very High Very High Very High
Parkinson's Disease 164 99.18 Very High Very High Very High
Disease 36 94.84 High High
Ganglion Cysts 200 92.80 High High
Diabetes Mellitus 14 92.04 High High
Diabetic Neuropathy 2 89.52 High High
Hyperglycemia 2 81.36 Quite High
Nociception 4 75.00 Quite High
Parkinsonian Disorders 28 62.00 Quite High
Death 29 8.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tyrosine hydroxylase (TH), glial cell line-derived neurotrophic factor (GDNF)
                   and glial fibrillary acidic protein (GFAP) immunostaining
GDNF Binding (line) of in glial cell
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.04
Interestingly,
               GDNF and TGF-? 
GDNF Binding (Interestingly) of
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.06 Pain Relevance 0.04
Perhaps it is not a mere coincidence that the
               same receptor positively regulates the formation of GDNF and TGF-?. 
GDNF Binding (formation) of in mere
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.08
For example, the orally
               active compound, PYM50028, which elevates striatal levels of GDNF, is protective
               against MPTP toxicity in mice [47], and induction of GDNF is associated with the
               neurorescue action of rasagilin, a drug of current use in the treatment of
               Parkinson's disease [48], [49]. 
GDNF Binding (associated) of associated with parkinson's disease, toxicity and disease
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.67 Pain Relevance 0.13
The peptidergic population responds to nerve growth factor (NGF), while the nonpeptidergic DRG neurons postnatally switch their dependency from NGF to glial cell line-derived neurotrophic factor (GDNF).
GDNF Binding (switch) of in glial cell associated with nerve growth factor
5) Confidence 0.32 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11161605 Disease Relevance 0.49 Pain Relevance 0.48
The peptidergic population responds to nerve growth factor (NGF), while the nonpeptidergic DRG neurons postnatally switch their dependency from NGF to glial cell line-derived neurotrophic factor (GDNF).
neurotrophic factor Binding (switch) of in glial cell associated with nerve growth factor
6) Confidence 0.32 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11161605 Disease Relevance 0.49 Pain Relevance 0.48
Fig. 1Cell surface receptors for GDNF family ligands and neurotrophins in the peripheral nervous system. a The GDNF family ligands, viz. glial cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN) and artemin (ARTN), bind to the alpha receptor subunits GFRalpha1, GFRalpha2 and GFRalpha3, respectively.
GDNF Binding (ligands) of in peripheral nervous system associated with peripheral nervous system
7) Confidence 0.26 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.05
Cloning of the genes coding for glial cell-line-derived neurotrophic factor (GDNF), neurturin, artemin and persephin and their cell surface receptors GFRalpha1 to GFRalpha4 acting in a complex with the receptor tyrosine kinase ret (“rearranged during transfection” proto-oncogene; for a review, see Airaksinen and Saarma 2002; Fig. 1) has allowed the analysis of their in vivo function in mutant mice.
cell-line-derived neurotrophic factor Binding (coding) of in glial cell
8) Confidence 0.23 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.08
Cloning of the genes coding for glial cell-line-derived neurotrophic factor (GDNF), neurturin, artemin and persephin and their cell surface receptors GFRalpha1 to GFRalpha4 acting in a complex with the receptor tyrosine kinase ret (“rearranged during transfection” proto-oncogene; for a review, see Airaksinen and Saarma 2002; Fig. 1) has allowed the analysis of their in vivo function in mutant mice.
GDNF Binding (coding) of in glial cell
9) Confidence 0.23 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.08
GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family of ligands, artemin.
neurotrophic factor Binding (binds) of
10) Confidence 0.00 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422460 Disease Relevance 0.25 Pain Relevance 0.17

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