INT9330

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Context Info
Confidence 0.31
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.99
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp1) extracellular region (Igfbp1)
Anatomy Link Frequency
plasma 2
liver 2
blood 1
Igfbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 45 100.00 Very High Very High Very High
cytokine 3 99.34 Very High Very High Very High
Inflammation 42 99.22 Very High Very High Very High
anesthesia 28 92.24 High High
opiate 16 77.84 Quite High
Morphine 8 74.96 Quite High
corticosteroid 6 69.36 Quite High
Action potential 6 31.44 Quite Low
analgesia 10 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 99.22 Very High Very High Very High
Sepsis 30 96.32 Very High Very High Very High
Bronchopulmonary Dysplasia 10 95.20 Very High Very High Very High
Hyperglycemia 3 93.20 High High
Hyperinsulinism 2 91.28 High High
Critical Illness 78 86.48 High High
Muscle Weakness 8 83.08 Quite High
Muscle Disease 82 69.76 Quite High
Fatigue 2 69.44 Quite High
Body Weight 6 66.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both MOR and M6G increased the concentration of IGF binding protein-1 (IGFBP-1) in plasma and liver 2 h after injection.
IGF binding protein-1 Binding (concentration) of in liver
1) Confidence 0.31 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8724426 Disease Relevance 0 Pain Relevance 0.43
Both MOR and M6G increased the concentration of IGF binding protein-1 (IGFBP-1) in plasma and liver 2 h after injection.
IGFBP-1 Binding (concentration) of in liver
2) Confidence 0.31 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8724426 Disease Relevance 0 Pain Relevance 0.43
Serum immunoreactive IGFBP-2 was unchanged among the groups, indicating that IGFBP-1 accounted for the increase in doublet intensity.
IGFBP-1 Binding (accounted) of
3) Confidence 0.29 Published 1992 Journal Pediatr. Res. Section Abstract Doc Link 1408464 Disease Relevance 0.24 Pain Relevance 0.17
Inflammatory cytokines (IL-6 and IL-10), IGF-I and its binding proteins (IGFBP-I, IGFBP-III) were analysed from blood samples, drawn between days 3 and 7 as well as between days 8 and 10 after ICU admission.
IGFBP-I Spec (analysed) Binding (binding) of in blood associated with inflammation and cytokine
4) Confidence 0.29 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 0.92 Pain Relevance 0.14
Impairment of IGF-I may be due to inflammation-induced upregulation of high-affinity IGFBP-1 which prevents IGF-I receptor binding [32].
IGFBP-1 Binding (binding) of associated with inflammation
5) Confidence 0.27 Published 2010 Journal Crit Care Section Body Doc Link PMC2911767 Disease Relevance 1.14 Pain Relevance 0.29
The smaller IGFBPs (IGFBP-1, -2, -4, -6) form binary complexes with IGF-1 and do not bind to ALS.
IGFBP-1 Binding (bind) of
6) Confidence 0.17 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.21 Pain Relevance 0
We suggest different phases of the interaction between dexamethasone and the IGF/IGFBP-1 axis:
IGFBP-1 Binding (interaction) of associated with dexamethasone
7) Confidence 0.14 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.47 Pain Relevance 0.18
Both MOR and M6G increased the concentration of IGF binding protein-1 (IGFBP-1) in plasma and liver 2 h after injection.
IGFBP-1 Binding (concentration) of in plasma
8) Confidence 0.11 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8724426 Disease Relevance 0 Pain Relevance 0.43
Both MOR and M6G increased the concentration of IGF binding protein-1 (IGFBP-1) in plasma and liver 2 h after injection.
IGF binding protein-1 Binding (concentration) of in plasma
9) Confidence 0.11 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8724426 Disease Relevance 0 Pain Relevance 0.43

General Comments

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