INT93356

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 20.61
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
4T1 8
ND3 4
liver 2
MEF 2
skin 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1 89.68 High High
Inflammation 86 82.36 Quite High
Enkephalin 2 78.72 Quite High
cytokine 77 77.72 Quite High
Opioid 2 77.32 Quite High
Hippocampus 3 56.24 Quite High
Bile 12 50.00 Quite Low
cINOD 17 43.00 Quite Low
chemokine 16 36.96 Quite Low
alcohol 22 35.04 Quite Low
Disease Link Frequency Relevance Heat
Liver Cancer 72 100.00 Very High Very High Very High
Cancer 1416 99.98 Very High Very High Very High
Apoptosis 467 99.82 Very High Very High Very High
Hepatocellular Cancer 275 99.78 Very High Very High Very High
Drug Induced Neurotoxicity 4 99.48 Very High Very High Very High
Hodgkin's Disease 66 99.28 Very High Very High Very High
Skin Cancer 31 98.92 Very High Very High Very High
Disease 78 97.28 Very High Very High Very High
Death 67 96.12 Very High Very High Very High
Klatskin's Tumor 28 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the effects of Hr are mediated through decreased expression and activity of p53, the effects of Hr on apoptosis were examined in mouse embryonic fibroblast (MEF) cell lines derived from p53 knock out and wild-type mice.
Spec (whether) Negative_regulation (decreased) of Gene_expression (expression) of p53 in MEF associated with targeted disruption and apoptosis
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.74 Pain Relevance 0
MYC-induced HCC exhibited reduced p53 protein expression and transcriptional activity.
Negative_regulation (reduced) of Gene_expression (expression) of p53 associated with hepatocellular cancer
2) Confidence 0.44 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.82 Pain Relevance 0
Conversely, MYC-induced adult HCCs frequently exhibited reduced or no expression of p53 downstream targets.
Neg (no) Negative_regulation (reduced) of Neg (no) Gene_expression (expression) of p53
3) Confidence 0.44 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.65 Pain Relevance 0
Conversely, tumors in adult mice frequently exhibited reduced levels of p53 protein expression (Figure 10A and unpublished data).
Negative_regulation (reduced) of Gene_expression (expression) of p53 associated with cancer
4) Confidence 0.44 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.68 Pain Relevance 0
Not all tumors exhibited reduced p53 expression.
Negative_regulation (reduced) of Gene_expression (expression) of p53 associated with cancer
5) Confidence 0.44 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.64 Pain Relevance 0
In addition, since the tumor suppressor p53 has been implicated in the neurotoxicity of METH, this study also examined the levels of p53 mRNA and protein affected by METH and DADLE.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (levels) of p53 mRNA associated with drug induced neurotoxicity and cancer
6) Confidence 0.40 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.37 Pain Relevance 0.38
We assessed the expression of p53 and Her2 in both original tumor tissues and cell lines.
Negative_regulation (assessed) of Gene_expression (expression) of p53 associated with cancer
7) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.81 Pain Relevance 0
The mechanism appears to involve blunting p53 mediated apoptosis by down-regulating p53 expression.
Negative_regulation (regulating) of Gene_expression (expression) of p53 associated with apoptosis
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.54 Pain Relevance 0
The reduced p53 expression was confirmed by western blotting and real-time PCR analysis (supplementary Figure B is available at Carcinogenesis Online).
Negative_regulation (reduced) of Gene_expression (expression) of p53
9) Confidence 0.34 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.76 Pain Relevance 0
We assessed the expression of p53, cyclin D1 and survivin, to compare the differences in molecular changes associated with the prognosis between BDC and GB cancer.
Negative_regulation (assessed) of Gene_expression (expression) of p53 associated with klatskin's tumor and cancer
10) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 2.16 Pain Relevance 0
Notably, a tumor that exhibited high p53 protein levels, tumor 2264, exhibited a loss in expression of p53 target genes.
Negative_regulation (loss) of Gene_expression (expression) of p53 associated with cancer
11) Confidence 0.32 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.73 Pain Relevance 0
To evaluate loss of heterozygosity of liver tumors derived from mice heterozygous for p53 deletion, PCR analysis was performed as previously described (Timme and Thompson 1994).


Negative_regulation (loss) of Gene_expression (deletion) of p53 in liver associated with liver cancer
12) Confidence 0.32 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.42 Pain Relevance 0
Not all tumors exhibited reduced p53 expression.
Negative_regulation (exhibited) of Gene_expression (expression) of p53 associated with cancer
13) Confidence 0.32 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.64 Pain Relevance 0
In this study it is reported that the rate of p53 expression is small; therefore abnormal p53 protein expression may not be effective in the blockage of apoptosis mediated deaths of HRS cells [4].
Negative_regulation (abnormal) of Gene_expression (expression) of p53 associated with apoptosis
14) Confidence 0.30 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.69 Pain Relevance 0
In our study, p53 expression was detected in 26 (48%) of the 54 cases, but no association was determined with the histological subtype, the stage, age and survival.
Negative_regulation (detected) of Gene_expression (expression) of p53
15) Confidence 0.30 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.65 Pain Relevance 0
They have detected p53 expression more frequently in stage I, but in a lesser frequency in the advanced stages such as stage III and IV.
Negative_regulation (detected) of Gene_expression (expression) of p53
16) Confidence 0.30 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853498 Disease Relevance 0.76 Pain Relevance 0
Amplified products of P53short, P53long, ND3, and SRY loci were run on a gel: 5 ?
Negative_regulation (Amplified) of Gene_expression (products) of P53long in ND3
17) Confidence 0.27 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2266725 Disease Relevance 0 Pain Relevance 0
Amplified products of P53short, P53long, ND3, and SRY loci were run on a gel: 5 ?
Negative_regulation (Amplified) of Gene_expression (products) of P53short in ND3
18) Confidence 0.27 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2266725 Disease Relevance 0 Pain Relevance 0
Studying cells at different phases of transformation, we could show that an early event during transformation was the loss of expression of the CDKN2A locus, followed by inactivation of p53 and overexpression of c-myc.
Negative_regulation (loss) of Gene_expression (overexpression) of p53
19) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.60 Pain Relevance 0
Thus, it is likely that the inactivation of p53 function by HPV16 E6 oncoprotein might be responsible for cyclin B1 overexpression in skin.
Negative_regulation (inactivation) of Gene_expression (function) of p53 in skin
20) Confidence 0.15 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.45 Pain Relevance 0

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