INT93359

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 90
Total Number 91
Disease Relevance 69.77
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Trp53) mitochondrion (Trp53) endoplasmic reticulum (Trp53)
enzyme binding (Trp53) protein complex assembly (Trp53) DNA binding (Trp53)
Anatomy Link Frequency
brain 2
fibroblast 2
nucleus 2
hepatocytes 2
neuronal 2
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 8 99.40 Very High Very High Very High
Inflammation 195 98.94 Very High Very High Very High
qutenza 12 98.72 Very High Very High Very High
narcan 10 98.60 Very High Very High Very High
Hippocampus 49 98.56 Very High Very High Very High
Morphine 36 98.40 Very High Very High Very High
Antinociceptive 4 96.20 Very High Very High Very High
tolerance 14 95.56 Very High Very High Very High
Spinal cord 4 94.80 High High
opioid receptor 4 91.96 High High
Disease Link Frequency Relevance Heat
Cancer 3341 100.00 Very High Very High Very High
Cytomegalovirus Infection 40 100.00 Very High Very High Very High
Shock 32 100.00 Very High Very High Very High
Stress 362 99.98 Very High Very High Very High
Dna Damage 13 99.98 Very High Very High Very High
Apoptosis 1677 99.88 Very High Very High Very High
Glioma 728 99.84 Very High Very High Very High
Disease 798 99.66 Very High Very High Very High
Solid Tumor 55 99.60 Very High Very High Very High
Dilated Cardiomyopathy 1 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We must also take into consideration that activation of p53 may lead to the emergence of treatment resistant brain tumor cells that express mutant p53 or that have completely lost p53.
Positive_regulation (activation) of p53 in brain associated with brain tumor
1) Confidence 0.70 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.65 Pain Relevance 0.05
Whereas activation of p53 traditionally has been viewed as the main avenue, the potential medical applications of inhibiting p53 should also be realized.
Positive_regulation (activation) of p53
2) Confidence 0.70 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.40 Pain Relevance 0.08
Moreover, persistent activation of p53 in nearby residing normal neural stem cells could have adverse negative sideeffects such as stem cell depletion and premature organ aging [58, 159].
Positive_regulation (activation) of p53 in neural associated with aging
3) Confidence 0.70 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.48 Pain Relevance 0.07
Activation of endogenous wild-type p53 with small molecules, reactivation of mutant p53, or transfer of the p53 gene should therefore be considered [152].
Positive_regulation (Activation) of p53
4) Confidence 0.70 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.07 Pain Relevance 0
DADLE blocked both the increase of p53 mRNA and the decrease of p53 protein caused by METH.
Positive_regulation (increase) of p53 mRNA
5) Confidence 0.66 Published 2001 Journal Synapse Section Abstract Doc Link 11169780 Disease Relevance 0.18 Pain Relevance 0.22
Instead, morphine caused an NH(2)-terminal phosphorylation of p53 at Ser(9) and/or Ser(15) and a stabilization of p53 in MCF-7 cells that express wild-type p53. p53 phosphorylation was not antagonized by Nx and resulted in an increase of p53-dependent proteins including p21, Bax, and the death receptor Fas.
Positive_regulation (stabilization) of p53 in MCF-7 associated with narcan, death and morphine
6) Confidence 0.63 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 1.07 Pain Relevance 1.28
Our results suggest that morphine, alone or in combination with Nx, may reduce the growth of certain tumors, apparently in part through activation of p53.
Positive_regulation (activation) of p53 associated with cancer, narcan and morphine
7) Confidence 0.63 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12702572 Disease Relevance 0.63 Pain Relevance 0.72
Radiation is a potent inducer of P53 activation in response to double-strand DNA breaks [19].
Positive_regulation (activation) of P53
8) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.85 Pain Relevance 0
Western blotting for P53, P21 and P16 proteins revealed a rapid enhancement of P53 protein followed by an increased in P21 levels, while P16 levels remained unchanged (Figure 7b).
Positive_regulation (enhancement) of P53
9) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.59 Pain Relevance 0
We found that MYC activation was associated with an increase in p53 protein levels in adult hepatocytes, as measured by Western analysis (Figure 10A).
Positive_regulation (increase) of p53 in hepatocytes
10) Confidence 0.52 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.63 Pain Relevance 0
In contrast, tumors arising in neonatal mice expressed p53 protein and exhibited the induction of p53 target genes (Figure 10B and 10C).
Positive_regulation (induction) of p53 associated with cancer
11) Confidence 0.52 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.74 Pain Relevance 0
In adult hepatocytes, MYC activation failed to induce cell division, which was at least in part mediated through the activation of p53.
Positive_regulation (activation) of p53 in hepatocytes
12) Confidence 0.52 Published 2004 Journal PLoS Biology Section Abstract Doc Link PMC519000 Disease Relevance 0.54 Pain Relevance 0
Therefore, targeting pluripotency-associated molecules such as Myc and Sox2, combined with reactivation of p53, specifically in brain tumor stem cell populations could become one approach to effectively reduce tumor growth.
Positive_regulation (reactivation) of p53 in stem cell associated with cancer and brain tumor
13) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.89 Pain Relevance 0
Activation of endogenous wild-type p53 with small molecules, reactivation of mutant p53, or transfer of the p53 gene should therefore be considered [152].
Positive_regulation (Activation) of p53
14) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.14 Pain Relevance 0
Perhaps the reactivation of p53 specifically in brain tumor stem cells could induce permanent differentiation or apoptosis followed by tumor regression?
Positive_regulation (reactivation) of p53 in brain associated with cancer, apoptosis and brain tumor
15) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.56 Pain Relevance 0
While approximately half of all human tumors contain a mutation or deletion of TP53, the rest of the tumors often have inactivation of p53 through other mechanisms including viral infection, loss of ARF, or overexpression of MDM2 [21].
Positive_regulation (inactivation) of p53 associated with cancer and viral infection
16) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.29 Pain Relevance 0
Whereas activation of p53 traditionally has been viewed as the main avenue, the potential medical applications of inhibiting p53 should also be realized.
Positive_regulation (activation) of p53
17) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.42 Pain Relevance 0.09
Activation of endogenous wild-type p53 with small molecules, reactivation of mutant p53, or transfer of the p53 gene should therefore be considered [152].
Positive_regulation (Activation) of p53
18) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.15 Pain Relevance 0
Depleting cells of ribosomes by blocking production of ribosomal proteins was shown to induce p53-dependent inhibition of cell proliferation and morphological differentiation of glioma cells in vitro [147].
Positive_regulation (induce) of p53 associated with glioma
19) Confidence 0.50 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.34 Pain Relevance 0
ET-1 at 10 nM induced p38, Akt, p44/42, and SAP/JNK phosphorylation in a time-ordered manner.
Positive_regulation (induced) of p44
20) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.05 Pain Relevance 0

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