INT93506

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.61
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Anatomy Link Frequency
melanocytes 2
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 12 100.00 Very High Very High Very High
Analgesic 3 95.76 Very High Very High Very High
melanocortin 1 receptor 7 90.72 High High
Disease Link Frequency Relevance Heat
Experimental Melanoma 6 98.60 Very High Very High Very High
Myocardial Infarction 3 91.12 High High
Stroke 3 90.56 High High
Cancer 3 88.76 High High
Skin Cancer 6 85.32 High High
Pigment Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of tyrosinase expression by acetylsalicylic acid in murine B16 melanoma.
Negative_regulation (Down-regulation) of Gene_expression (expression) of tyrosinase associated with aspirin and experimental melanoma
1) Confidence 0.57 Published 2008 Journal Biol. Pharm. Bull. Section Title Doc Link 18175938 Disease Relevance 0.60 Pain Relevance 0.29
Therefore, the depigmenting effect of ASA might be due to inhibition of tyrosinase expression or enhancement of tyrosinase degradation.
Negative_regulation (inhibition) of Gene_expression (expression) of tyrosinase
2) Confidence 0.57 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18175938 Disease Relevance 0.49 Pain Relevance 0.15
ASA inhibited tyrosinase expression in a dose-dependent manner.
Negative_regulation (inhibited) of Gene_expression (expression) of tyrosinase
3) Confidence 0.42 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18175938 Disease Relevance 0.52 Pain Relevance 0.16
Mouse E(+)/E(+) melanocytes, but not e/e or E(so)/E(so) melanocytes, respond to agouti signaling protein with decreased basal tyrosinase activity, and reduction in levels of tyrosinase and tyrosinase-related proteins 1 and 2.
Negative_regulation (reduction) of Gene_expression (levels) of tyrosinase in melanocytes
4) Confidence 0.31 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.55

General Comments

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