INT93520

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.32
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCYAP1) extracellular region (ADCYAP1) cell-cell signaling (ADCYAP1)
Anatomy Link Frequency
nerve 1
pituitary 1
ADCYAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 15 94.00 High High
adenocard 3 81.68 Quite High
Neuropeptide 3 75.24 Quite High
antagonist 3 75.00 Quite High
Inflammation 1 41.80 Quite Low
Migraine 1 40.64 Quite Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 1 91.04 High High
Increased Venous Pressure Under Development 3 88.68 High High
Diabetes Mellitus 4 81.24 Quite High
Neuroblastoma 1 58.12 Quite High
Neurogenic Inflammation 1 41.80 Quite Low
Headache 1 40.64 Quite Low
Heart Rate Under Development 1 39.84 Quite Low
Disease 2 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease in neuronal nitric oxide synthase, vasoactive intestinal peptide, PACAP, and tyrosine hydroxylase immunopositive nerve fibers was observed in circular muscle layer while substance P immunoreactivity was increased.
Negative_regulation (decrease) of PACAP in nerve
1) Confidence 0.42 Published 2001 Journal Gastroenterology Section Body Doc Link 11487552 Disease Relevance 0.08 Pain Relevance 0
SB-(+)-273779 also did not inhibit forskolin and pituitary adenylate cyclase-activating polypeptide.
Negative_regulation (inhibit) of pituitary adenylate cyclase-activating polypeptide in pituitary
2) Confidence 0.29 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181905 Disease Relevance 0.24 Pain Relevance 0.42
Incubation of the cells with both PACAP and IBMX resulted in a reduction in uptake which was not significantly different from the uptake in the presence of either PACAP or IBMX alone suggesting IBMX, like PACAP, is inhibiting the NHE3-dependent component of Gly–Sar uptake.
Negative_regulation (inhibiting) of PACAP
3) Confidence 0.10 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2428106 Disease Relevance 0 Pain Relevance 0.11

General Comments

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