INT93578

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.97
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
HGF 4
endothelial cells 1
platelet 1
Hgf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 25 100.00 Very High Very High Very High
Neurotransmitter 2 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
Angina 1 97.76 Very High Very High Very High
Bile 53 91.40 High High
ischemia 20 82.04 Quite High
COX-2 inhibitor 3 79.16 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 55 100.00 Very High Very High Very High
Thrombosis 3 99.52 Very High Very High Very High
Cholestasis 33 98.38 Very High Very High Very High
Ulcers 21 98.08 Very High Very High Very High
Hypoxia 25 91.04 High High
Malignant Neoplastic Disease 4 84.32 Quite High
Peptic Ulcer 3 82.44 Quite High
Cv Unclassified Under Development 20 82.04 Quite High
Extrahepatic Cholestasis 17 78.96 Quite High
Apoptosis 16 72.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of this thrombus-associated HGF release, however, is unknown.
Localization (release) of HGF in HGF associated with thrombosis
1) Confidence 0.77 Published 2002 Journal Circulation Section Abstract Doc Link 12473563 Disease Relevance 0.37 Pain Relevance 0.10
We conclude that 1) neutralization of HGF and gastrin by their specificantibodies delays ulcer healing due fall in the microcirculation around the ulcer and a decrease in the COX-2 expression, 2) COX-2 derived prostaglandins may play an important role in acceleration of the ulcer healing by various growth factors including HGF and gastrin, 3) enhancement of the local pool for growth factors such as HGF and gastrin at the ulcer site could offer a new modality for treatment of gastric ulcer.
Localization (neutralization) of HGF in HGF associated with ulcers and peptic ulcer
2) Confidence 0.69 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11192947 Disease Relevance 1.17 Pain Relevance 0.04
Although the aim of this work was not the identification of the molecular effectors responsible for the angiogenic properties of EPC-CM, we have confirmed that EPC release key angiogenic molecules such as Angiogenin, HGF, IL-8, PDGF, SDF-1 and VEGF in culture.
Localization (release) of HGF in HGF
3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.23 Pain Relevance 0.03
Preclinical studies have described that EPC secretion of factors involved in the regulation of stem cell recruitment and in vascular growth and remodeling (such as SDF-1, VEGF, HGF and MMP-9) [5], [17] support the function of mature endothelial cells in vitro and tissue regeneration in a variety of animal models [21], [22].
Localization (secretion) of HGF in endothelial cells
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.07 Pain Relevance 0.04
However, during their intense proliferation in obstructive cholestasis, proliferating cholangiocytes acquire the phenotype of neuroendocrine cells and secrete different substances including neurotransmitters (serotonin) [137], neuropeptides (opioid peptides such as met-enkephalin) [138-141], hormones (prolactin) [142] and their receptors (estrogens) [11] and growth factors, (that is, insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), TGF?
Localization (secrete) of HGF in platelet associated with cholestasis, neurotransmitter, neuropeptide, enkephalin, opioid and serotonin
5) Confidence 0.20 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.94 Pain Relevance 0.62
Of course, besides VEGF, released angiogenic cytokines after MI include fibroblast growth factor (FGF), hepatocyte growth factor (HGF), and so on [28].
Localization (released) of HGF in HGF associated with myocardial infarction and cytokine
6) Confidence 0.15 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.18 Pain Relevance 0.21

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