INT93635

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.30
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
chromaffin cells 2
CAR 1
liver 1


Pain Term Frequency Confidence Heat
medulla 2 88.12 High High
Paracetamol 2 76.80 Quite High
Neuropeptide 6 75.00 Quite High
Neurotransmitter 2 75.00 Quite High
Serotonin 2 61.04 Quite High
Enkephalin 4 59.84 Quite High
substance P 2 56.40 Quite High
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Stroke 18 98.08 Very High Very High Very High
Injury 4 92.96 High High
Hyperlipoproteinemia Type Ii 2 83.48 Quite High
Atherosclerosis 106 77.56 Quite High
Cardiovascular Disease 22 76.16 Quite High
Nephrotoxicity 4 75.00 Quite High
Coronary Artery Disease 12 72.24 Quite High
Necrosis 3 46.64 Quite Low
Hypertension 28 37.68 Quite Low
Nicotine Addiction 4 28.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This stimulation was due to soluble factors released from the chromaffin cells under basal, unstimulated conditions and involved the increased expression of P450 enzymes, StAR and de novo protein synthesis.
Gene_expression (expression) of P450 enzymes in chromaffin cells
1) Confidence 0.75 Published 2000 Journal Endocr. Res. Section Abstract Doc Link 11196460 Disease Relevance 0 Pain Relevance 0.29
When the gene expression of the P450 enzymes synthesizing these epoxides were looked at, the data were found to be consistent with EET levels, indicating differences in the mediators other than EETs in the mechanism of the end organ injury.
Gene_expression (expression) of P450 enzymes associated with injury
2) Confidence 0.75 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 1.08 Pain Relevance 0
The nitric oxide (NO) donor, O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO in the liver and possibly other tissues.
Gene_expression (metabolized) of P450 enzymes in liver
3) Confidence 0.65 Published 2003 Journal Toxicology Section Abstract Doc Link 12832150 Disease Relevance 0.14 Pain Relevance 0.15
This stimulation was due to soluble factors released from the chromaffin cells under basal, unstimulated conditions and involved the increased expression of P450 enzymes, StAR and de novo protein synthesis.
Gene_expression (synthesis) of P450 enzymes in chromaffin cells
4) Confidence 0.58 Published 2000 Journal Endocr. Res. Section Abstract Doc Link 11196460 Disease Relevance 0 Pain Relevance 0.30
Other examples of cross-talks between RXR's partners include PPAR with COUP-TF [52], TR with LXR [53], TR with VDR [54], and multiple partners (CAR, PXR, LXR, FXR, and PPAR) on the expression of P450 enzymes [55].

3.2.

Gene_expression (expression) of P450 enzymes in CAR
5) Confidence 0.58 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
When the gene expression of the P450 enzymes synthesizing these epoxides were looked at, the data were found to be consistent with EET levels, indicating differences in the mediators other than EETs in the mechanism of the end organ injury.
Gene_expression (synthesizing) of P450 enzymes associated with injury
6) Confidence 0.58 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 1.08 Pain Relevance 0

General Comments

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