INT93635

Context Info Confidence 0.75 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 2.30 Pain Relevance 0.74

Anatomy Mention Frequency chromaffin cells 2 CAR 1 liver 1

Pain Term Frequency Confidence Heat medulla 2 88.12 Paracetamol 2 76.80 Neuropeptide 6 75.00 Neurotransmitter 2 75.00 Serotonin 2 61.04 Enkephalin 4 59.84 substance P 2 56.40 Inflammatory marker 2 5.00 Bioavailability 2 5.00 IPN 2 5.00

Disease Term Frequency Confidence Heat Stroke 18 98.08 Injury 4 92.96 Hyperlipoproteinemia Type Ii 2 83.48 Atherosclerosis 106 77.56 Cardiovascular Disease 22 76.16 Nephrotoxicity 4 75.00 Coronary Artery Disease 12 72.24 Necrosis 3 46.64 Hypertension 28 37.68 Nicotine Addiction 4 28.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This stimulation was due to soluble factors released from the chromaffin cells under basal, unstimulated conditions and involved the increased expression of P450 enzymes, StAR and de novo protein synthesis.

Gene_expression (expression) of P450 enzymes in chromaffin cells

1) Confidence 0.75 Published 2000 Journal Endocr. Res. Section Abstract Doc Link 11196460 Disease Relevance 0 Pain Relevance 0.29

When the gene expression of the P450 enzymes synthesizing these epoxides were looked at, the data were found to be consistent with EET levels, indicating differences in the mediators other than EETs in the mechanism of the end organ injury.

Gene_expression (expression) of P450 enzymes associated with injury

2) Confidence 0.75 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 1.08 Pain Relevance 0

The nitric oxide (NO) donor, O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), is metabolized by P450 enzymes to release NO in the liver and possibly other tissues.

Gene_expression (metabolized) of P450 enzymes in liver

3) Confidence 0.65 Published 2003 Journal Toxicology Section Abstract Doc Link 12832150 Disease Relevance 0.14 Pain Relevance 0.15

This stimulation was due to soluble factors released from the chromaffin cells under basal, unstimulated conditions and involved the increased expression of P450 enzymes, StAR and de novo protein synthesis.

Gene_expression (synthesis) of P450 enzymes in chromaffin cells

4) Confidence 0.58 Published 2000 Journal Endocr. Res. Section Abstract Doc Link 11196460 Disease Relevance 0 Pain Relevance 0.30

Other examples of cross-talks between RXR's partners include PPAR with COUP-TF [52], TR with LXR [53], TR with VDR [54], and multiple partners (CAR, PXR, LXR, FXR, and PPAR) on the expression of P450 enzymes [55]. 3.2.

Gene_expression (expression) of P450 enzymes in CAR

5) Confidence 0.58 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

When the gene expression of the P450 enzymes synthesizing these epoxides were looked at, the data were found to be consistent with EET levels, indicating differences in the mediators other than EETs in the mechanism of the end organ injury.

Gene_expression (synthesizing) of P450 enzymes associated with injury

6) Confidence 0.58 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 1.08 Pain Relevance 0

General Comments

This test has worked.