INT93676

Context Info Confidence 0.44 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.82

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 6 97.80 Morphine 2 97.12 opiate 1 90.76 cocaine 1 79.08 addiction 2 73.76

Disease Link Frequency Relevance Heat Drug Dependence 1 67.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cellular studies also highlight the relevance of other ATF/CREB family members which can affect Ca2+/cAMP response element (CRE) controlled transcription as well as other transcription factors which make the opioid induction longer lasting.

Regulation (affect) of Transcription (transcription) of ATF associated with opioid

1) Confidence 0.44 Published 2000 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 11200184 Disease Relevance 0.07 Pain Relevance 0.82

General Comments

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