INT93736

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Context Info
Confidence 0.02
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tgfb2) growth (Tgfb2) cell death (Tgfb2)
extracellular region (Tgfb2) cell morphogenesis (Tgfb2) extracellular matrix organization (Tgfb2)
Anatomy Link Frequency
cerebrospinal fluid 2
Tgfb2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Glutamate 2 99.70 Very High Very High Very High
Nerve growth factor 3 96.32 Very High Very High Very High
tetrodotoxin 1 95.12 Very High Very High Very High
Dopamine 6 94.40 High High
Substantia nigra 3 81.52 Quite High
Neurotransmitter 1 63.52 Quite High
cINOD 2 25.00 Low Low
aspirin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 1 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Apoptosis 4 95.40 Very High Very High Very High
Disease 11 93.56 High High
Parkinson's Disease 6 88.52 High High
Genetic Predisposition To Disease 1 25.00 Low Low
INFLAMMATION 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, application of glutamate significantly upregulated expression of TGF-beta2 and TGF-beta3 in the culture.
Positive_regulation (upregulated) of Gene_expression (expression) of TGF-beta2 associated with glutamate
1) Confidence 0.02 Published 2007 Journal Neuroscience Section Abstract Doc Link 17997227 Disease Relevance 0 Pain Relevance 0.22
We and other workers found markedly increased levels of cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-2, IL-4, IL-6, transforming growth factor (TFG)-alpha, TGF-beta1, and TGF-beta2, and decreased ones of neurotrophins, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), in the nigrostriatal DA regions and ventricular and lumbar cerebrospinal fluid of PD patients.
Positive_regulation (increased) of Gene_expression (levels) of TGF-beta2 in cerebrospinal fluid associated with necrosis, dopamine, nerve growth factor, cancer, disease and cytokine
2) Confidence 0.02 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 1.16 Pain Relevance 0.55

General Comments

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