INT93736

Context Info Confidence 0.02 First Reported 2000 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.16 Pain Relevance 0.77

extracellular space (Tgfb2) growth (Tgfb2) cell death (Tgfb2) extracellular region (Tgfb2) cell morphogenesis (Tgfb2) extracellular matrix organization (Tgfb2)

Anatomy Link Frequency cerebrospinal fluid 2 Tgfb2 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 8 100.00 Glutamate 2 99.70 Nerve growth factor 3 96.32 tetrodotoxin 1 95.12 Dopamine 6 94.40 Substantia nigra 3 81.52 Neurotransmitter 1 63.52 cINOD 2 25.00 aspirin 1 25.00

Disease Link Frequency Relevance Heat Cancer 1 100.00 Necrosis 1 100.00 Apoptosis 4 95.40 Disease 11 93.56 Parkinson's Disease 6 88.52 Genetic Predisposition To Disease 1 25.00 INFLAMMATION 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, application of glutamate significantly upregulated expression of TGF-beta2 and TGF-beta3 in the culture.

Positive_regulation (upregulated) of Gene_expression (expression) of TGF-beta2 associated with glutamate

1) Confidence 0.02 Published 2007 Journal Neuroscience Section Abstract Doc Link 17997227 Disease Relevance 0 Pain Relevance 0.22

We and other workers found markedly increased levels of cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-2, IL-4, IL-6, transforming growth factor (TFG)-alpha, TGF-beta1, and TGF-beta2, and decreased ones of neurotrophins, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), in the nigrostriatal DA regions and ventricular and lumbar cerebrospinal fluid of PD patients.

Positive_regulation (increased) of Gene_expression (levels) of TGF-beta2 in cerebrospinal fluid associated with necrosis, dopamine, nerve growth factor, cancer, disease and cytokine

2) Confidence 0.02 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 1.16 Pain Relevance 0.55

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