INT9374

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2010
Negated 6
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 6.04
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
Plasma 1
heart 1
neutrophils 1
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 18 99.60 Very High Very High Very High
tetrodotoxin 2 98.84 Very High Very High Very High
metalloproteinase 45 98.66 Very High Very High Very High
Inflammation 10 97.56 Very High Very High Very High
aspirin 16 97.48 Very High Very High Very High
cva 6 96.96 Very High Very High Very High
antagonist 3 92.56 High High
IPN 5 91.84 High High
Hippocampus 1 88.40 High High
Glutamate receptor 1 74.88 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 20 99.60 Very High Very High Very High
Coronary Artery Disease 8 99.20 Very High Very High Very High
Thrombosis 10 98.24 Very High Very High Very High
INFLAMMATION 17 97.56 Very High Very High Very High
Thrombosis Related Under Development 20 95.96 Very High Very High Very High
Middle Cerebral Artery Infarction 31 94.32 High High
Epilepsy 2 91.60 High High
Injury 12 90.88 High High
Blister 6 89.84 High High
Dyspnea 2 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of the identified tPA regulated genes in our study are associated with neutrophils.
Regulation (regulated) of tPA in neutrophils
1) Confidence 0.61 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.61 Pain Relevance 0.10
In addition, tetrodotoxin (3 microM), indomethacin (10 microM) and methylene blue (10 microM) had no effect on the TPA+-induced relaxation.
Neg (no) Regulation (effect) of TPA associated with tetrodotoxin
2) Confidence 0.24 Published 1997 Journal Life Sci. Section Abstract Doc Link 9365228 Disease Relevance 0 Pain Relevance 0.10
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (tPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of tissue type plasminogen activator associated with metalloproteinase
3) Confidence 0.17 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.05
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (tPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of tPA associated with metalloproteinase
4) Confidence 0.17 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.05
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (tPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of tPA associated with metalloproteinase
5) Confidence 0.17 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.05
We investigated whether the clinical evolution of symptoms in patients admitted with unstable angina is associated with changes in t-plasminogen activator antigen (t-PA) and von Willebrand (vW) factor levels.
Spec (whether) Regulation (changes) of t-PA associated with angina
6) Confidence 0.15 Published 1996 Journal Int. J. Cardiol. Section Abstract Doc Link 8792192 Disease Relevance 0.17 Pain Relevance 0.23
In normal rat slices barium augmented ionophoretically-induced rises in [K(+)](o) by approximately 120%, also in the presence of tetrodotoxin (TTX) (by approximately 150%), but did not significantly affect the TPA(+)-signal.
Neg (not) Regulation (affect) of TPA associated with tetrodotoxin
7) Confidence 0.15 Published 2002 Journal Brain Res. Section Abstract Doc Link 11755897 Disease Relevance 0.17 Pain Relevance 0.22
Results showed that the above hydrogel preparation process did not significantly alter the specific activity of the entrapped t-PA with regard to plasminogen activation and fibrin clot lysis ability.
Neg (not) Regulation (alter) of t-PA
8) Confidence 0.11 Published 2001 Journal J Control Release Section Abstract Doc Link 11451495 Disease Relevance 0.05 Pain Relevance 0.35
Neither drug had an effect on tissue-type plasminogen activator or plasminogen activator inhibitor type 1 (PAI-1).
Regulation (effect) of tissue-type plasminogen activator
9) Confidence 0.08 Published 1994 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 7915237 Disease Relevance 0.17 Pain Relevance 0.14
Effect of oral defibrotide on tissue-plasminogen activator and tissue-plasminogen activator inhibitor balance.
Regulation (Effect) of tissue-plasminogen activator
10) Confidence 0.08 Published 1992 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 1516602 Disease Relevance 0.31 Pain Relevance 0.06
Work by the same group targeting tissue-type plasminogen activator (tPA) also demonstrated effective prevention of thrombus formation [57].
Regulation (targeting) of tissue-type plasminogen activator associated with thrombosis
11) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.04 Pain Relevance 0.07
Work by the same group targeting tissue-type plasminogen activator (tPA) also demonstrated effective prevention of thrombus formation [57].
Regulation (targeting) of tPA associated with thrombosis
12) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.09 Pain Relevance 0.07
No change in tissue plasminogen activator activity was found.
Neg (No) Regulation (change) of tissue plasminogen activator
13) Confidence 0.04 Published 1992 Journal Thromb. Haemost. Section Abstract Doc Link 1412171 Disease Relevance 0.24 Pain Relevance 0.47
Plasma tissue-plasminogen activator antigen levels did not change in both two groups.
Neg (not) Regulation (change) of tissue-plasminogen activator in Plasma
14) Confidence 0.04 Published 1993 Journal Int. J. Cardiol. Section Abstract Doc Link 8225669 Disease Relevance 0.58 Pain Relevance 0.29
The long-term effects of metoprolol and epanolol on tissue-type plasminogen activator and plasminogen activator inhibitor 1 in patients with ischaemic heart disease.
Regulation (effects) of tissue-type plasminogen activator in heart associated with coronary artery disease
15) Confidence 0.04 Published 1994 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 7915237 Disease Relevance 0.18 Pain Relevance 0.13
Effect of oral defibrotide on tissue-plasminogen activator and tissue-plasminogen activator inhibitor balance.
Regulation (Effect) of tissue-plasminogen activator
16) Confidence 0.04 Published 1992 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 1516602 Disease Relevance 0.32 Pain Relevance 0.06
Tissue plasminogen activator (tPA) is a clot-specific fibrinolytic agent shown to be effective in decreasing postsurgical fibrin formation and enhancing filtration after trabeculectomy.
Regulation (effective) of Tissue plasminogen activator
17) Confidence 0.03 Published 1995 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 8590254 Disease Relevance 0.60 Pain Relevance 0
With particular reference to systemic effects of tissue-type plasminogen activator treatment on fibrinolysis, coagulation and complement pathways.
Regulation (effects) of tissue-type plasminogen activator
18) Confidence 0.03 Published 1993 Journal Dan Med Bull Section Title Doc Link 8222763 Disease Relevance 0.10 Pain Relevance 0
Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina.
Neg (not) Regulation (affect) of tissue plasminogen activator associated with angina
19) Confidence 0.03 Published 2005 Journal Eur. J. Endocrinol. Section Title Doc Link 15745938 Disease Relevance 0.19 Pain Relevance 0.10
Neither agent had a significant effect on bleeding time, von Willebrand factor or tissue plasminogen activator.
Regulation (effect) of tissue plasminogen activator
20) Confidence 0.02 Published 1998 Journal Acta Anaesthesiol Scand Section Body Doc Link 9773144 Disease Relevance 0 Pain Relevance 0

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