INT9382

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Context Info
Confidence 0.62
First Reported 1992
Last Reported 2010
Negated 13
Speculated 11
Reported most in Abstract
Documents 149
Total Number 160
Disease Relevance 53.99
Pain Relevance 77.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
nerves 6
external 5
nociceptors 5
neuronal 5
sensory neurons 4
TRPV1 (Homo sapiens)
TRPV1 - G315C (1)
Pain Link Frequency Relevance Heat
qutenza 955 100.00 Very High Very High Very High
Pain 855 100.00 Very High Very High Very High
antagonist 115 100.00 Very High Very High Very High
acular 63 100.00 Very High Very High Very High
Analgesic 39 100.00 Very High Very High Very High
IPN 33 100.00 Very High Very High Very High
Dismenorea 10 100.00 Very High Very High Very High
vanilloid receptor subtype 1 8 100.00 Very High Very High Very High
agonist 278 99.98 Very High Very High Very High
bradykinin 181 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 767 100.00 Very High Very High Very High
Injury 256 100.00 Very High Very High Very High
Nociception 171 100.00 Very High Very High Very High
Inflammatory Pain 74 100.00 Very High Very High Very High
Nervous System Injury 70 99.96 Very High Very High Very High
INFLAMMATION 394 99.84 Very High Very High Very High
Ganglion Cysts 293 99.76 Very High Very High Very High
Neuropathic Pain 187 99.70 Very High Very High Very High
Dyspepsia 15 99.56 Very High Very High Very High
Disease 126 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we investigated the effect of acute UV irradiation on TRPV1 expression in human skin and the changes in TRPV1 mRNA and protein in intrinsic ageing and photoageing using human sun-protected (upper inner arm) and sun-exposed (forearm) skin of young and elderly subjects.
Regulation (changes) of TRPV1 in forearm associated with aging
1) Confidence 0.62 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.19 Pain Relevance 0.09
Using site-directed mutagenesis, we identified Cys621 as the residue responsible for the extracellular modulation of TRPV1 by reducing agents.
Regulation (modulation) of TRPV1
2) Confidence 0.62 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16614139 Disease Relevance 0 Pain Relevance 0
Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system.
Regulation (Modulation) of TRPV1
3) Confidence 0.62 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16630609 Disease Relevance 0 Pain Relevance 0.42
Ab-156H antagonism of TRPV1 is not affected by the conformation of the capsaicin-binding pocket because it is equally potent at wild-type (capsaicin-sensitive) rat TRPV1 and its T550I mutant (capsaicin-insensitive).
Neg (not) Regulation (affected) of TRPV1 associated with qutenza
4) Confidence 0.62 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16844842 Disease Relevance 0.08 Pain Relevance 0.82
Abundant evidence has demonstrated that TRPV1 is also modulated by numerous inflammatory mediators, including growth factors, neurotransmitters, peptides or small proteins, lipids, chemokines and cytokines.
Regulation (modulated) of TRPV1 associated with chemokine, neurotransmitter, inflammatory mediators and cytokine
5) Confidence 0.62 Published 2007 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 17298290 Disease Relevance 0.93 Pain Relevance 0.91
Various second messenger systems regulate TRPV1 activity, predominantly by serine-threonine phosphorylation.
Regulation (regulate) of TRPV1
6) Confidence 0.62 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17217056 Disease Relevance 0.19 Pain Relevance 0.46
Lighting a backfire to quench the blaze: a combined drug approach targeting the vanilloid receptor TRPV1.
Regulation (targeting) of TRPV1 associated with qutenza
7) Confidence 0.62 Published 2007 Journal Mol. Interv. Section Title Doc Link 18199852 Disease Relevance 0.17 Pain Relevance 0.71
TRPV1 could be regulated by various physical and chemical modulators, as well as the chronic pain.
Regulation (regulated) of TRPV1 associated with lasting pain
8) Confidence 0.61 Published 2009 Journal Neurosci Bull Section Abstract Doc Link 19633705 Disease Relevance 0.69 Pain Relevance 0.43
Therefore, polyamine regulation of TRPV1 in these tissues may be relevant to a variety of physiological and pathophysiological states.
Regulation (regulation) of TRPV1
9) Confidence 0.61 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16431906 Disease Relevance 0.25 Pain Relevance 0.28
These data show that polyamines, by virtue of their cationic charge, can regulate the activity of TRPV1.
Regulation (regulate) of TRPV1
10) Confidence 0.61 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16431906 Disease Relevance 0.35 Pain Relevance 0.33
The G315C polymorphism affects the TRPV1 gene and alters its protein level.
Regulation (affects) of TRPV1
11) Confidence 0.60 Published 2010 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 19770677 Disease Relevance 0.07 Pain Relevance 0.17
Given the significant roles of VR1 and PKA in inflammatory pain hypersensitivity, VR1 phosphorylation at Ser116 by PKA may represent an important molecular mechanism involved in the regulation of VR1 function after tissue injury.
Regulation (regulation) of VR1 associated with injury, hypersensitivity, stimulus evoked pain and inflammatory pain
12) Confidence 0.58 Published 2002 Journal Neuron Section Abstract Doc Link 12194871 Disease Relevance 0.36 Pain Relevance 0.31
Dual regulation of TRPV1 by phosphoinositides.
Regulation (regulation) of TRPV1 associated with qutenza
13) Confidence 0.55 Published 2007 Journal J. Neurosci. Section Title Doc Link 17596456 Disease Relevance 0 Pain Relevance 0.81
These data strongly suggest that SSTRs modulate nociceptors through phasic and tonic regulation of peripheral TRPV1 receptors.
Regulation (regulation) of TRPV1 in nociceptors associated with nociceptor
14) Confidence 0.54 Published 2004 Journal Pain Section Abstract Doc Link 15288402 Disease Relevance 0 Pain Relevance 0.69
The present study provides several lines of evidence that an important mechanism underlying SSTR modulation of nociceptors is regulation of the transient receptor potential vanilloid 1 ion channel (TRPV1, formerly the VR1 receptor).
Regulation (regulation) of TRPV1 in nociceptors associated with nociceptor
15) Confidence 0.54 Published 2004 Journal Pain Section Abstract Doc Link 15288402 Disease Relevance 0.19 Pain Relevance 0.66
These data further support the supposition that modulation of VR1 is a mechanism for the BK-induced excitation of nociceptors and their sensitization to heat.
Regulation (modulation) of VR1 in nociceptors associated with nociceptor and bradykinin
16) Confidence 0.54 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12091579 Disease Relevance 0.26 Pain Relevance 1.14
Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons.
Regulation (affects) of TRPV1 in sensory neurons associated with qutenza
17) Confidence 0.54 Published 2008 Journal J. Neurooncol. Section Title Doc Link 18414789 Disease Relevance 0.27 Pain Relevance 0.49
Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain.
Regulation (modulating) of transient receptor potential vanilloid 1 receptor associated with inflammatory mediators, inflammation and neuropathic pain
18) Confidence 0.54 Published 2007 Journal Expert Opin. Ther. Targets Section Title Doc Link 17298290 Disease Relevance 1.20 Pain Relevance 1.34
However, this protein had no significant effect on VR1 channel activity in response to CAP.
Neg (no) Regulation (effect) of VR1 associated with qutenza
19) Confidence 0.52 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883036 Disease Relevance 0.10 Pain Relevance 0.29
Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current.
Regulation (sensitize) of vanilloid receptor associated with qutenza
20) Confidence 0.45 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16614139 Disease Relevance 0 Pain Relevance 0.10

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