INT93878

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.09
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lipc) extracellular space (Lipc) extracellular region (Lipc)
transferase activity, transferring acyl groups (Lipc) lipid metabolic process (Lipc)
Anatomy Link Frequency
blood 1
skin 1
Lipc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 1 95.60 Very High Very High Very High
opiate 1 64.40 Quite High
Spinal cord 1 25.00 Low Low
anesthesia 1 25.00 Low Low
Angina 4 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acid Base Imbalance 1 99.96 Very High Very High Very High
Coronary Artery Disease 177 99.84 Very High Very High Very High
Congenital Anomalies 9 99.56 Very High Very High Very High
Disorder Of Lipid Metabolism 74 99.12 Very High Very High Very High
Atherosclerosis 17 98.24 Very High Very High Very High
Convulsion 1 95.20 Very High Very High Very High
Vomiting 1 92.04 High High
Poisoning 6 88.64 High High
Conversion Disorder 1 87.24 High High
Disease 20 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, laboratory findings such as ECG abnormalities, metabolic acidosis, increased serum hepatic enzyme levels, and increased serum blood urea nitrogen and creatinine levels are also useful in obtaining the correct diagnosis.
Positive_regulation (increased) of serum hepatic enzyme in blood associated with congenital anomalies and acid base imbalance
1) Confidence 0.47 Published 2000 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 11215255 Disease Relevance 1.19 Pain Relevance 0.06
Thus, further studies on sequence variations of the LIPC gene in CAD patients are warranted, in particular looking at the possible influences on clinical outcomes.
Positive_regulation (variations) of LIPC gene associated with coronary artery disease
2) Confidence 0.41 Published 2003 Journal BMC Med Genet Section Body Doc Link PMC201027 Disease Relevance 0.75 Pain Relevance 0
Moennig et al. [26] sequenced the LIPC gene in patients with low HDL/high triglycerides and CAD, and their results suggested that mutations in LIPC may play a role in the pathogenesis of atherosclerosis.
Positive_regulation (sequenced) of LIPC gene associated with coronary artery disease, atherosclerosis and disorder of lipid metabolism
3) Confidence 0.41 Published 2003 Journal BMC Med Genet Section Body Doc Link PMC201027 Disease Relevance 0.86 Pain Relevance 0
Responses of hepatic glucose output (HGO) to noxious mechanical stimulation of different skin areas were investigated in anaesthetised rats with central nervous system intact or acutely spinalized at the thoracic 1-2 (T1-T2) level by focusing on the involvement of the sympathetic and parasympathetic nerves in the responses of HGO.
Spec (investigated) Positive_regulation (Responses) of hepatic glucose output in skin associated with central nervous system
4) Confidence 0.03 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12492135 Disease Relevance 0 Pain Relevance 0.05
Excess triglycerides in the LDL particle allows continued size reduction by hepatic triglyceride lipase, which may result in lipid-poor, thus, protein-rich LDL particles of relatively high density.53 In addition to the addition of triglycerides, it has been suggested that genetic factors and increased hepatic lipase and lipid transfer activities also contribute to LDL heterogenicity.
Positive_regulation (increased) of hepatic lipase
5) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2688162 Disease Relevance 0.29 Pain Relevance 0

General Comments

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