INT93885

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.40
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MKI67) nucleolus (MKI67) nucleus (MKI67)
intracellular (MKI67) cell cycle (MKI67) DNA metabolic process (MKI67)
MKI67 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 6 100.00 Very High Very High Very High
Dismenorea 1 87.36 High High
cva 1 83.52 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 66 100.00 Very High Very High Very High
Endometriosis (extended) 11 100.00 Very High Very High Very High
Fibrosis 6 100.00 Very High Very High Very High
Cancer 156 99.98 Very High Very High Very High
Pancreatic Ductal Carcinoma 34 98.24 Very High Very High Very High
Disease 18 97.12 Very High Very High Very High
Breast Cancer 127 89.60 High High
Genetic Translocation 1 87.44 High High
Dysmenorrhea 1 87.36 High High
Residual Neoplasm 3 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a cohort of 147 high risk women, we previously showed that cytomorphologic atypia in benign breast cells obtained by RPFNA is associated with increased Ki-67 expression [6].
Positive_regulation (increased) of Gene_expression (expression) of Ki-67
1) Confidence 0.60 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.39 Pain Relevance 0
We previously showed that Ki-67 expression is higher in specimens of benign breast cells exhibiting cytologic atypia that are obtained by random periareolar fine needle aspiration (RPFNA).
Positive_regulation (higher) of Gene_expression (expression) of Ki-67
2) Confidence 0.47 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC1929099 Disease Relevance 0.16 Pain Relevance 0
Ki-67 expression increased with cytologic abnormality (atypia versus no atypia; P ?
Positive_regulation (increased) of Gene_expression (expression) of Ki-67
3) Confidence 0.41 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC1929099 Disease Relevance 0.16 Pain Relevance 0
And the results in the present study indicated that the mucin phenotypes of the atypical MGH (PanIN-1B by PanIN system) had a diffusely positive reaction for both anti-MUC1 staining and anti-45M1 staining, and had a spasely positive reaction for anti-Ki-67 staining, and these findings resembled those of the pancreatic ductal carcinoma (PDC), except for the expression of p53 (MGH: negative, PDC: positive).
Positive_regulation (reaction) of Gene_expression (staining) of anti-Ki-67 associated with pancreatic ductal carcinoma and hyperplasia
4) Confidence 0.11 Published 2005 Journal J Carcinog Section Body Doc Link PMC1185555 Disease Relevance 1.10 Pain Relevance 0
Double immunostaining was planned later because of increased Ki67 staining observed in the control biopsy after RFITT.
Positive_regulation (increased) of Gene_expression (staining) of Ki67
5) Confidence 0.07 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2535598 Disease Relevance 0.52 Pain Relevance 0.04
Patients whose tumors overexpress Ki-67 in more than 50% of the cells are at high risk of developing recurrent disease [7].
Positive_regulation (overexpress) of Gene_expression (overexpress) of Ki-67 associated with cancer and disease
6) Confidence 0.05 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400674 Disease Relevance 0.58 Pain Relevance 0
Tamoxifen induced endometrial polyps, cystic hyperplasia, stromal fibrosis, and PR expression but not Ki-67 expression.
Positive_regulation (induced) of Gene_expression (expression) of Ki-67 associated with fibrosis, endometriosis (extended) and hyperplasia
7) Confidence 0.04 Published 2001 Journal Toxicol Pathol Section Abstract Doc Link 11215689 Disease Relevance 0.58 Pain Relevance 0.14
In our study Ki67 was overexpressed (50-80% positive cells) in 10 cases with no statistical difference between the carcinomatous and the sarcomatous areas.
Positive_regulation (overexpressed) of Neg (no) Gene_expression (overexpressed) of Ki67
8) Confidence 0.02 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.90 Pain Relevance 0

General Comments

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