INT94003

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(Generated page)
 
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|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2000
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2000|2000]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2001
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2001|2001]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
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style=filled,
 
style=filled,
 
fillcolor=yellow,
 
fillcolor=yellow,
URL=Regulation
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Regulation"
 
];
 
];
 
node2
 
node2
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style=filled,
 
style=filled,
 
fillcolor=yellow,
 
fillcolor=yellow,
URL=Positive_regulation
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Positive_regulation"
 
];
 
];
 
node3
 
node3
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fontcolor=white,
 
fontcolor=white,
 
label="Lox",
 
label="Lox",
URL="Lox"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:24914"
 
];
 
];
 
subgraph cluster_0 {
 
subgraph cluster_0 {
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{| cellspacing=5 cellpadding=2
 
{| cellspacing=5 cellpadding=2
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[extracellular space]] ([[Lox]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:extracellular space|extracellular space]] ([[G:24914|Lox]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[oxidoreductase activity]] ([[Lox]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:oxidoreductase activity|oxidoreductase activity]] ([[G:24914|Lox]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[extracellular region]] ([[Lox]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:extracellular region|extracellular region]] ([[G:24914|Lox]])
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[proteinaceous extracellular matrix]] ([[Lox]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:proteinaceous extracellular matrix|proteinaceous extracellular matrix]] ([[G:24914|Lox]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[nucleus]] ([[Lox]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:nucleus|nucleus]] ([[G:24914|Lox]])
 
|-
 
|-
 
|}
 
|}
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{| cellspacing=1 cellpadding=5 align=center
 
{| cellspacing=1 cellpadding=5 align=center
 
|-
 
|-
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Term
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Link
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cINOD]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:cINOD|cINOD]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.54
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.54
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[qutenza]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:qutenza|qutenza]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.36
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.36
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[addiction]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:addiction|addiction]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 84.56
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 84.56
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{| cellspacing=1 cellpadding=5 align=center
 
{| cellspacing=1 cellpadding=5 align=center
 
|-
 
|-
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Term
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Link
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Apoptosis]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Apoptosis|Apoptosis]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.16
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.16
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Cancer]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Cancer|Cancer]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.28
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.28
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[INFLAMMATION]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:INFLAMMATION|INFLAMMATION]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.42
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.42
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Colon Cancer]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Colon Cancer|Colon Cancer]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 96.20
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 96.20
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
|  <span style="color:#000080">'''Regulation'''</span> (<span style="color:#000080">dependent</span>) of <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induction</span>) of <span style="color:#800000">'''LOX'''</span> associated with <span style="color:#FF0000">'''inflammation'''</span>, <span style="color:#FF0000">'''cancer'''</span>, <span style="color:#FF0000">'''colon cancer'''</span>, <span style="color:#FF0000">'''cinod'''</span> and <span style="color:#FF0000">'''apoptosis'''</span>
+
[[E:Regulation|<span style="color:#000080">'''Regulation'''</span>]] (<span style="color:#000080">dependent</span>) of [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">induction</span>) of [[G:24914|<span style="color:#800000">'''LOX'''</span>]] associated with <span style="color:#FF0000">'''inflammation'''</span>, <span style="color:#FF0000">'''cancer'''</span>, <span style="color:#FF0000">'''colon cancer'''</span>, <span style="color:#FF0000">'''cinod'''</span> and <span style="color:#FF0000">'''apoptosis'''</span>
 
|-
 
|-
 
|}
 
|}
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.26
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.26
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2001
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2001|2001]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Cancer Res.|Cancer Res.]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Cancer Res.|Cancer Res.]]
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
|  Neg (unaffected) <span style="color:#000080">'''Regulation'''</span> (<span style="color:#000080">unaffected</span>) of <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">stimulated</span>) of <span style="color:#800000">'''H-oxidase'''</span>
+
|  Neg (unaffected) [[E:Regulation|<span style="color:#000080">'''Regulation'''</span>]] (<span style="color:#000080">unaffected</span>) of [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">stimulated</span>) of [[G:24914|<span style="color:#800000">'''H-oxidase'''</span>]]
 
|-
 
|-
 
|}
 
|}
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.03
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.03
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2000
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2000|2000]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Antioxid. Redox Signal.|Antioxid. Redox Signal.]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Antioxid. Redox Signal.|Antioxid. Redox Signal.]]

Latest revision as of 14:12, 20 September 2012

Context Info
Confidence 0.26
First Reported 2000
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.53
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lox) oxidoreductase activity (Lox) extracellular region (Lox)
proteinaceous extracellular matrix (Lox) nucleus (Lox)
Lox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 97.54 Very High Very High Very High
qutenza 2 97.36 Very High Very High Very High
addiction 1 84.56 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1 99.16 Very High Very High Very High
Cancer 3 98.28 Very High Very High Very High
INFLAMMATION 1 97.42 Very High Very High Very High
Colon Cancer 1 96.20 Very High Very High Very High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies indicate that 15-LOX-1 is down-regulated in colorectal cancer cells and that the ability of nonsteroidal anti-inflammatory drugs, a class of clinically active cancer chemopreventive agents, to induce apoptosis and growth inhibition in these cells was dependent on the induction of 15-LOX-1 and its metabolic product 13-S-hydroxyoctadecadienoic acid.
Regulation (dependent) of Positive_regulation (induction) of LOX associated with inflammation, cancer, colon cancer, cinod and apoptosis
1) Confidence 0.26 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11522616 Disease Relevance 0.53 Pain Relevance 0.10
Comparison of NAD(P)H-oxidase on the surface of viable cells with trans-membrane NADH-oxidoreductase, measured with WST-1 in the presence of 1-methoxy PMS, showed that cell-surface NAD(P)H-oxidase was differentially inhibited by the cell-impermeable thiol-blocking agent pCMBS, but was unaffected or stimulated by other thiol blocking agents.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (stimulated) of H-oxidase
2) Confidence 0.03 Published 2000 Journal Antioxid. Redox Signal. Section Abstract Doc Link 11229532 Disease Relevance 0 Pain Relevance 0.14

[edit] General Comments

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