INT94003

Context Info Confidence 0.26 First Reported 2000 Last Reported 2001 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.53 Pain Relevance 0.24

extracellular space (Lox) oxidoreductase activity (Lox) extracellular region (Lox) proteinaceous extracellular matrix (Lox) nucleus (Lox)

Lox (Rattus norvegicus)

Pain Link Frequency Relevance Heat cINOD 1 97.54 qutenza 2 97.36 addiction 1 84.56

Disease Link Frequency Relevance Heat Apoptosis 1 99.16 Cancer 3 98.28 INFLAMMATION 1 97.42 Colon Cancer 1 96.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recent studies indicate that 15-LOX-1 is down-regulated in colorectal cancer cells and that the ability of nonsteroidal anti-inflammatory drugs, a class of clinically active cancer chemopreventive agents, to induce apoptosis and growth inhibition in these cells was dependent on the induction of 15-LOX-1 and its metabolic product 13-S-hydroxyoctadecadienoic acid.

Regulation (dependent) of Positive_regulation (induction) of LOX associated with inflammation, cancer, colon cancer, cinod and apoptosis

1) Confidence 0.26 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11522616 Disease Relevance 0.53 Pain Relevance 0.10

Comparison of NAD(P)H-oxidase on the surface of viable cells with trans-membrane NADH-oxidoreductase, measured with WST-1 in the presence of 1-methoxy PMS, showed that cell-surface NAD(P)H-oxidase was differentially inhibited by the cell-impermeable thiol-blocking agent pCMBS, but was unaffected or stimulated by other thiol blocking agents.

Neg (unaffected) Regulation (unaffected) of Positive_regulation (stimulated) of H-oxidase

2) Confidence 0.03 Published 2000 Journal Antioxid. Redox Signal. Section Abstract Doc Link 11229532 Disease Relevance 0 Pain Relevance 0.14

General Comments

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