INT94088

Context Info Confidence 0.55 First Reported 2001 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.39 Pain Relevance 0.53

signal transduction (Pde6b)

Anatomy Link Frequency PMN 1 Pde6b (Mus musculus)

Pain Link Frequency Relevance Heat orphanin 8 96.76 Pain 1 94.80 opioid receptor 1 94.08 aspirin 4 75.00 Inflammation 1 38.72 Central nervous system 3 5.00 anesthesia 2 5.00 Buprenorphine 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Cytomegalovirus Infection 9 95.60 Pain 1 94.80 Infection 20 5.00 Viral Infection 7 5.00 Sprains And Strains 5 5.00 Death 3 5.00 Disease 3 5.00 Spontaneous Abortion 2 5.00 Ganglion Cysts 2 5.00 Cataract 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The following targeting sequence was used for the PDE6b shRNA construct: 5?

Transcription (used) of PDE6b

1) Confidence 0.55 Published 2008 Journal Developmental Dynamics Section Body Doc Link PMC2532702 Disease Relevance 0.29 Pain Relevance 0

Human PMN express mRNA for Noci-R, its nucleotide sequence determined, and specific binding with [(125)I]-labeled nociceptin gave an apparent K(d) approximately 1.5 nM for this PMN opioid receptor.

Transcription (express) of Noci-R in PMN associated with orphanin and opioid receptor

2) Confidence 0.04 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11238602 Disease Relevance 0.09 Pain Relevance 0.53

General Comments

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