INT94127

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 14.00
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
nerve 3
adipose tissue 1
astrocytes 1
heart 1
microglia 1
Il18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 30 100.00 Very High Very High Very High
Inflammation 27 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Neuritis 10 99.96 Very High Very High Very High
Dorsal horn 4 99.88 Very High Very High Very High
spinal dorsal horn 4 99.84 Very High Very High Very High
Angina 18 99.68 Very High Very High Very High
Brush evoked pain 12 98.40 Very High Very High Very High
Inflammatory response 3 97.68 Very High Very High Very High
depression 93 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 50 100.00 Very High Very High Very High
Heart Rate Under Development 7 100.00 Very High Very High Very High
Obesity 11 99.98 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.96 Very High Very High Very High
Cv General 3 Under Development 15 99.68 Very High Very High Very High
Pancreatic Cancer 41 99.66 Very High Very High Very High
Natriuresis 2 99.56 Very High Very High Very High
Disease 17 99.20 Very High Very High Very High
Demyelinating Disease 5 99.08 Very High Very High Very High
Disease Progression 2 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-18 is induced in acute inflammatory demyelinating polyneuropathy.
Positive_regulation (induced) of Interleukin-18 associated with neuropathy, inflammation and demyelinating disease
1) Confidence 0.69 Published 2001 Journal J. Neuroimmunol. Section Title Doc Link 11240039 Disease Relevance 1.17 Pain Relevance 0.59
We found a highly significant increase of both IL-18 CSF and serum levels in MS patients in comparison with the control group.
Positive_regulation (increase) of IL-18 CSF
2) Confidence 0.59 Published 2001 Journal Acta Neurol. Scand. Section Abstract Doc Link 11551238 Disease Relevance 0.27 Pain Relevance 0.17
In EAN, IL-18 and caspase-1 mRNA levels in the nerve roots increased during the stage of active disease progression.
Positive_regulation (increased) of IL-18 in nerve associated with neuritis and disease progression
3) Confidence 0.50 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.41 Pain Relevance 0.70
Here we show that both the IL-18 and IL-18 receptor (IL-18R), which are induced in spinal dorsal horn, are crucial for tactile allodynia after nerve injury.
Positive_regulation (induced) of IL-18 in nerve associated with brush evoked pain, nervous system injury and spinal dorsal horn
4) Confidence 0.24 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.64 Pain Relevance 0.41
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Positive_regulation (upregulated) of IL-18 in astrocytes associated with nervous system injury and dorsal horn
5) Confidence 0.24 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.69 Pain Relevance 0.52
These effects are mediated in part by induction of downstream inflammatory cytokines and chemokines, especially IL-1beta, IL-18, and leptin.
Positive_regulation (induction) of IL-18 associated with chemokine, inflammation and cytokine
6) Confidence 0.22 Published 2010 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 20543002 Disease Relevance 0.72 Pain Relevance 0.38
Here we show that both the IL-18 and IL-18 receptor (IL-18R), which are induced in spinal dorsal horn, are crucial for tactile allodynia after nerve injury.
Positive_regulation (induced) of IL-18 in nerve associated with brush evoked pain, nervous system injury and spinal dorsal horn
7) Confidence 0.11 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.64 Pain Relevance 0.41
Elevated levels of IL-18 have been associated with an increased risk of developing type 2-diabetes [28].
Positive_regulation (levels) of IL-18 associated with diabetes mellitus
8) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 1.17 Pain Relevance 0.13
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Positive_regulation (upregulated) of IL-18 in microglia associated with nervous system injury and dorsal horn
9) Confidence 0.08 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.69 Pain Relevance 0.52
Interleukin-18 in patients with congestive heart failure: induction of atrial natriuretic peptide gene expression.
Positive_regulation (induction) of Interleukin-18 in heart associated with natriuresis and heart rate under development
10) Confidence 0.08 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Title Doc Link 11758978 Disease Relevance 0.89 Pain Relevance 0.18
Compared with the control group, IL-12 concentrations were significantly higher in both the SAP and UAP groups, especially in the UAP group, and the IL-18 concentrations tended to be higher in the UAP group.
Positive_regulation (higher) of IL-18 associated with angina
11) Confidence 0.07 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12521622 Disease Relevance 1.39 Pain Relevance 1.36
Activated white adipose tissue increases the synthesis of pro-inflammatory cytokines, such as IL-6, IL-1, IL-8, TNFalpha, IL-18, while regulatory cytokines, such as IL-10, are decreased.
Positive_regulation (increases) of IL-18 in adipose tissue associated with inflammation, obesity and cytokine
12) Confidence 0.03 Published 2010 Journal Curr Drug Targets Section Abstract Doc Link 20199391 Disease Relevance 1.80 Pain Relevance 0.78
In pancreatic cancer patients indeed increased levels of several cytokines such as IL-6, IL-18 and TNF-alpha can be found.
Positive_regulation (increased) of IL-18 associated with pancreatic cancer and cytokine
13) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976753 Disease Relevance 2.03 Pain Relevance 0.60
IL-6 levels continued to fall from days 2 to 3 (p<0.05), whereas increased levels were found for several cytokines (IL-12, IL-13, IL-18 and IL-1beta) (p<0.05).
Positive_regulation (increased) of IL-18 associated with cytokine
14) Confidence 0.01 Published 2006 Journal Acta Trop. Section Abstract Doc Link 16962547 Disease Relevance 0.49 Pain Relevance 0.72

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