INT94166

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Context Info
Confidence 0.79
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.75
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK1) mitochondrion (CDK1) protein complex assembly (CDK1)
cytoplasm (CDK1) cytosol (CDK1) mitosis (CDK1)
Anatomy Link Frequency
lamina 2
Upper 1
CDK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 212 65.68 Quite High
Inflammation 56 53.04 Quite High
methotrexate 12 38.36 Quite Low
Kinase C inhibitor 1 31.12 Quite Low
headache 1 25.00 Low Low
cytokine 34 12.36 Low Low
dexamethasone 14 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Kinase C 9 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 106 100.00 Very High Very High Very High
Viral Infection 20 98.88 Very High Very High Very High
Hematologic Neoplasms 4 95.64 Very High Very High Very High
Infection 172 94.40 High High
Papillomavirus Infection 246 94.00 High High
Hypoxia 35 91.32 High High
Apoptosis 48 80.08 Quite High
Aneuploidy 66 69.92 Quite High
Genomic Instability 28 65.76 Quite High
Rheumatoid Arthritis 206 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss in Rb function is, in most cases, a result of the phosphorylation and inactivation of Rb by the cyclin-dependent kinases (cdks), main regulators of cell cycle progression.
Phosphorylation (phosphorylation) of cdk associated with retinoblastoma
1) Confidence 0.79 Published 2001 Journal Leukemia Section Abstract Doc Link 11243375 Disease Relevance 0.93 Pain Relevance 0.03
The phosphorylation and dephosphorylation of CDC2 also play important regulatory roles in cell cycle control.
Phosphorylation (dephosphorylation) of CDC2
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.17 Pain Relevance 0.08
The phosphorylation and dephosphorylation of CDC2 also play important regulatory roles in cell cycle control.
Phosphorylation (phosphorylation) of CDC2
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.17 Pain Relevance 0.09
While the phosphorylation of NE components by CDK1 correlates with NE breakdown, and inhibition of cdk1 prevents NE breakdown [16],[17], some have argued that NE breakdown is initiated by mechanical tension induced by spindle microtubules, leading to holes in the NE [28],[29].
Phosphorylation (phosphorylation) of CDK1
4) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 0.54 Pain Relevance 0
Phosphorylation of NE components by CDK1 is critical for these events in early prophase [16]–[18].
Phosphorylation (Phosphorylation) of CDK1
5) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 1.78 Pain Relevance 0
Phosphorylation of this and other lamin A residues by cellular Cdk1 initiates the process of lamina breakdown during mitosis [75].
Phosphorylation (Phosphorylation) of Cdk1 in lamina
6) Confidence 0.41 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0 Pain Relevance 0
(B) Upper panel: autoradiograph of Cdc2 kinase activity (phosphorylation of histone H1) and immunoblot of Cdc2 kinase expression in lysates prepared from hFP-HEK and pCEP4-HEK cells that had been treated with either vehicle (V) or 1 µM PGF2?
Phosphorylation (phosphorylation) of Cdc2 in Upper
7) Confidence 0.33 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
Lower panel: quantitative analysis of three independent experiments by densitometry of Cdc2 kinase activity (histone H1 phosphorylation) normalized to Cdc2 immunoreactivity (means ± SEs).
Phosphorylation (phosphorylation) of Cdc2
8) Confidence 0.33 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.14 Pain Relevance 0
treatment of HEK cells stably expressing the human FP prostanoid receptor increases expression of cyclin B1 (A) and increases Cdc2-mediated phosphorylation of histone H1 (B).
Phosphorylation (phosphorylation) of Cdc2
9) Confidence 0.33 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
During mitosis, the nuclear lamina is disassembled after phosphorylation of lamin A/C by Cdk1 [73].
Phosphorylation (phosphorylation) of Cdk1 in lamina
10) Confidence 0.31 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.50 Pain Relevance 0
When treated with JAKinase inhibitors, STAT3 phosphorylation and associated proliferation factors involving cell growth and CDK1, CDK2, Rex1, Nanog, and RUNX3 expression was decreased profoundly (Figure 3A and 3B, 3C).
Phosphorylation (phosphorylation) of CDK1
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.54 Pain Relevance 0

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