INT94176

Context Info Confidence 0.11 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.09 Pain Relevance 0.11

small molecule metabolic process (NEU1) hydrolase activity, acting on glycosyl bonds (NEU1) cytoplasmic membrane-bounded vesicle (NEU1) plasma membrane (NEU1) lysosome (NEU1)

Anatomy Link Frequency brain 1 NEU1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 73.40 Central nervous system 1 67.44

Disease Link Frequency Relevance Heat Mucopolysaccharidoses 9 97.76 Lysosome Storage Disease 3 75.00 Gangliosidoses 1 63.24 Intellectual Impairment 1 59.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These changes may be, in part, due to the reduction of sialidase and UDP-N-acetylgalactosamine:GM3 N-acetylgalactosaminyltransferase (GalNAc-T) activities in MPS IIID caprine brain.

Negative_regulation (reduction) of sialidase in brain associated with mucopolysaccharidoses

1) Confidence 0.11 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11243730 Disease Relevance 1.09 Pain Relevance 0.11

General Comments

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