INT94199

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Context Info
Confidence 0.07
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 8.31
Pain Relevance 10.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRGX)
Anatomy Link Frequency
neuron 4
spinal cord 1
peripheral nerve 1
DRG 1
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 155 100.00 Very High Very High Very High
Nav1.7 129 100.00 Very High Very High Very High
Paroxysmal extreme pain disorder 110 100.00 Very High Very High Very High
Spinal cord 14 99.84 Very High Very High Very High
hyperexcitability 34 99.68 Very High Very High Very High
opioid receptor 6 99.60 Very High Very High Very High
Inflammation 11 99.44 Very High Very High Very High
Morphine 9 98.24 Very High Very High Very High
Brush evoked pain 6 98.00 Very High Very High Very High
Peripheral nerve injury 6 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 159 100.00 Very High Very High Very High
Somatoform Disorder 112 100.00 Very High Very High Very High
Nociception 27 100.00 Very High Very High Very High
Nerve Compression Syndromes 31 99.84 Very High Very High Very High
Injury 40 99.68 Very High Very High Very High
INFLAMMATION 11 99.44 Very High Very High Very High
Nervous System Injury 20 98.96 Very High Very High Very High
Neuropathic Pain 55 98.00 Very High Very High Very High
Multiple Trauma 1 94.60 High High
Pain 86 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we directly tested the effect of ranolazine on DRG neuron firing.
Regulation (effect) of DRG in neuron associated with dorsal root ganglion
1) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.42 Pain Relevance 1.19
MOR mRNA levels in the DRG were not affected 7 days after inflammation, whereas chronic morphine administration induced a discrete increase (p < 0.05).
Neg (not) Regulation (affected) of DRG in DRG associated with inflammation, opioid receptor and morphine
2) Confidence 0.06 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17468301 Disease Relevance 0.57 Pain Relevance 1.79
Previous studies have not examined the effect of PEPD mutations on DRG neuron excitability [19].
Spec (examined) Regulation (effect) of DRG neuron in neuron associated with dorsal root ganglion and paroxysmal extreme pain disorder
3) Confidence 0.05 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.49 Pain Relevance 0.46
We show that these two mutations, both within the DIII/S4-S5 linker of the channel, have differential effects on activation and inactivation, and demonstrate that both increase the excitability of DRG neurons.


Regulation (excitability) of DRG in neurons associated with dorsal root ganglion
4) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 1.50 Pain Relevance 0.94
Epistasis studies revealed several putative effectors of known DHE transcription factors such as Drg11, Tlx3(Rnx), and Lmx1b.
Regulation (effectors) of Drg11
5) Confidence 0.04 Published 2006 Journal Dev. Biol. Section Abstract Doc Link 16516881 Disease Relevance 0.06 Pain Relevance 0.39
We used voltage- and current-clamp recordings to evaluate the hypothesis that ranolazine may be effective in regulating Nav1.7-induced DRG neuron hyperexcitability.


Regulation (regulating) of DRG in neuron associated with hyperexcitability and nav1.7
6) Confidence 0.04 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2898769 Disease Relevance 0.76 Pain Relevance 1.74
In the present study, we detected ipsilaterally decreased DRG NaV1.8 immunoreactivity (Fig. 3), but NaV1.8 mRNA levels in the DRG were not affected by SNE injury (Figs. 4 &5).
Neg (not) Regulation (affected) of DRG associated with dorsal root ganglion, injury and nerve compression syndromes
7) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 2.03 Pain Relevance 0.84
We assessed the temporal regulation of several molecular markers of nociceptive and regenerative processes in DRG or spinal cord following intraplantar injection of RTX.
Regulation (regulation) of DRG in spinal cord associated with nociception and spinal cord
8) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.46 Pain Relevance 0.71
RNase protection experiments indicated that the DRG alpha(2)delta regulation was at the mRNA level.
Regulation (regulation) of DRG alpha
9) Confidence 0.00 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11245671 Disease Relevance 1.08 Pain Relevance 1.35
These data suggest that DRG alpha(2)delta regulation may play an unique role in neuroplasticity after peripheral nerve injury that may contribute to allodynia development.
Regulation (regulation) of DRG alpha in peripheral nerve associated with nervous system injury, allodynia and peripheral nerve injury
10) Confidence 0.00 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11245671 Disease Relevance 0.95 Pain Relevance 0.98

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