INT94270

Context Info Confidence 0.17 First Reported 2001 Last Reported 2001 Negated 2 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.67 Pain Relevance 1.60

cytoplasm (Pomc, Crh) extracellular space (Pomc, Crh) extracellular region (Pomc, Crh) response to stress (Crh) cell-cell signaling (Pomc) generation of precursor metabolites and energy (Pomc)

Anatomy Link Frequency nucleus 4 Pomc (Rattus norvegicus) Crh (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 12 99.92 Opioid 4 95.20 Intracerebroventricular 4 91.76 opioid receptor 4 67.24 Central nervous system 2 64.00 Arthritis 6 59.28 Inflammation 2 29.28

Disease Link Frequency Relevance Heat Stress 12 91.84 Arthritis 6 59.28 INFLAMMATION 2 29.28

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Corticotrophin-releasing factor (CRF) mRNA and arginine vasopressin (AVP) mRNA in the paraventricular nucleus (PVN) and POMC mRNA in the anterior pituitary were found to be unaffected by either morphine or endomorphins.

POMC mRNA Neg (unaffected) Regulation (unaffected) of Transcription (mRNA) of CRF in nucleus associated with morphine

1) Confidence 0.17 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11250660 Disease Relevance 0.34 Pain Relevance 0.79

Corticotrophin-releasing factor (CRF) mRNA and arginine vasopressin (AVP) mRNA in the paraventricular nucleus (PVN) and POMC mRNA in the anterior pituitary were found to be unaffected by either morphine or endomorphins.

POMC mRNA Neg (unaffected) Regulation (unaffected) of Transcription (mRNA) of Corticotrophin-releasing factor in nucleus associated with morphine

2) Confidence 0.17 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11250660 Disease Relevance 0.34 Pain Relevance 0.80

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